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Activation of radiosensitizers by hypoxic cells

Journal Article:

Abstract

Hypoxic cells metabolize nitroheterocyclic compounds to produce toxic intermediates capable of affecting the survival of neighboring oxygenated cells. Mutagenesis experiments with E. coli WP-2 343 (deficient in nitro-reductase) indicated that reduction of nitroheterocyclics outside bacteria causes killing and mutations within bacteria, presumably due to the transfer of the 'active' specie(s). Using animal tissue slices to reduce nitrofurans, cultured L-929 cells incubated under aerobic conditions were far more sensitive to the toxic and DNA damaging effects of these drugs. Transfer of the active species also occurs in a tissue-like environment in multicell spheroids where the presence of a hypoxic central core served to convert the nitroheterocyclics to intermediates which also damaged the neighbouring oxygenated cells.
Authors:
Olive, P L; Durand, R E [1] 
  1. Wisconsin Clinical Cancer Center, Madison (USA). Dept. of Human Oncology
Publication Date:
Jun 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-10-448509; EDB-79-096266
Resource Relation:
Journal Name: Br. J. Cancer; (United Kingdom); Journal Volume: 37
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANIMAL CELLS; RADIOSENSITIZERS; FURANS; NITRO COMPOUNDS; TOXICITY; ANOXIA; CELL CULTURES; CELL KILLING; DNA; ESCHERICHIA COLI; METABOLISM; MUTAGENESIS; OXYGEN; REDUCTION; TISSUES; BACTERIA; BODY; CHEMICAL REACTIONS; CRYOGENIC FLUIDS; DRUGS; ELEMENTS; FLUIDS; HETEROCYCLIC COMPOUNDS; MICROORGANISMS; NONMETALS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; RESPONSE MODIFYING FACTORS; 560114* - Radiation Effects on Biochemicals- In Animals- (-1987); 560112 - Radiation Effects on Biochemicals- In Microorganisms- (-1987)
OSTI ID:
6188028
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BJCAA
Submitting Site:
INIS
Size:
Pages: 124-128
Announcement Date:

Journal Article:

Citation Formats

Olive, P L, and Durand, R E. Activation of radiosensitizers by hypoxic cells. United Kingdom: N. p., 1978. Web.
Olive, P L, & Durand, R E. Activation of radiosensitizers by hypoxic cells. United Kingdom.
Olive, P L, and Durand, R E. 1978. "Activation of radiosensitizers by hypoxic cells." United Kingdom.
@misc{etde_6188028,
title = {Activation of radiosensitizers by hypoxic cells}
author = {Olive, P L, and Durand, R E}
abstractNote = {Hypoxic cells metabolize nitroheterocyclic compounds to produce toxic intermediates capable of affecting the survival of neighboring oxygenated cells. Mutagenesis experiments with E. coli WP-2 343 (deficient in nitro-reductase) indicated that reduction of nitroheterocyclics outside bacteria causes killing and mutations within bacteria, presumably due to the transfer of the 'active' specie(s). Using animal tissue slices to reduce nitrofurans, cultured L-929 cells incubated under aerobic conditions were far more sensitive to the toxic and DNA damaging effects of these drugs. Transfer of the active species also occurs in a tissue-like environment in multicell spheroids where the presence of a hypoxic central core served to convert the nitroheterocyclics to intermediates which also damaged the neighbouring oxygenated cells.}
journal = {Br. J. Cancer; (United Kingdom)}
volume = {37}
journal type = {AC}
place = {United Kingdom}
year = {1978}
month = {Jun}
}