Abstract
Glycogen metabolism in mammary epithelial cells was investigated (i) by studying the conversion of glucose into glycogen and other cellular products in these cells from virgin, pregnant and lactating mice and (ii) by assaying the enzymes directly involved with glycogen metabolism. We find that: (1) mammary epithelial cells synthesized glycogen at rates up to over 60% that of the whole gland; (2) the rate of this synthesis was modulated greatly during the reproductive cycle, reaching a peak in late pregnancy and decreasing rapidly at parturition, when abundant synthesis of lactose was initiated. We propose that glycogen bynthesis restricts lactose synthesis during late pregnancy by competing successfully for the shared UDP-glucose pool. The physiological advantage of glycogen accumulation during late pregnancy is discussed.
Citation Formats
Emerman, J T, Bartley, J C, and Bissell, M J.
Interrelationship of glyocen metabolism and lactose synthesis in mammary epithelial cells of mice.
United Kingdom: N. p.,
1980.
Web.
Emerman, J T, Bartley, J C, & Bissell, M J.
Interrelationship of glyocen metabolism and lactose synthesis in mammary epithelial cells of mice.
United Kingdom.
Emerman, J T, Bartley, J C, and Bissell, M J.
1980.
"Interrelationship of glyocen metabolism and lactose synthesis in mammary epithelial cells of mice."
United Kingdom.
@misc{etde_6197432,
title = {Interrelationship of glyocen metabolism and lactose synthesis in mammary epithelial cells of mice}
author = {Emerman, J T, Bartley, J C, and Bissell, M J}
abstractNote = {Glycogen metabolism in mammary epithelial cells was investigated (i) by studying the conversion of glucose into glycogen and other cellular products in these cells from virgin, pregnant and lactating mice and (ii) by assaying the enzymes directly involved with glycogen metabolism. We find that: (1) mammary epithelial cells synthesized glycogen at rates up to over 60% that of the whole gland; (2) the rate of this synthesis was modulated greatly during the reproductive cycle, reaching a peak in late pregnancy and decreasing rapidly at parturition, when abundant synthesis of lactose was initiated. We propose that glycogen bynthesis restricts lactose synthesis during late pregnancy by competing successfully for the shared UDP-glucose pool. The physiological advantage of glycogen accumulation during late pregnancy is discussed.}
journal = []
volume = {192}
journal type = {AC}
place = {United Kingdom}
year = {1980}
month = {Jan}
}
title = {Interrelationship of glyocen metabolism and lactose synthesis in mammary epithelial cells of mice}
author = {Emerman, J T, Bartley, J C, and Bissell, M J}
abstractNote = {Glycogen metabolism in mammary epithelial cells was investigated (i) by studying the conversion of glucose into glycogen and other cellular products in these cells from virgin, pregnant and lactating mice and (ii) by assaying the enzymes directly involved with glycogen metabolism. We find that: (1) mammary epithelial cells synthesized glycogen at rates up to over 60% that of the whole gland; (2) the rate of this synthesis was modulated greatly during the reproductive cycle, reaching a peak in late pregnancy and decreasing rapidly at parturition, when abundant synthesis of lactose was initiated. We propose that glycogen bynthesis restricts lactose synthesis during late pregnancy by competing successfully for the shared UDP-glucose pool. The physiological advantage of glycogen accumulation during late pregnancy is discussed.}
journal = []
volume = {192}
journal type = {AC}
place = {United Kingdom}
year = {1980}
month = {Jan}
}