You need JavaScript to view this

Effects of X-rays on the proliferation dynamics of cells in the imaginal wing disc of Drosophila melanogaster

Journal Article:

Abstract

The size distribution of clones marked by mitotic recombination induced by several different doses of X-rays applied to 72 h old Drosophila larvae is studied. The results indicate that irradiation significantly reduces the number of cells which undergo normal proliferation in the imaginal wing disc. It is estimated that 1000R reduces by 40-60% the number of cells capable of making a normal contribution to the development of the adult wing. Part of this reduction is due to severe curtailment in the proliferative ability of cells which nevertheless remain capable of adult differentiation: this effect is possibly due to radiation-induced aneuploidy. Cytological evidence suggests that immediate cell death also occurs as a result of radiation doses as low as 100R. The surviving cells are stimulated to undergo additional proliferation in response to the X-ray damage so that the result is the differentiation of a normal wing.
Authors:
Haynie, J L; Bryant, P J; [1]  California Univ., Irvine (USA). Center for Pathobiology)
  1. California Univ., Irvine (USA). Dept. of Developmental and Cell Biology
Publication Date:
Jan 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-10-423356; EDB-79-101484
Resource Relation:
Journal Name: Wilhelm Roux' Arch. Dev. Biol.; (Germany, Federal Republic of); Journal Volume: 183:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CELL KILLING; RADIOINDUCTION; CELL PROLIFERATION; BIOLOGICAL RADIATION EFFECTS; LARVAE; ANIMAL CELLS; CLONE CELLS; CYTOLOGY; DROSOPHILA; IRRADIATION; LIMBS; MITOSIS; QUANTITY RATIO; SIZE; SURVIVAL CURVES; X RADIATION; ANIMALS; ARTHROPODS; BIOLOGICAL EFFECTS; BIOLOGY; BODY; BODY AREAS; CELL CULTURES; CELL DIVISION; ELECTROMAGNETIC RADIATION; FLIES; FRUIT FLIES; INSECTS; INVERTEBRATES; IONIZING RADIATIONS; RADIATION EFFECTS; RADIATIONS; 560154* - Radiation Effects on Animals- Basic Studies- (-1987)
OSTI ID:
6184334
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: WRABD
Submitting Site:
INIS
Size:
Pages: 85-100
Announcement Date:
Mar 01, 1979

Journal Article:

Citation Formats

Haynie, J L, Bryant, P J, and California Univ., Irvine (USA). Center for Pathobiology). Effects of X-rays on the proliferation dynamics of cells in the imaginal wing disc of Drosophila melanogaster. Germany: N. p., 1977. Web. doi:10.1007/BF00848779.
Haynie, J L, Bryant, P J, & California Univ., Irvine (USA). Center for Pathobiology). Effects of X-rays on the proliferation dynamics of cells in the imaginal wing disc of Drosophila melanogaster. Germany. doi:10.1007/BF00848779.
Haynie, J L, Bryant, P J, and California Univ., Irvine (USA). Center for Pathobiology). 1977. "Effects of X-rays on the proliferation dynamics of cells in the imaginal wing disc of Drosophila melanogaster." Germany. doi:10.1007/BF00848779. https://www.osti.gov/servlets/purl/10.1007/BF00848779.
@misc{etde_6184334,
title = {Effects of X-rays on the proliferation dynamics of cells in the imaginal wing disc of Drosophila melanogaster}
author = {Haynie, J L, Bryant, P J, and California Univ., Irvine (USA). Center for Pathobiology)}
abstractNote = {The size distribution of clones marked by mitotic recombination induced by several different doses of X-rays applied to 72 h old Drosophila larvae is studied. The results indicate that irradiation significantly reduces the number of cells which undergo normal proliferation in the imaginal wing disc. It is estimated that 1000R reduces by 40-60% the number of cells capable of making a normal contribution to the development of the adult wing. Part of this reduction is due to severe curtailment in the proliferative ability of cells which nevertheless remain capable of adult differentiation: this effect is possibly due to radiation-induced aneuploidy. Cytological evidence suggests that immediate cell death also occurs as a result of radiation doses as low as 100R. The surviving cells are stimulated to undergo additional proliferation in response to the X-ray damage so that the result is the differentiation of a normal wing.}
doi = {10.1007/BF00848779}
journal = {Wilhelm Roux' Arch. Dev. Biol.; (Germany, Federal Republic of)}
volume = {183:2}
journal type = {AC}
place = {Germany}
year = {1977}
month = {Jan}
}