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Transfer of L-selenomethionine-/sup 75/Se to human milk and the potential radiation dose to a breast-fed infant

Journal Article:

Abstract

Following the administration of L-selenomethionine-/sup 75/Se for a pancreas scan of a lactating mother, it was shown that there was a rapid and high level of incorporation of /sup 75/Se into the breast milk and the milk proteins. Between 5 and 29 hours after injection, the /sup 75/Se concentration in the whole milk and the milk solids decreased by a factor of more than 2; from 29 to 123 hours the concentrations appeared to decrease exponentially with a biological half-time of 78 +- 6 hours. At 123 hours post injection the concentrations of /sup 75/Se in the milk was 68% of that in the maternal plasma. An estimate of the /sup 75/Se intake by the infant was made from the measurements made on the single urine sample obtained 41 hours after the last breast feed. A whole body radiation dose to the infant was estimated to be about 500 ..mu..Gy, i.e. about one-tenth of the ICRP dose equivalent limit for a member of the general public. If breast feeding had been allowed to continue, the whole boent localization tumours and the principles of transferring the experimental data from animals to human beings.
Authors:
Taylor, D M; McCready, V R; Cosgrove, D O [1] 
  1. Heidelberg Univ. (Germany). Lehrstuhl fuer Strahlentoxikologie
Publication Date:
Apr 01, 1981
Product Type:
Journal Article
Reference Number:
AIX-12-616013; EDB-81-124180
Resource Relation:
Journal Name: Nucl. Med. Commun.; (United Kingdom); Journal Volume: 2:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; INFANTS; RADIATION DOSES; MILK; CONTAMINATION; RADIOPHARMACEUTICALS; RISK ASSESSMENT; SELENIUM 75; TISSUE DISTRIBUTION; WOMEN; RADIONUCLIDE KINETICS; LACTATION; METHIONINE; AGE GROUPS; AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BODY FLUIDS; CARBOXYLIC ACIDS; CHILDREN; DAYS LIVING RADIOISOTOPES; DISTRIBUTION; DOSES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; FEMALES; FOOD; INTERMEDIATE MASS NUCLEI; ISOTOPES; LABELLED COMPOUNDS; LIPOTROPIC FACTORS; MAMMALS; MAN; MATERIALS; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PRIMATES; RADIOISOTOPES; SELENIUM ISOTOPES; VERTEBRATES; 560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987); 560151 - Radiation Effects on Animals- Man
OSTI ID:
6186436
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: NMCOD
Submitting Site:
INIS
Size:
Pages: 80-83
Announcement Date:

Journal Article:

Citation Formats

Taylor, D M, McCready, V R, and Cosgrove, D O. Transfer of L-selenomethionine-/sup 75/Se to human milk and the potential radiation dose to a breast-fed infant. United Kingdom: N. p., 1981. Web.
Taylor, D M, McCready, V R, & Cosgrove, D O. Transfer of L-selenomethionine-/sup 75/Se to human milk and the potential radiation dose to a breast-fed infant. United Kingdom.
Taylor, D M, McCready, V R, and Cosgrove, D O. 1981. "Transfer of L-selenomethionine-/sup 75/Se to human milk and the potential radiation dose to a breast-fed infant." United Kingdom.
@misc{etde_6186436,
title = {Transfer of L-selenomethionine-/sup 75/Se to human milk and the potential radiation dose to a breast-fed infant}
author = {Taylor, D M, McCready, V R, and Cosgrove, D O}
abstractNote = {Following the administration of L-selenomethionine-/sup 75/Se for a pancreas scan of a lactating mother, it was shown that there was a rapid and high level of incorporation of /sup 75/Se into the breast milk and the milk proteins. Between 5 and 29 hours after injection, the /sup 75/Se concentration in the whole milk and the milk solids decreased by a factor of more than 2; from 29 to 123 hours the concentrations appeared to decrease exponentially with a biological half-time of 78 +- 6 hours. At 123 hours post injection the concentrations of /sup 75/Se in the milk was 68% of that in the maternal plasma. An estimate of the /sup 75/Se intake by the infant was made from the measurements made on the single urine sample obtained 41 hours after the last breast feed. A whole body radiation dose to the infant was estimated to be about 500 ..mu..Gy, i.e. about one-tenth of the ICRP dose equivalent limit for a member of the general public. If breast feeding had been allowed to continue, the whole boent localization tumours and the principles of transferring the experimental data from animals to human beings.}
journal = {Nucl. Med. Commun.; (United Kingdom)}
volume = {2:2}
journal type = {AC}
place = {United Kingdom}
year = {1981}
month = {Apr}
}