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Effect of tamoxifen pre-treatment on the retention of tritiated oestradiol and 5. cap alpha. -dihydrotestosterone and on glucose metabolism in human breast carcinomas

Journal Article:

Abstract

The effect of pre-treatment with tamoxifen on glucose metabolism and retention of injected oestradiol-17B and 5..cap alpha..-dihydrotestosterone by human breast carcinomas were studied in patients undergoing mastectomy. The following effects were observed: the pretreatment reduced retention of oestradiol-17B whereas a small but statistically significant rise in 5..cap alpha..-dihydrotestosterone accumulation was observed. There was an increase in both phosphofructokinase (PFK) and glucose-6-phosphate dehydrogenase (G6PDH) activities in tumours from treated patients whereas ..cap alpha..-glycerolphosphate dehydrogenase (..cap alpha..-GPDH) activity was significantly reduced in the same tumours. The significance of these findings is discussed and it is argued that these changes in carbohydrate metabolism may not be due to the blocking of hormone receptors.
Authors:
Deshpande, N; Mitchell, I; [1]  Hughes, D
  1. Imperial Cancer Research Fund, London (UK). Labs.
Publication Date:
May 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-10-420948; EDB-79-051726
Resource Relation:
Journal Name: Eur. J. Cancer; (United Kingdom); Journal Volume: 14:5
Subject:
59 BASIC BIOLOGICAL SCIENCES; ANTINEOPLASTIC DRUGS; RESPONSE MODIFYING FACTORS; GLUCOSE; METABOLISM; MAMMARY GLANDS; CARCINOMAS; BIOLOGICAL LOCALIZATION; CATALYSIS; DEHYDROGENASES; ESTRADIOL; PATIENTS; PHOSPHOTRANSFERASES; STEROID HORMONES; TESTOSTERONE; TRITIUM COMPOUNDS; UPTAKE; WOMEN; ALDEHYDES; ANDROGENS; ANDROSTANES; ANIMALS; BODY; CARBOHYDRATES; DISEASES; DRUGS; ENZYMES; ESTRANES; ESTROGENS; FEMALES; GLANDS; HEXOSES; HORMONES; HYDROXY COMPOUNDS; KETONES; LABELLED COMPOUNDS; MAMMALS; MAN; MONOSACCHARIDES; NEOPLASMS; ORGANIC COMPOUNDS; ORGANS; OXIDOREDUCTASES; PRIMATES; SACCHARIDES; STEROIDS; TRANSFERASES; VERTEBRATES; 550901* - Pathology- Tracer Techniques
OSTI ID:
6204079
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EJCAA
Submitting Site:
INIS
Size:
Pages: 473-477
Announcement Date:

Journal Article:

Citation Formats

Deshpande, N, Mitchell, I, and Hughes, D. Effect of tamoxifen pre-treatment on the retention of tritiated oestradiol and 5. cap alpha. -dihydrotestosterone and on glucose metabolism in human breast carcinomas. United Kingdom: N. p., 1978. Web.
Deshpande, N, Mitchell, I, & Hughes, D. Effect of tamoxifen pre-treatment on the retention of tritiated oestradiol and 5. cap alpha. -dihydrotestosterone and on glucose metabolism in human breast carcinomas. United Kingdom.
Deshpande, N, Mitchell, I, and Hughes, D. 1978. "Effect of tamoxifen pre-treatment on the retention of tritiated oestradiol and 5. cap alpha. -dihydrotestosterone and on glucose metabolism in human breast carcinomas." United Kingdom.
@misc{etde_6204079,
title = {Effect of tamoxifen pre-treatment on the retention of tritiated oestradiol and 5. cap alpha. -dihydrotestosterone and on glucose metabolism in human breast carcinomas}
author = {Deshpande, N, Mitchell, I, and Hughes, D}
abstractNote = {The effect of pre-treatment with tamoxifen on glucose metabolism and retention of injected oestradiol-17B and 5..cap alpha..-dihydrotestosterone by human breast carcinomas were studied in patients undergoing mastectomy. The following effects were observed: the pretreatment reduced retention of oestradiol-17B whereas a small but statistically significant rise in 5..cap alpha..-dihydrotestosterone accumulation was observed. There was an increase in both phosphofructokinase (PFK) and glucose-6-phosphate dehydrogenase (G6PDH) activities in tumours from treated patients whereas ..cap alpha..-glycerolphosphate dehydrogenase (..cap alpha..-GPDH) activity was significantly reduced in the same tumours. The significance of these findings is discussed and it is argued that these changes in carbohydrate metabolism may not be due to the blocking of hormone receptors.}
journal = {Eur. J. Cancer; (United Kingdom)}
volume = {14:5}
journal type = {AC}
place = {United Kingdom}
year = {1978}
month = {May}
}