You need JavaScript to view this

Instrument performance in bone density testing at five Australian centres

Abstract

Using a multicentre reliability study the accuracy and short- and long-term precision of dual-energy X-ray absorptiometry (DXA) in vitro was compared on five instruments. Measures were performed using pencil beam mode on four Hologic QDR- 2000 densitometers and one Hologic QDR-1000/W (Hologic Inc, Waltham, MA). Short-term precision of bone mineral density measurement was less than 0.5% for spine phantoms (n= 10 for each centre, mean intrasite coefficient of variation [CV] 0.39{+-}0.09% [SD]) and for hip phantoms (n=10 for each centre, mean intrasite coefficient of variation [CV] 0.34{+-}0.10% [SD]). Between-centre measurement (n=10 for each phantom) of a single spine phantom and a single hip phantom (specified mineral contents - 58.5 g and 38.6 g, respectively) revealed ranges of bone mineral content of 57.7-58.1 g (all-point CV=0.52%) and 37.1-37.8 g (all-point CV=0.70%), respectively. When results from pairs of machines were compared there were statistically different mean BMD results for the majority of the ten possible pairings for both spine and hip measurements. Each study centre measured in vitro stability of phantom BMD measurements over a one year period (n=45-283, median 157 for spine; and n=0-262, median 38, for hip); CVs ranged from 0.38 % to 0.53% for the spine measurements and from  More>>
Authors:
Khan, K M; Saul, A; Wark, J D; [1]  Henzell, S L; [2]  Broderick, C; [3]  Prince, R L; [4]  Lomman, J [5] 
  1. Royal Melbourne Hospital, Parkville, VIC (Australia). Department of Medicine
  2. Charles Gairdner Hospital, Perth, WA (Australia). Department of Endocrinology and Diabetes
  3. University of NSW, Sydney, NSW (Australia)
  4. University of Western Australia, Perth, WA. (Australia). Department of Medicine
  5. Bone Densitometry Technologist, Ashford, SA (Australia)
Publication Date:
Oct 01, 1997
Product Type:
Journal Article
Reference Number:
SCA: 550602; 440101; PA: AIX-29:033037; EDB-98:069492; SN: 98001971393
Resource Relation:
Journal Name: Australian and New Zealand Journal of Medicine; Journal Volume: 27; Journal Issue: 5; Other Information: DN: 14 refs., 3 tabs., 4 figs.; PBD: Oct 1997
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; 44 INSTRUMENTATION, INCLUDING NUCLEAR AND PARTICLE DETECTORS; ACCURACY; COMPARATIVE EVALUATIONS; DENSITOMETERS; DUAL ABSORPTION MODEL; EVALUATED DATA; IN VIVO; INTERLABORATORY COMPARISONS; LEGS; OSTEODENSITOMETRY; PHANTOMS; SENSITIVITY; STATISTICS; VERTEBRAE; X-RAY RADIOGRAPHY
OSTI ID:
615124
Country of Origin:
Australia
Language:
English
Other Identifying Numbers:
Journal ID: ANZJB8; ISSN 0004-8291; TRN: AU9817187033037
Submitting Site:
AUN
Size:
pp. 526-530
Announcement Date:
Jun 30, 1998

Citation Formats

Khan, K M, Saul, A, Wark, J D, Henzell, S L, Broderick, C, Prince, R L, and Lomman, J. Instrument performance in bone density testing at five Australian centres. Australia: N. p., 1997. Web.
Khan, K M, Saul, A, Wark, J D, Henzell, S L, Broderick, C, Prince, R L, & Lomman, J. Instrument performance in bone density testing at five Australian centres. Australia.
Khan, K M, Saul, A, Wark, J D, Henzell, S L, Broderick, C, Prince, R L, and Lomman, J. 1997. "Instrument performance in bone density testing at five Australian centres." Australia.
@misc{etde_615124,
title = {Instrument performance in bone density testing at five Australian centres}
author = {Khan, K M, Saul, A, Wark, J D, Henzell, S L, Broderick, C, Prince, R L, and Lomman, J}
abstractNote = {Using a multicentre reliability study the accuracy and short- and long-term precision of dual-energy X-ray absorptiometry (DXA) in vitro was compared on five instruments. Measures were performed using pencil beam mode on four Hologic QDR- 2000 densitometers and one Hologic QDR-1000/W (Hologic Inc, Waltham, MA). Short-term precision of bone mineral density measurement was less than 0.5% for spine phantoms (n= 10 for each centre, mean intrasite coefficient of variation [CV] 0.39{+-}0.09% [SD]) and for hip phantoms (n=10 for each centre, mean intrasite coefficient of variation [CV] 0.34{+-}0.10% [SD]). Between-centre measurement (n=10 for each phantom) of a single spine phantom and a single hip phantom (specified mineral contents - 58.5 g and 38.6 g, respectively) revealed ranges of bone mineral content of 57.7-58.1 g (all-point CV=0.52%) and 37.1-37.8 g (all-point CV=0.70%), respectively. When results from pairs of machines were compared there were statistically different mean BMD results for the majority of the ten possible pairings for both spine and hip measurements. Each study centre measured in vitro stability of phantom BMD measurements over a one year period (n=45-283, median 157 for spine; and n=0-262, median 38, for hip); CVs ranged from 0.38 % to 0.53% for the spine measurements and from 0.38 % to 0.54% for the hip measurements. The mean all-point accuracy of the spine phantom measurements was 99.1% and the hip phantom measurements was 96.7%. It is concluded that across a number of instruments assessed in this study, DXA demonstrates in vitro all-point precision of 0.5% for the spine phantom and 0.7% for the hip phantom. The instrument demonstrates accuracy of greater than 99% at the spine and 96% at the hip (authors). 14 refs., 3 tabs., 4 figs.}
journal = []
issue = {5}
volume = {27}
journal type = {AC}
place = {Australia}
year = {1997}
month = {Oct}
}