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Plasma amylase activity as a biochemical indicator of radiation injury to salivary glands

Abstract

Irradiation of the salivary glands produces a rapid increase of salivary amylase in serum, released by the highly radiation sensitive serous cells of the glands. Serial assays of salivary amylase in serum were performed in patients treated by radiation to the upper neck region. The changes observed were compared with the amount of salivary gland mass irradiated and with the dose fractionation modality used. The irradiated volume included either the entire salivary gland mass or less than 50 per cent of the gland. Two fractionation modalities were used: a conventional fractionation of 2 Gy per day, 5 times a week, or a multiple daily fractionation of 2 Gy, 3 times a day in two series of 4 days with a 4-day interval. Both parameters (salivary gland mass irradiated and fractionation modality used) significantly influenced the shape of the amylase curve in the serum. Serum amylase may therefore be considered a reliable biologic indicator of early injury to the salivary glands.
Authors:
Becciolini, A; Giannardi, G; Cionini, L; Porciani, S; Fallai, C; Pirtoli, L [1] 
  1. Florence Univ. (Italy). Ist. di Radiologia
Publication Date:
Jan 01, 1984
Product Type:
Journal Article
Reference Number:
AIX-16-001998; EDB-85-029892
Resource Relation:
Journal Name: Acta Radiol.: Oncol.; (Sweden); Journal Volume: 23:1; Other Information: Supersedes Acta Radiol., Oncol., Radiat. Ther., Phys. Biol
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; AMYLASE; BIOLOGICAL RADIATION EFFECTS; SALIVARY GLANDS; RADIATION INJURIES; BIOLOGICAL INDICATORS; BLOOD SERUM; CATALYSIS; CORRELATIONS; DOSE-RESPONSE RELATIONSHIPS; FRACTIONATED IRRADIATION; METABOLISM; NECK; NEOPLASMS; PATIENTS; RADIATION DOSES; RADIOTHERAPY; STATISTICAL DATA; BIOLOGICAL EFFECTS; BODY; BODY AREAS; DATA; DISEASES; DOSES; ENZYMES; GLANDS; GLYCOSYL HYDROLASES; HYDROLASES; INFORMATION; INJURIES; IRRADIATION; MEDICINE; NUCLEAR MEDICINE; NUMERICAL DATA; O-GLYCOSYL HYDROLASES; ORGANS; RADIATION EFFECTS; RADIOLOGY; THERAPY; 560115* - Radiation Effects on Biochemicals- In Man- (-1987); 560151 - Radiation Effects on Animals- Man
OSTI ID:
6209551
Country of Origin:
Sweden
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: AROBD
Submitting Site:
HEDB
Size:
Pages: 9-14
Announcement Date:

Citation Formats

Becciolini, A, Giannardi, G, Cionini, L, Porciani, S, Fallai, C, and Pirtoli, L. Plasma amylase activity as a biochemical indicator of radiation injury to salivary glands. Sweden: N. p., 1984. Web. doi:10.3109/02841868409135978.
Becciolini, A, Giannardi, G, Cionini, L, Porciani, S, Fallai, C, & Pirtoli, L. Plasma amylase activity as a biochemical indicator of radiation injury to salivary glands. Sweden. doi:10.3109/02841868409135978.
Becciolini, A, Giannardi, G, Cionini, L, Porciani, S, Fallai, C, and Pirtoli, L. 1984. "Plasma amylase activity as a biochemical indicator of radiation injury to salivary glands." Sweden. doi:10.3109/02841868409135978. https://www.osti.gov/servlets/purl/10.3109/02841868409135978.
@misc{etde_6209551,
title = {Plasma amylase activity as a biochemical indicator of radiation injury to salivary glands}
author = {Becciolini, A, Giannardi, G, Cionini, L, Porciani, S, Fallai, C, and Pirtoli, L}
abstractNote = {Irradiation of the salivary glands produces a rapid increase of salivary amylase in serum, released by the highly radiation sensitive serous cells of the glands. Serial assays of salivary amylase in serum were performed in patients treated by radiation to the upper neck region. The changes observed were compared with the amount of salivary gland mass irradiated and with the dose fractionation modality used. The irradiated volume included either the entire salivary gland mass or less than 50 per cent of the gland. Two fractionation modalities were used: a conventional fractionation of 2 Gy per day, 5 times a week, or a multiple daily fractionation of 2 Gy, 3 times a day in two series of 4 days with a 4-day interval. Both parameters (salivary gland mass irradiated and fractionation modality used) significantly influenced the shape of the amylase curve in the serum. Serum amylase may therefore be considered a reliable biologic indicator of early injury to the salivary glands.}
doi = {10.3109/02841868409135978}
journal = {Acta Radiol.: Oncol.; (Sweden)}
volume = {23:1}
journal type = {AC}
place = {Sweden}
year = {1984}
month = {Jan}
}