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Repair of the double-strand breaks produced by /sup 125/I disintegrations in the DNA of micrococcus radiodurans

Abstract

Wild-type M. radiodurans and two radiosensitive mutants were used to study the lethal effects of /sup 125/I disintegrations in their DNA. The relative sensitivities of these three strains to inactivation by ..gamma..-radiation were reflected in their relative sensitivities to inactivation by /sup 125/I decay. The number of double-strand (ds) breaks in the DNA appeared to be similar at levels of ..gamma..-radiation and of /sup 125/I decay that reduced survival to 10%. All three strains of M. radiodurans rapidly repaired ds breaks produced in their DNA by either ..gamma..-radiation or /sup 125/I disintegrations. If one ds break per cell is a lethal event (Krisch. et al., 1975), cells of the three strains tested would die when they had left unrepaired one ds break out of an initial 45, 600 or 1800 ds breaks per single cell.
Authors:
Myers, D K [1] 
  1. Atomic Energy of Canada Ltd., Chalk River, Ontario. Chalk River Nuclear Labs.
Publication Date:
Jan 01, 1978
Product Type:
Conference
Reference Number:
AIX-10-420976; EDB-79-051753
Resource Relation:
Journal Name: Curr. Top. Radiat. Res.; (Netherlands); Journal Volume: 12:1; Conference: International conference on molecular- and microdistribution of radioisotopes and biological consequences, Juelich, Germany, F.R., 2 - 4 Oct 1975
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; IODINE 125; BIOLOGICAL RADIATION EFFECTS; STRAND BREAKS; BIOLOGICAL REPAIR; DNA; ELECTRON CAPTURE DECAY; LETHAL MUTATIONS; MICROCOCCUS RADIODURANS; RADIOSENSITIVITY; BACTERIA; BETA DECAY; BETA DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; DAYS LIVING RADIOISOTOPES; DECAY; ELECTRON CAPTURE RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MICROCOCCUS; MICROORGANISMS; MUTATIONS; NUCLEI; NUCLEIC ACIDS; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; RADIATION EFFECTS; RADIOISOTOPES; RECOVERY; REPAIR; 560111* - Radiation Effects on Biochemicals- In Vitro- (-1987)
OSTI ID:
6203871
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CTRRA
Submitting Site:
INIS
Size:
Pages: 369-388
Announcement Date:

Citation Formats

Myers, D K. Repair of the double-strand breaks produced by /sup 125/I disintegrations in the DNA of micrococcus radiodurans. Netherlands: N. p., 1978. Web.
Myers, D K. Repair of the double-strand breaks produced by /sup 125/I disintegrations in the DNA of micrococcus radiodurans. Netherlands.
Myers, D K. 1978. "Repair of the double-strand breaks produced by /sup 125/I disintegrations in the DNA of micrococcus radiodurans." Netherlands.
@misc{etde_6203871,
title = {Repair of the double-strand breaks produced by /sup 125/I disintegrations in the DNA of micrococcus radiodurans}
author = {Myers, D K}
abstractNote = {Wild-type M. radiodurans and two radiosensitive mutants were used to study the lethal effects of /sup 125/I disintegrations in their DNA. The relative sensitivities of these three strains to inactivation by ..gamma..-radiation were reflected in their relative sensitivities to inactivation by /sup 125/I decay. The number of double-strand (ds) breaks in the DNA appeared to be similar at levels of ..gamma..-radiation and of /sup 125/I decay that reduced survival to 10%. All three strains of M. radiodurans rapidly repaired ds breaks produced in their DNA by either ..gamma..-radiation or /sup 125/I disintegrations. If one ds break per cell is a lethal event (Krisch. et al., 1975), cells of the three strains tested would die when they had left unrepaired one ds break out of an initial 45, 600 or 1800 ds breaks per single cell.}
journal = {Curr. Top. Radiat. Res.; (Netherlands)}
volume = {12:1}
place = {Netherlands}
year = {1978}
month = {Jan}
}