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Gonadal cell kinetics in male mice treated with sulphur-35 during prenatal development

Journal Article:

Abstract

Investigations on the possible hazards of the use of internally administered radioisotopes in human medicine either as therapeutic or diagnostic agents before or during child bearing age are of late gaining importance. The present investigation has been taken up to screen the effects of sulphur-35 on spermatogonia. CBA pregnant mice were injected (ip) with a dose of 20 ..mu.. Ci of sulphur-35 on 3.5, 10.5 or 15.5 days of gestation. At the similar intervals pregnant mice injected with physiological saline were kept for control data. All the animals were allowed to litter and F/sub 1/ male progeny were killed at maturity at the age of 10 weeks and the testes collected. Sections of both the testes were prepared and stained by PAS-haematoxylin technique and the survival of spermatogonia types A, Int and B and preleptotene spermatocytes was evaluated. There was a significant reduction in all the cell types in the sulphur-35 treated animals. Thus the results indicate the cell-killing effect of radionuclide.
Authors:
Satyanarayana Reddy, K; Reddy, P P; Reddi, O S [1] 
  1. Osmania Univ., Hyderabad (India). Inst. of Genetics
Publication Date:
Nov 01, 1980
Product Type:
Journal Article
Reference Number:
AIX-12-632375; EDB-81-132184
Resource Relation:
Journal Name: Proc. - Indian Acad. Sci. (Ser.): Anim. Sci.; (India); Journal Volume: 89:6; Other Information: 14 refs
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; PRENATAL IRRADIATION; BIOLOGICAL RADIATION EFFECTS; SULFUR 35; CELL KILLING; CARRIER-FREE ISOTOPES; EMBRYOS; INTRAPERITONEAL INJECTION; LABELLED COMPOUNDS; MICE; PREGNANCY; RADIONUCLIDE ADMINISTRATION; SODIUM SULFATES; SPERMATOCYTES; SPERMATOGONIA; TESTES; ALKALI METAL COMPOUNDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BODY; DAYS LIVING RADIOISOTOPES; EVEN-ODD NUCLEI; GAMETES; GERM CELLS; GONADS; INJECTION; INTAKE; IRRADIATION; ISOTOPES; LIGHT NUCLEI; MALE GENITALS; MAMMALS; NUCLEI; ORGANS; OXYGEN COMPOUNDS; PRENATAL EXPOSURE; RADIATION EFFECTS; RADIOISOTOPES; RODENTS; SODIUM COMPOUNDS; SULFATES; SULFUR COMPOUNDS; SULFUR ISOTOPES; VERTEBRATES; 560162* - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells
OSTI ID:
6171004
Country of Origin:
India
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: PIAND
Submitting Site:
INIS
Size:
Pages: 527-530
Announcement Date:
Oct 01, 1981

Journal Article:

Citation Formats

Satyanarayana Reddy, K, Reddy, P P, and Reddi, O S. Gonadal cell kinetics in male mice treated with sulphur-35 during prenatal development. India: N. p., 1980. Web.
Satyanarayana Reddy, K, Reddy, P P, & Reddi, O S. Gonadal cell kinetics in male mice treated with sulphur-35 during prenatal development. India.
Satyanarayana Reddy, K, Reddy, P P, and Reddi, O S. 1980. "Gonadal cell kinetics in male mice treated with sulphur-35 during prenatal development." India.
@misc{etde_6171004,
title = {Gonadal cell kinetics in male mice treated with sulphur-35 during prenatal development}
author = {Satyanarayana Reddy, K, Reddy, P P, and Reddi, O S}
abstractNote = {Investigations on the possible hazards of the use of internally administered radioisotopes in human medicine either as therapeutic or diagnostic agents before or during child bearing age are of late gaining importance. The present investigation has been taken up to screen the effects of sulphur-35 on spermatogonia. CBA pregnant mice were injected (ip) with a dose of 20 ..mu.. Ci of sulphur-35 on 3.5, 10.5 or 15.5 days of gestation. At the similar intervals pregnant mice injected with physiological saline were kept for control data. All the animals were allowed to litter and F/sub 1/ male progeny were killed at maturity at the age of 10 weeks and the testes collected. Sections of both the testes were prepared and stained by PAS-haematoxylin technique and the survival of spermatogonia types A, Int and B and preleptotene spermatocytes was evaluated. There was a significant reduction in all the cell types in the sulphur-35 treated animals. Thus the results indicate the cell-killing effect of radionuclide.}
journal = {Proc. - Indian Acad. Sci. (Ser.): Anim. Sci.; (India)}
volume = {89:6}
journal type = {AC}
place = {India}
year = {1980}
month = {Nov}
}