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Thyroid hormones and lipid phosphorus in mice

Journal Article:

Abstract

In vivo studies in mice injected intravenously with /sup 125/I-triiodothyronine (T-3) showed a linear relationship between the uptake of the labelled hormone by the tissue and the lipid phosphorous content of the same tissue. However, studies with /sup 125/I-thyroxine failed to show a similar relationship between the lipid phosphorous content of the organ and the uptake of radioactive hormone by the same organ. In vitro studies using equilibrium dialysis technique with isolated lipid extracts of various organs and radioactive thyroid hormones (T-3 and T-4) did not show any relation between the lipid P and the uptake of labelled hormone. On the basis of the observed discrepancy between in vivo and in vitro studies, it is postulated that an organized lipoprotein structure at the cell membrane may be responsible for the entry of the thyroid hormones.
Authors:
Thakare, U R; Ganatra, R D; Shah, D H [1] 
  1. Bhabha Atomic Research Centre, Bombay (India). Radiation Medicine Centre
Publication Date:
Apr 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-10-423451; EDB-79-101328
Resource Relation:
Journal Name: Indian J. Biochem. Biophys.; (India); Journal Volume: 15:2
Subject:
59 BASIC BIOLOGICAL SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; LIPOPROTEINS; BIOLOGICAL EFFECTS; THYROXINE; MEMBRANE TRANSPORT; TRIIODOTHYRONINE; CELL MEMBRANES; IN VITRO; IN VIVO; INTRAVENOUS INJECTION; IODINE 125; LABELLED COMPOUNDS; LIPIDS; MICE; ORGANS; PHOSPHORUS; TISSUES; TRACER TECHNIQUES; UPTAKE; AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CELL CONSTITUENTS; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTS; HORMONES; INJECTION; INTAKE; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MEMBRANES; NONMETALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; PEPTIDE HORMONES; PROTEINS; RADIOISOTOPES; RODENTS; THYROID HORMONES; VERTEBRATES; 550301* - Cytology- Tracer Techniques; 551001 - Physiological Systems- Tracer Techniques; 550201 - Biochemistry- Tracer Techniques; 550601 - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6185780
Country of Origin:
India
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: IJBBB
Submitting Site:
INIS
Size:
Pages: 137-138
Announcement Date:

Journal Article:

Citation Formats

Thakare, U R, Ganatra, R D, and Shah, D H. Thyroid hormones and lipid phosphorus in mice. India: N. p., 1978. Web.
Thakare, U R, Ganatra, R D, & Shah, D H. Thyroid hormones and lipid phosphorus in mice. India.
Thakare, U R, Ganatra, R D, and Shah, D H. 1978. "Thyroid hormones and lipid phosphorus in mice." India.
@misc{etde_6185780,
title = {Thyroid hormones and lipid phosphorus in mice}
author = {Thakare, U R, Ganatra, R D, and Shah, D H}
abstractNote = {In vivo studies in mice injected intravenously with /sup 125/I-triiodothyronine (T-3) showed a linear relationship between the uptake of the labelled hormone by the tissue and the lipid phosphorous content of the same tissue. However, studies with /sup 125/I-thyroxine failed to show a similar relationship between the lipid phosphorous content of the organ and the uptake of radioactive hormone by the same organ. In vitro studies using equilibrium dialysis technique with isolated lipid extracts of various organs and radioactive thyroid hormones (T-3 and T-4) did not show any relation between the lipid P and the uptake of labelled hormone. On the basis of the observed discrepancy between in vivo and in vitro studies, it is postulated that an organized lipoprotein structure at the cell membrane may be responsible for the entry of the thyroid hormones.}
journal = {Indian J. Biochem. Biophys.; (India)}
volume = {15:2}
journal type = {AC}
place = {India}
year = {1978}
month = {Apr}
}