Abstract
We investigated the protective effectiveness of the lipopolysaccharide of E. coli (LPS) in a combination with a mixture of chemical radioprotectors in female mice of the strain H at various radiation dose rates. LPS in a dose of 0.08 mg per kg of body mass was administered 1, 3, or 24 hours prior to irradiation, the radioprotective mixture (cystamine 90 mgxkg/sup -1/+5-methoxytryptamine 15 mgxkg/sup -1/) was administered 10 minutes before irradiation. Dose rates of 612 mGyxmin/sup -1/ (irradiation time 10 to 15 minutes), 38 mGyxmin/sup -1/ (3 to 4 hours), and 8.2 mGyxmin/sup -1/ (27 to 29 hours) were used. The results showed that isolated administrations of LPS or of the radioprotective mixture increased the resistance of the mice against prolonged irradiation; the combined administration even enhanced the efficacy of the radioprotective action. However, this efficacy depended on the magnitude of the dose rate. At dose rates higher than 38 mGyxmin/sup -1/ the effectiveness of the chemical protection prevailed, whereas at lower dose rates the biological and especially the combined protection became effective. We demonstrate a slight pyrogenic effect of LPS by measuring oxygen consumption and changes in some parameters of the hematopoiesis.
Citation Formats
Misustova, J, Hosek, B, Sikulova, J, Kautska, J, and Fjodorov, B A.
Protective efficacy of combined administration of lipopolysaccharide of E. coli and chemical radioprotectors under conditions of prolonged irradiation.
Germany: N. p.,
1984.
Web.
Misustova, J, Hosek, B, Sikulova, J, Kautska, J, & Fjodorov, B A.
Protective efficacy of combined administration of lipopolysaccharide of E. coli and chemical radioprotectors under conditions of prolonged irradiation.
Germany.
Misustova, J, Hosek, B, Sikulova, J, Kautska, J, and Fjodorov, B A.
1984.
"Protective efficacy of combined administration of lipopolysaccharide of E. coli and chemical radioprotectors under conditions of prolonged irradiation."
Germany.
@misc{etde_6201239,
title = {Protective efficacy of combined administration of lipopolysaccharide of E. coli and chemical radioprotectors under conditions of prolonged irradiation}
author = {Misustova, J, Hosek, B, Sikulova, J, Kautska, J, and Fjodorov, B A}
abstractNote = {We investigated the protective effectiveness of the lipopolysaccharide of E. coli (LPS) in a combination with a mixture of chemical radioprotectors in female mice of the strain H at various radiation dose rates. LPS in a dose of 0.08 mg per kg of body mass was administered 1, 3, or 24 hours prior to irradiation, the radioprotective mixture (cystamine 90 mgxkg/sup -1/+5-methoxytryptamine 15 mgxkg/sup -1/) was administered 10 minutes before irradiation. Dose rates of 612 mGyxmin/sup -1/ (irradiation time 10 to 15 minutes), 38 mGyxmin/sup -1/ (3 to 4 hours), and 8.2 mGyxmin/sup -1/ (27 to 29 hours) were used. The results showed that isolated administrations of LPS or of the radioprotective mixture increased the resistance of the mice against prolonged irradiation; the combined administration even enhanced the efficacy of the radioprotective action. However, this efficacy depended on the magnitude of the dose rate. At dose rates higher than 38 mGyxmin/sup -1/ the effectiveness of the chemical protection prevailed, whereas at lower dose rates the biological and especially the combined protection became effective. We demonstrate a slight pyrogenic effect of LPS by measuring oxygen consumption and changes in some parameters of the hematopoiesis.}
journal = []
volume = {160:7}
journal type = {AC}
place = {Germany}
year = {1984}
month = {Jul}
}
title = {Protective efficacy of combined administration of lipopolysaccharide of E. coli and chemical radioprotectors under conditions of prolonged irradiation}
author = {Misustova, J, Hosek, B, Sikulova, J, Kautska, J, and Fjodorov, B A}
abstractNote = {We investigated the protective effectiveness of the lipopolysaccharide of E. coli (LPS) in a combination with a mixture of chemical radioprotectors in female mice of the strain H at various radiation dose rates. LPS in a dose of 0.08 mg per kg of body mass was administered 1, 3, or 24 hours prior to irradiation, the radioprotective mixture (cystamine 90 mgxkg/sup -1/+5-methoxytryptamine 15 mgxkg/sup -1/) was administered 10 minutes before irradiation. Dose rates of 612 mGyxmin/sup -1/ (irradiation time 10 to 15 minutes), 38 mGyxmin/sup -1/ (3 to 4 hours), and 8.2 mGyxmin/sup -1/ (27 to 29 hours) were used. The results showed that isolated administrations of LPS or of the radioprotective mixture increased the resistance of the mice against prolonged irradiation; the combined administration even enhanced the efficacy of the radioprotective action. However, this efficacy depended on the magnitude of the dose rate. At dose rates higher than 38 mGyxmin/sup -1/ the effectiveness of the chemical protection prevailed, whereas at lower dose rates the biological and especially the combined protection became effective. We demonstrate a slight pyrogenic effect of LPS by measuring oxygen consumption and changes in some parameters of the hematopoiesis.}
journal = []
volume = {160:7}
journal type = {AC}
place = {Germany}
year = {1984}
month = {Jul}
}