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Stimulatory effect of the D2 antagonist sulpiride on glucose utilization in dopaminergic regions of rat brain

Abstract

Local cerebral glucose utilization (LCGU) was measured, using the quantitative autoradiographic (/sup 14/C)2-deoxy-D-glucose method, in 56 brain regions of 3-month-old, awake Fischer-344 rats, after intraperitoneal administration of sulpiride (SULP) 100 mg/kg. SULP, an atypical neuroleptic, is a selective antagonist of D2 dopamine receptors. LCGU was reduced in a few nondopaminergic regions at 1 h after drug administration. Thereafter, SULP progressively elevated LCGU in many other regions. At 3 h, LCGU was elevated in 23% of the regions examined, most of which are related to the CNS dopaminergic system (caudate-putamen, nucleus accumbens, olfactory tubercle, lateral habenula, median eminence, paraventricular hypothalamic nucleus). Increases of LCGU were observed also in the suprachiasmatic nucleus, lateral geniculate, and inferior olive. These effects of SULP on LCGU differ from the effects of the typical neuroleptic haloperidol, which produces widespread decreases in LCGU in the rat brain. Selective actions on different subpopulations of dopamine receptors may explain the different effects of the two neuroleptics on brain metabolism, which correspond to their different clinical and behavioral actions.
Publication Date:
Aug 01, 1987
Product Type:
Journal Article
Reference Number:
EDB-87-159086
Resource Relation:
Journal Name: J. Neurochem.; (United Kingdom); Journal Volume: 49:2
Subject:
59 BASIC BIOLOGICAL SCIENCES; DOPAMINE; RECEPTORS; GLUCOSE; METABOLISM; SYMPATHOLYTICS; BIOCHEMICAL REACTION KINETICS; AUTORADIOGRAPHY; BRAIN; CARBON 14 COMPOUNDS; RATS; ALDEHYDES; AMINES; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BODY; CARBOHYDRATES; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; DRUGS; HEXOSES; HYDROXY COMPOUNDS; KINETICS; LABELLED COMPOUNDS; MAMMALS; MEMBRANE PROTEINS; MONOSACCHARIDES; NERVOUS SYSTEM; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; PROTEINS; REACTION KINETICS; RODENTS; SACCHARIDES; SYMPATHOMIMETICS; VERTEBRATES; 550501* - Metabolism- Tracer Techniques
OSTI ID:
6178894
Research Organizations:
National Institute on Aging, Bethesda, MD
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JONRA
Submitting Site:
NLM
Size:
Pages: 631-638
Announcement Date:
Sep 01, 1987

Citation Formats

Pizzolato, G, Soncrant, T T, Larson, D M, and Rapoport, S I. Stimulatory effect of the D2 antagonist sulpiride on glucose utilization in dopaminergic regions of rat brain. United Kingdom: N. p., 1987. Web. doi:10.1111/j.1471-4159.1987.tb02910.x.
Pizzolato, G, Soncrant, T T, Larson, D M, & Rapoport, S I. Stimulatory effect of the D2 antagonist sulpiride on glucose utilization in dopaminergic regions of rat brain. United Kingdom. doi:10.1111/j.1471-4159.1987.tb02910.x.
Pizzolato, G, Soncrant, T T, Larson, D M, and Rapoport, S I. 1987. "Stimulatory effect of the D2 antagonist sulpiride on glucose utilization in dopaminergic regions of rat brain." United Kingdom. doi:10.1111/j.1471-4159.1987.tb02910.x. https://www.osti.gov/servlets/purl/10.1111/j.1471-4159.1987.tb02910.x.
@misc{etde_6178894,
title = {Stimulatory effect of the D2 antagonist sulpiride on glucose utilization in dopaminergic regions of rat brain}
author = {Pizzolato, G, Soncrant, T T, Larson, D M, and Rapoport, S I}
abstractNote = {Local cerebral glucose utilization (LCGU) was measured, using the quantitative autoradiographic (/sup 14/C)2-deoxy-D-glucose method, in 56 brain regions of 3-month-old, awake Fischer-344 rats, after intraperitoneal administration of sulpiride (SULP) 100 mg/kg. SULP, an atypical neuroleptic, is a selective antagonist of D2 dopamine receptors. LCGU was reduced in a few nondopaminergic regions at 1 h after drug administration. Thereafter, SULP progressively elevated LCGU in many other regions. At 3 h, LCGU was elevated in 23% of the regions examined, most of which are related to the CNS dopaminergic system (caudate-putamen, nucleus accumbens, olfactory tubercle, lateral habenula, median eminence, paraventricular hypothalamic nucleus). Increases of LCGU were observed also in the suprachiasmatic nucleus, lateral geniculate, and inferior olive. These effects of SULP on LCGU differ from the effects of the typical neuroleptic haloperidol, which produces widespread decreases in LCGU in the rat brain. Selective actions on different subpopulations of dopamine receptors may explain the different effects of the two neuroleptics on brain metabolism, which correspond to their different clinical and behavioral actions.}
doi = {10.1111/j.1471-4159.1987.tb02910.x}
journal = {J. Neurochem.; (United Kingdom)}
volume = {49:2}
journal type = {AC}
place = {United Kingdom}
year = {1987}
month = {Aug}
}