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Radioimmunoassay of an early plasmin degradation product of human fibrinogen, 'fragment A', and its clinical application

Journal Article:

Abstract

Upon the plasmin digestion of human fibrinogen, an early cleavage product, which has been designated as fragment A, was isolated, and to study the action of plasmin in the circulation, radioimmunoassay for fragment A was carried out. This assay used rabbit immune serum obtained by injection of fragment A mixed with complete Freund's adjuvant, and fragment A was labelled with /sup 125/I using the Chloramin-T method. In 20 normal healthy donors its serum level was 3.57 +- 1.62..mu..g/ml (mean+-SD), and it was increased significantly in certain diseases, such as acute leukemias, candiovascular disorders, malignancies, renal failure, systemic lupus erythematosus and sepsis.
Authors:
Takagi, K; Kawai, T [1] 
  1. Jichi Medical School, Kawachi, Tochigi (Japan)
Publication Date:
Feb 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-10-449085; EDB-79-075294
Resource Relation:
Journal Name: Thromb. Haemost.; (Germany, Federal Republic of); Journal Volume: 39:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD SERUM; BIOCHEMICAL REACTION KINETICS; FIBRINOGEN; RADIOIMMUNOASSAY; DIAGNOSIS; DISEASES; IODINE 125; LABELLED COMPOUNDS; MAN; ORGANS; ANIMALS; BETA DECAY RADIOISOTOPES; BLOOD COAGULATION FACTORS; BODY; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; GLOBULINS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; KINETICS; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PRIMATES; PROTEINS; RADIOASSAY; RADIOISOTOPES; REACTION KINETICS; TRACER TECHNIQUES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6180477
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: THHAD
Submitting Site:
INIS
Size:
Pages: 1-11
Announcement Date:
May 01, 1979

Journal Article:

Citation Formats

Takagi, K, and Kawai, T. Radioimmunoassay of an early plasmin degradation product of human fibrinogen, 'fragment A', and its clinical application. Germany: N. p., 1978. Web.
Takagi, K, & Kawai, T. Radioimmunoassay of an early plasmin degradation product of human fibrinogen, 'fragment A', and its clinical application. Germany.
Takagi, K, and Kawai, T. 1978. "Radioimmunoassay of an early plasmin degradation product of human fibrinogen, 'fragment A', and its clinical application." Germany.
@misc{etde_6180477,
title = {Radioimmunoassay of an early plasmin degradation product of human fibrinogen, 'fragment A', and its clinical application}
author = {Takagi, K, and Kawai, T}
abstractNote = {Upon the plasmin digestion of human fibrinogen, an early cleavage product, which has been designated as fragment A, was isolated, and to study the action of plasmin in the circulation, radioimmunoassay for fragment A was carried out. This assay used rabbit immune serum obtained by injection of fragment A mixed with complete Freund's adjuvant, and fragment A was labelled with /sup 125/I using the Chloramin-T method. In 20 normal healthy donors its serum level was 3.57 +- 1.62..mu..g/ml (mean+-SD), and it was increased significantly in certain diseases, such as acute leukemias, candiovascular disorders, malignancies, renal failure, systemic lupus erythematosus and sepsis.}
journal = {Thromb. Haemost.; (Germany, Federal Republic of)}
volume = {39:1}
journal type = {AC}
place = {Germany}
year = {1978}
month = {Feb}
}