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Sup(99m)Tc-Sn-pyrophosphate complex. A stable, lyophilized radiopharmaceutical for skeletal scanning

Journal Article:

Abstract

After a systematic investigation of the different phosphate polymers, viz. hexametaphosphate, tripolyphosphate, meta- and diphosphonate, pyrophosphate (Na/sub 4/P/sub 2/O/sub 7/) was selected for sceletal scintigraphy. A procedure has been developed for obtaining a sup(99m)Tc-labelled Sn(II): PyP complex by addition of a sterile, apyrogenic pertechnetate solution from a sup(99m)Tc-generator to a lyophilized solution of Sn(II)-tetrasodium phosphate. ''Kit'' composition was determined on the basis of biodynamic data obtained when the Sn/pyrophosphate ratio, pH and other parameters were varied. In vivo distribution of different sup(99m)Tc-Sn-pyrophosphate complexes permitted the selection of the most suitable complex for sceletal scanning. The investigated complex is being successfully applied in human scintigraphy of bones in the Laboratory for Radioisotope Applications of the Institute for Tubercolosis and Pectoral Diseases in Sremska Kamenica.
Authors:
Cvoric, J; Jovanovic, V; Bzenic, J; [1]  Stefanovic, Lj; Selir, Z [2] 
  1. Institut za Nuklearne Nauke Boris Kidric, Belgrade (Yugoslavia)
  2. Institute for Tuberculosis and Pectoral Diseases, Radioisotope Applications, Sremska Kamenica (Yugoslavia)
Publication Date:
Jan 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-10-436420; EDB-79-074498
Resource Relation:
Journal Name: J. Radioanal. Chem.; (Hungary); Journal Volume: 44:2
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; TECHNETIUM COMPLEXES; LABELLING; TIN COMPLEXES; LYOPHILIZATION; PYROPHOSPHATES; SCINTISCANNING; TECHNETIUM 99; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; COMPLEXES; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; NUCLEI; ODD-EVEN NUCLEI; OXYGEN COMPOUNDS; PHOSPHORUS COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SYNTHESIS; TECHNETIUM ISOTOPES; TRANSITION ELEMENT COMPLEXES; YEARS LIVING RADIOISOTOPES; 400700* - Radiochemistry & Nuclear Chemistry
OSTI ID:
6183455
Country of Origin:
Hungary
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JRACB
Submitting Site:
INIS
Size:
Pages: 265-269
Announcement Date:
May 01, 1979

Journal Article:

Citation Formats

Cvoric, J, Jovanovic, V, Bzenic, J, Stefanovic, Lj, and Selir, Z. Sup(99m)Tc-Sn-pyrophosphate complex. A stable, lyophilized radiopharmaceutical for skeletal scanning. Hungary: N. p., 1978. Web.
Cvoric, J, Jovanovic, V, Bzenic, J, Stefanovic, Lj, & Selir, Z. Sup(99m)Tc-Sn-pyrophosphate complex. A stable, lyophilized radiopharmaceutical for skeletal scanning. Hungary.
Cvoric, J, Jovanovic, V, Bzenic, J, Stefanovic, Lj, and Selir, Z. 1978. "Sup(99m)Tc-Sn-pyrophosphate complex. A stable, lyophilized radiopharmaceutical for skeletal scanning." Hungary.
@misc{etde_6183455,
title = {Sup(99m)Tc-Sn-pyrophosphate complex. A stable, lyophilized radiopharmaceutical for skeletal scanning}
author = {Cvoric, J, Jovanovic, V, Bzenic, J, Stefanovic, Lj, and Selir, Z}
abstractNote = {After a systematic investigation of the different phosphate polymers, viz. hexametaphosphate, tripolyphosphate, meta- and diphosphonate, pyrophosphate (Na/sub 4/P/sub 2/O/sub 7/) was selected for sceletal scintigraphy. A procedure has been developed for obtaining a sup(99m)Tc-labelled Sn(II): PyP complex by addition of a sterile, apyrogenic pertechnetate solution from a sup(99m)Tc-generator to a lyophilized solution of Sn(II)-tetrasodium phosphate. ''Kit'' composition was determined on the basis of biodynamic data obtained when the Sn/pyrophosphate ratio, pH and other parameters were varied. In vivo distribution of different sup(99m)Tc-Sn-pyrophosphate complexes permitted the selection of the most suitable complex for sceletal scanning. The investigated complex is being successfully applied in human scintigraphy of bones in the Laboratory for Radioisotope Applications of the Institute for Tubercolosis and Pectoral Diseases in Sremska Kamenica.}
journal = {J. Radioanal. Chem.; (Hungary)}
volume = {44:2}
journal type = {AC}
place = {Hungary}
year = {1978}
month = {Jan}
}