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New radioactively labelled amines, procedure of preparation of the new compounds as well as the diagnostic preparations based on these new compounds

Abstract

This patent describes the composition and preparation of new radioactively labelled amine conpounds for use as radiopharmaceuticals, particularly for the detection and/or localization of thrombi in the body. They are not alien to the body, are used to trace the fibrin network, and lead to favourable ratios between the presence of radioactivity in the blood clot and that in the rest of the body. These new compounds have the general formula Y - (CH/sub 2/)/sub 2/-X-(CH/sub 2/)/sub 2/ - NH/sub 2/ in which X is an oxygen or sulfur atom or a methylene, ethylene or trimethylene group and Y is an organic molecule labelled with radioactive iodine, or in which X is a radioactively labelled selenium or tellurium atom and Y is an organic molecule.
Authors:
Publication Date:
Feb 07, 1979
Product Type:
Patent
Report Number:
NL 7900964; A
Reference Number:
AIX-12-601697; EDB-81-111426
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; 62 RADIOLOGY AND NUCLEAR MEDICINE; AMINES; LABELLING; RADIOPHARMACEUTICALS; BLOOD COAGULATION; CHEMICAL COMPOSITION; CHEMICAL PREPARATION; FIBRIN; IODINE ISOTOPES; SELENIUM ISOTOPES; TELLURIUM ISOTOPES; THROMBIN; THROMBOSIS; CARDIOVASCULAR DISEASES; COAGULANTS; DISEASES; DRUGS; ENZYMES; HEMATOLOGIC AGENTS; HEMOSTATICS; HYDROLASES; ISOTOPES; LABELLED COMPOUNDS; ORGANIC COMPOUNDS; PEPTIDE HYDROLASES; PROTEINS; SCLEROPROTEINS; SERINE PROTEINASES; SYNTHESIS; VASCULAR DISEASES; 400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials; 550601 - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6165870
Country of Origin:
Netherlands
Language:
Dutch
Submitting Site:
INIS
Size:
Pages: 15
Announcement Date:

Citation Formats

Not Available. New radioactively labelled amines, procedure of preparation of the new compounds as well as the diagnostic preparations based on these new compounds. Netherlands: N. p., 1979. Web.
Not Available. New radioactively labelled amines, procedure of preparation of the new compounds as well as the diagnostic preparations based on these new compounds. Netherlands.
Not Available. 1979. "New radioactively labelled amines, procedure of preparation of the new compounds as well as the diagnostic preparations based on these new compounds." Netherlands.
@misc{etde_6165870,
title = {New radioactively labelled amines, procedure of preparation of the new compounds as well as the diagnostic preparations based on these new compounds}
author = {Not Available}
abstractNote = {This patent describes the composition and preparation of new radioactively labelled amine conpounds for use as radiopharmaceuticals, particularly for the detection and/or localization of thrombi in the body. They are not alien to the body, are used to trace the fibrin network, and lead to favourable ratios between the presence of radioactivity in the blood clot and that in the rest of the body. These new compounds have the general formula Y - (CH/sub 2/)/sub 2/-X-(CH/sub 2/)/sub 2/ - NH/sub 2/ in which X is an oxygen or sulfur atom or a methylene, ethylene or trimethylene group and Y is an organic molecule labelled with radioactive iodine, or in which X is a radioactively labelled selenium or tellurium atom and Y is an organic molecule.}
place = {Netherlands}
year = {1979}
month = {Feb}
}