Abstract
Whole body neonatal irradiation (450 rads) of Swiss-Webster mice resulted in progressive intercapillary glomerulosclerosis (IGS). Neonatal thymectomy potentiated the effect of irradiation. Removal of the spleen at 18 days markedly reduced the effect of irradiation on the kidney when combined with thymectomy at birth. In the presence of an intact thymus, splenectomy had no effect on the course of radiation induced IGS. Germinal center formation and plasma cell infiltration were observed in the thymus of splenectomized-irradiated mice. The possible role of immunity in the pathogenesis of late effects of x-ray on the kidney is considered in the light of these findings.
Citation Formats
Guttman, P H.
Effect of thymectomy and splenectomy on the course of x-ray induced progressive intercapillary glomerulosclerosis in the mouse kidney.
Switzerland: N. p.,
1967.
Web.
Guttman, P H.
Effect of thymectomy and splenectomy on the course of x-ray induced progressive intercapillary glomerulosclerosis in the mouse kidney.
Switzerland.
Guttman, P H.
1967.
"Effect of thymectomy and splenectomy on the course of x-ray induced progressive intercapillary glomerulosclerosis in the mouse kidney."
Switzerland.
@misc{etde_6195358,
title = {Effect of thymectomy and splenectomy on the course of x-ray induced progressive intercapillary glomerulosclerosis in the mouse kidney}
author = {Guttman, P H}
abstractNote = {Whole body neonatal irradiation (450 rads) of Swiss-Webster mice resulted in progressive intercapillary glomerulosclerosis (IGS). Neonatal thymectomy potentiated the effect of irradiation. Removal of the spleen at 18 days markedly reduced the effect of irradiation on the kidney when combined with thymectomy at birth. In the presence of an intact thymus, splenectomy had no effect on the course of radiation induced IGS. Germinal center formation and plasma cell infiltration were observed in the thymus of splenectomized-irradiated mice. The possible role of immunity in the pathogenesis of late effects of x-ray on the kidney is considered in the light of these findings.}
journal = []
volume = {31}
journal type = {AC}
place = {Switzerland}
year = {1967}
month = {Jan}
}
title = {Effect of thymectomy and splenectomy on the course of x-ray induced progressive intercapillary glomerulosclerosis in the mouse kidney}
author = {Guttman, P H}
abstractNote = {Whole body neonatal irradiation (450 rads) of Swiss-Webster mice resulted in progressive intercapillary glomerulosclerosis (IGS). Neonatal thymectomy potentiated the effect of irradiation. Removal of the spleen at 18 days markedly reduced the effect of irradiation on the kidney when combined with thymectomy at birth. In the presence of an intact thymus, splenectomy had no effect on the course of radiation induced IGS. Germinal center formation and plasma cell infiltration were observed in the thymus of splenectomized-irradiated mice. The possible role of immunity in the pathogenesis of late effects of x-ray on the kidney is considered in the light of these findings.}
journal = []
volume = {31}
journal type = {AC}
place = {Switzerland}
year = {1967}
month = {Jan}
}