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Enhanced killing of mammalian cells by radiation combined with m-AMSA

Journal Article:

Abstract

m-AMSA is an intercalating agent at present on Phase II trial as a chemotherapeutic drug. A 30 min exposure of Chinese hamster (Line V79-753B) cells to submicromolar concentrations of m-AMSA killed 50% of the cells. The survivors had an enhanced sensitivity to radiation-induced cell killing. Depending upon the conditions, m-AMSA enhanced the radiation effect by either a decrease in the survival-curve shoulder or by an increase in slope. m-AMSA may act partly by suppressing the accumulation of sublethal damage but, if so, recovery from damage as measured in split-dose experiments with cells pretreated with the drug is not affected. m-AMSA increased radiation lethality throughout the cell cycle, but a contribution to its radiation effect from selective toxicity to cells in a radioresistant phase of the cell cycle cannot be excluded. Radiation and the drug interacted to give increased cell killing, even when the exposures to each agent were separated in time. It is concluded that m-ASMA may behave like actinomycin D and adriamycin, and enhance clinical radiation responses. In vivo testing to determine the effect of m-AMSA on the therapeutic index is recommended.
Authors:
Roberts, P B; Millar, B C [1] 
  1. Institute of Cancer Research, Sutton (UK). Surrey Branch
Publication Date:
Nov 01, 1980
Product Type:
Journal Article
Reference Number:
AIX-12-609947; EDB-81-131985
Resource Relation:
Journal Name: Br. J. Cancer; (United Kingdom); Journal Volume: 42:5
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ACRIDINES; RADIOSENSITIVITY EFFECTS; ANIMAL CELLS; RADIOSENSITIVITY; CELL CYCLE; CELL KILLING; CHEMOTHERAPY; FRACTIONATED IRRADIATION; HAMSTERS; IN VITRO; RADIOSENSITIZERS; SUBLETHAL IRRADIATION; SURVIVAL CURVES; ANIMALS; AZINES; DRUGS; HETEROCYCLIC COMPOUNDS; IRRADIATION; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIDINES; RODENTS; THERAPY; VERTEBRATES; 560121* - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
6171862
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BJCAA
Submitting Site:
INIS
Size:
Pages: 684-691
Announcement Date:

Journal Article:

Citation Formats

Roberts, P B, and Millar, B C. Enhanced killing of mammalian cells by radiation combined with m-AMSA. United Kingdom: N. p., 1980. Web.
Roberts, P B, & Millar, B C. Enhanced killing of mammalian cells by radiation combined with m-AMSA. United Kingdom.
Roberts, P B, and Millar, B C. 1980. "Enhanced killing of mammalian cells by radiation combined with m-AMSA." United Kingdom.
@misc{etde_6171862,
title = {Enhanced killing of mammalian cells by radiation combined with m-AMSA}
author = {Roberts, P B, and Millar, B C}
abstractNote = {m-AMSA is an intercalating agent at present on Phase II trial as a chemotherapeutic drug. A 30 min exposure of Chinese hamster (Line V79-753B) cells to submicromolar concentrations of m-AMSA killed 50% of the cells. The survivors had an enhanced sensitivity to radiation-induced cell killing. Depending upon the conditions, m-AMSA enhanced the radiation effect by either a decrease in the survival-curve shoulder or by an increase in slope. m-AMSA may act partly by suppressing the accumulation of sublethal damage but, if so, recovery from damage as measured in split-dose experiments with cells pretreated with the drug is not affected. m-AMSA increased radiation lethality throughout the cell cycle, but a contribution to its radiation effect from selective toxicity to cells in a radioresistant phase of the cell cycle cannot be excluded. Radiation and the drug interacted to give increased cell killing, even when the exposures to each agent were separated in time. It is concluded that m-ASMA may behave like actinomycin D and adriamycin, and enhance clinical radiation responses. In vivo testing to determine the effect of m-AMSA on the therapeutic index is recommended.}
journal = {Br. J. Cancer; (United Kingdom)}
volume = {42:5}
journal type = {AC}
place = {United Kingdom}
year = {1980}
month = {Nov}
}