Abstract
The therapeutic efficacy of a scheme of polyradiomodification with metronidazole (MZ) administration was investigated in experiments on mice with Ehrlich carcinoma before local irradiation of tumors and with subsequent induced hyperglycemia (IH) depending on a MZ dose. For equally effective potentiation of the effect of radiation on a tumor during a combined use of MZ and postradiation IH a 4-fold lower dose of the drug was required as combined to MZ used alone. The combined effect of the modifiers was superadditive. The use of IH in this scheme not only potentiated skin radiation reactions on a tumor growth zone but also slighly weakened their expression.
Vinskaya, N P;
Voloshina, E A;
Kozin, S V
[1]
- Akademiya Meditsinskikh Nauk SSSR, Moscow (USSR). Onkologicheskij Nauchnyj Tsentr
Citation Formats
Vinskaya, N P, Voloshina, E A, and Kozin, S V.
Possibilities of the reduction of a dose of metronidazole during irradiation of tumor with subsequent induced hyperglycemia. Vozmozhnost' snizheniya dozy metronidazola pri obluchenii opukholej s posleduyushchej iskusstvennoj giperglikemiej.
USSR: N. p.,
1989.
Web.
Vinskaya, N P, Voloshina, E A, & Kozin, S V.
Possibilities of the reduction of a dose of metronidazole during irradiation of tumor with subsequent induced hyperglycemia. Vozmozhnost' snizheniya dozy metronidazola pri obluchenii opukholej s posleduyushchej iskusstvennoj giperglikemiej.
USSR.
Vinskaya, N P, Voloshina, E A, and Kozin, S V.
1989.
"Possibilities of the reduction of a dose of metronidazole during irradiation of tumor with subsequent induced hyperglycemia. Vozmozhnost' snizheniya dozy metronidazola pri obluchenii opukholej s posleduyushchej iskusstvennoj giperglikemiej."
USSR.
@misc{etde_6156422,
title = {Possibilities of the reduction of a dose of metronidazole during irradiation of tumor with subsequent induced hyperglycemia. Vozmozhnost' snizheniya dozy metronidazola pri obluchenii opukholej s posleduyushchej iskusstvennoj giperglikemiej}
author = {Vinskaya, N P, Voloshina, E A, and Kozin, S V}
abstractNote = {The therapeutic efficacy of a scheme of polyradiomodification with metronidazole (MZ) administration was investigated in experiments on mice with Ehrlich carcinoma before local irradiation of tumors and with subsequent induced hyperglycemia (IH) depending on a MZ dose. For equally effective potentiation of the effect of radiation on a tumor during a combined use of MZ and postradiation IH a 4-fold lower dose of the drug was required as combined to MZ used alone. The combined effect of the modifiers was superadditive. The use of IH in this scheme not only potentiated skin radiation reactions on a tumor growth zone but also slighly weakened their expression.}
journal = []
volume = {10}
journal type = {AC}
place = {USSR}
year = {1989}
month = {Oct}
}
title = {Possibilities of the reduction of a dose of metronidazole during irradiation of tumor with subsequent induced hyperglycemia. Vozmozhnost' snizheniya dozy metronidazola pri obluchenii opukholej s posleduyushchej iskusstvennoj giperglikemiej}
author = {Vinskaya, N P, Voloshina, E A, and Kozin, S V}
abstractNote = {The therapeutic efficacy of a scheme of polyradiomodification with metronidazole (MZ) administration was investigated in experiments on mice with Ehrlich carcinoma before local irradiation of tumors and with subsequent induced hyperglycemia (IH) depending on a MZ dose. For equally effective potentiation of the effect of radiation on a tumor during a combined use of MZ and postradiation IH a 4-fold lower dose of the drug was required as combined to MZ used alone. The combined effect of the modifiers was superadditive. The use of IH in this scheme not only potentiated skin radiation reactions on a tumor growth zone but also slighly weakened their expression.}
journal = []
volume = {10}
journal type = {AC}
place = {USSR}
year = {1989}
month = {Oct}
}