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Protective efficacy of combined administration of lipopolysaccharide of E. coli and chemical radioprotectors under conditions of prolonged irradiation

Journal Article:

Abstract

We investigated the protective effectiveness of the lipopolysaccharide of E. coli (LPS) in a combination with a mixture of chemical radioprotectors in female mice of the strain H at various radiation dose rates. LPS in a dose of 0.08 mg per kg of body mass was administered 1, 3, or 24 hours prior to irradiation, the radioprotective mixture (cystamine 90 mgxkg/sup -1/+5-methoxytryptamine 15 mgxkg/sup -1/) was administered 10 minutes before irradiation. Dose rates of 612 mGyxmin/sup -1/ (irradiation time 10 to 15 minutes), 38 mGyxmin/sup -1/ (3 to 4 hours), and 8.2 mGyxmin/sup -1/ (27 to 29 hours) were used. The results showed that isolated administrations of LPS or of the radioprotective mixture increased the resistance of the mice against prolonged irradiation; the combined administration even enhanced the efficacy of the radioprotective action. However, this efficacy depended on the magnitude of the dose rate. At dose rates higher than 38 mGyxmin/sup -1/ the effectiveness of the chemical protection prevailed, whereas at lower dose rates the biological and especially the combined protection became effective. We demonstrate a slight pyrogenic effect of LPS by measuring oxygen consumption and changes in some parameters of the hematopoiesis.
Publication Date:
Jul 01, 1984
Product Type:
Journal Article
Reference Number:
FRG-84-13653; EDB-85-015649
Resource Relation:
Journal Name: Strahlentherapie; (Germany, Federal Republic of); Journal Volume: 160:7
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CYSTAMINE; RADIOSENSITIVITY EFFECTS; LIPOPOLYSACCHARIDES; MICE; BIOLOGICAL RADIATION EFFECTS; TRYPTAMINES; BONE MARROW; CHRONIC IRRADIATION; DOSE-RESPONSE RELATIONSHIPS; ENDOTOXINS; ESCHERICHIA COLI; IRRADIATION PROCEDURES; LETHAL RADIATION DOSE; RADIOSENSITIVITY; SPLEEN COLONY FORMATION; SURVIVAL CURVES; AMINES; ANIMAL TISSUES; ANIMALS; ANTIGENS; AROMATICS; AZAARENES; AZOLES; BACTERIA; BIOLOGICAL EFFECTS; BODY; CARBOHYDRATES; CHRONIC EXPOSURE; COLONY FORMATION; DOSES; DRUGS; HEMATOPOIETIC SYSTEM; HETEROCYCLIC COMPOUNDS; INDOLES; IRRADIATION; LETHAL DOSES; LIPIDS; MAMMALS; MATERIALS; MICROORGANISMS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; POLYSACCHARIDES; PYRROLES; RADIATION DOSES; RADIATION EFFECTS; RADIOPROTECTIVE SUBSTANCES; RODENTS; SACCHARIDES; TISSUES; TOXIC MATERIALS; TOXINS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
6201239
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: STRAA
Submitting Site:
HEDB
Size:
Pages: 439-444
Announcement Date:
Nov 01, 1984

Journal Article:

Citation Formats

Misustova, J, Hosek, B, Sikulova, J, Kautska, J, and Fjodorov, B A. Protective efficacy of combined administration of lipopolysaccharide of E. coli and chemical radioprotectors under conditions of prolonged irradiation. Germany: N. p., 1984. Web.
Misustova, J, Hosek, B, Sikulova, J, Kautska, J, & Fjodorov, B A. Protective efficacy of combined administration of lipopolysaccharide of E. coli and chemical radioprotectors under conditions of prolonged irradiation. Germany.
Misustova, J, Hosek, B, Sikulova, J, Kautska, J, and Fjodorov, B A. 1984. "Protective efficacy of combined administration of lipopolysaccharide of E. coli and chemical radioprotectors under conditions of prolonged irradiation." Germany.
@misc{etde_6201239,
title = {Protective efficacy of combined administration of lipopolysaccharide of E. coli and chemical radioprotectors under conditions of prolonged irradiation}
author = {Misustova, J, Hosek, B, Sikulova, J, Kautska, J, and Fjodorov, B A}
abstractNote = {We investigated the protective effectiveness of the lipopolysaccharide of E. coli (LPS) in a combination with a mixture of chemical radioprotectors in female mice of the strain H at various radiation dose rates. LPS in a dose of 0.08 mg per kg of body mass was administered 1, 3, or 24 hours prior to irradiation, the radioprotective mixture (cystamine 90 mgxkg/sup -1/+5-methoxytryptamine 15 mgxkg/sup -1/) was administered 10 minutes before irradiation. Dose rates of 612 mGyxmin/sup -1/ (irradiation time 10 to 15 minutes), 38 mGyxmin/sup -1/ (3 to 4 hours), and 8.2 mGyxmin/sup -1/ (27 to 29 hours) were used. The results showed that isolated administrations of LPS or of the radioprotective mixture increased the resistance of the mice against prolonged irradiation; the combined administration even enhanced the efficacy of the radioprotective action. However, this efficacy depended on the magnitude of the dose rate. At dose rates higher than 38 mGyxmin/sup -1/ the effectiveness of the chemical protection prevailed, whereas at lower dose rates the biological and especially the combined protection became effective. We demonstrate a slight pyrogenic effect of LPS by measuring oxygen consumption and changes in some parameters of the hematopoiesis.}
journal = {Strahlentherapie; (Germany, Federal Republic of)}
volume = {160:7}
journal type = {AC}
place = {Germany}
year = {1984}
month = {Jul}
}