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Biochemical studies of the macromolecular matrix of long bones in the Op/Orl mutant rat strain

Journal Article:

Abstract

The long bones of normal and Op/Orl mutant rats were incubated with /sup 14/C-glucose and fractionated by EDTA and urea extraction. The analytical results of the various extracts suggested an increase in structural glycoprotein content and a decrease in collagen solubility in the long bones of mutants. Significant differences were found in the organic matrix composition of male and female bones of the two strains. /sup 14/C-glucose incorporation was stronger in males than in females. The presence of a glycosaminoglycan different from the chondroitinesulfate was shown in males. Basic amino acid content (lysine, arginine, histidine) was clearly higher in the insoluble residue of male bones .
Publication Date:
Jan 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-09-414611; EDB-79-064934
Resource Relation:
Journal Name: Ann. Biol. Anim. Biochim., Biophys.; (France); Journal Volume: 18:1
Subject:
59 BASIC BIOLOGICAL SCIENCES; BONE TISSUES; BIOCHEMISTRY; AMINO ACIDS; CARBON 14 COMPOUNDS; CHONDROITIN; COLLAGEN; EDTA; GLUCOPROTEINS; GLUCOSE; METABOLISM; MUTANTS; RATS; SEX DEPENDENCE; TISSUE EXTRACTS; TRACER TECHNIQUES; UREA; ALDEHYDES; AMIDES; AMINES; ANIMALS; BIOLOGICAL MATERIALS; BODY; CARBOHYDRATES; CARBONIC ACID DERIVATIVES; CARBOXYLIC ACIDS; CHELATING AGENTS; CHEMISTRY; CONNECTIVE TISSUE; HEXOSES; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; MONOSACCHARIDES; MUCOPOLYSACCHARIDES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; POLYSACCHARIDES; PROTEINS; RODENTS; SACCHARIDES; SCLEROPROTEINS; TISSUES; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques
OSTI ID:
6165893
Country of Origin:
France
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ABABA
Submitting Site:
INIS
Size:
Pages: 137-141
Announcement Date:
Jan 01, 1979

Journal Article:

Citation Formats

Moczar, E, Berenholc, S, Phan-Dinh-Tuy, B, and Robert, A M. Biochemical studies of the macromolecular matrix of long bones in the Op/Orl mutant rat strain. France: N. p., 1978. Web.
Moczar, E, Berenholc, S, Phan-Dinh-Tuy, B, & Robert, A M. Biochemical studies of the macromolecular matrix of long bones in the Op/Orl mutant rat strain. France.
Moczar, E, Berenholc, S, Phan-Dinh-Tuy, B, and Robert, A M. 1978. "Biochemical studies of the macromolecular matrix of long bones in the Op/Orl mutant rat strain." France.
@misc{etde_6165893,
title = {Biochemical studies of the macromolecular matrix of long bones in the Op/Orl mutant rat strain}
author = {Moczar, E, Berenholc, S, Phan-Dinh-Tuy, B, and Robert, A M}
abstractNote = {The long bones of normal and Op/Orl mutant rats were incubated with /sup 14/C-glucose and fractionated by EDTA and urea extraction. The analytical results of the various extracts suggested an increase in structural glycoprotein content and a decrease in collagen solubility in the long bones of mutants. Significant differences were found in the organic matrix composition of male and female bones of the two strains. /sup 14/C-glucose incorporation was stronger in males than in females. The presence of a glycosaminoglycan different from the chondroitinesulfate was shown in males. Basic amino acid content (lysine, arginine, histidine) was clearly higher in the insoluble residue of male bones .}
journal = {Ann. Biol. Anim. Biochim., Biophys.; (France)}
volume = {18:1}
journal type = {AC}
place = {France}
year = {1978}
month = {Jan}
}