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Evidence for a decreased susceptibility to acute radiation lethality in young lambs

Journal Article:

Abstract

The survival of 2- to 4-day old Romney-lambs was studied following bilateral /sup 60/Co irradiation at about 3.5 R/min (the exposure rate in air at the mid-line of the animal). Probit analysis of the data yielded an LDsub(50/60) of 900 R with 95% confidence limits of 700-1150 R. Mature sheep irradiated under similar conditions are known to have an LDsub(50/60) in the region of 250-350 R. These data indicate that very young lambs were less susceptible to radiation-induced hemopoietic failure than adults. Dorset Horn lambs and Romneys born by caesarian section also exhibited low susceptibility when irradiated at 2-4 days of age. There are few data available on LD/sub 50/ values for very young, large mammals (as opposed to rodents). Consideration must be given to the possibility that large mammals may be less sensitive to radiation-induced lethality shortly after birth than they are at maturity. Further work on the radiation response as a function of age after birth seems warranted and suggestions for some of the parameters which require investigation are made.
Authors:
Roberts, P B; [1]  Pfeffer, A T [2] 
  1. Department of Scientific and Industrial Research, Lower Hutt (New Zealand). Inst. of Nuclear Sciences
  2. Ministry of Agriculture and Fisheries, Upper Hutt (New Zealand). Wallaceville Animal Research Centre
Publication Date:
Aug 01, 1980
Product Type:
Journal Article
Reference Number:
AIX-12-581362; EDB-81-100935
Resource Relation:
Journal Name: Health Phys.; (United Kingdom); Journal Volume: 39:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; RADIOSENSITIVITY; AGE DEPENDENCE; SHEEP; BLOOD FORMATION; DOSE RATES; GAMMA RADIATION; LETHAL RADIATION DOSE; NEONATES; SURVIVAL CURVES; ANIMALS; DOMESTIC ANIMALS; DOSES; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; LETHAL DOSES; MAMMALS; RADIATION DOSES; RADIATIONS; RUMINANTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
6150471
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: HLTPA
Submitting Site:
INIS
Size:
Pages: 225-229
Announcement Date:
Feb 01, 1981

Journal Article:

Citation Formats

Roberts, P B, and Pfeffer, A T. Evidence for a decreased susceptibility to acute radiation lethality in young lambs. United Kingdom: N. p., 1980. Web.
Roberts, P B, & Pfeffer, A T. Evidence for a decreased susceptibility to acute radiation lethality in young lambs. United Kingdom.
Roberts, P B, and Pfeffer, A T. 1980. "Evidence for a decreased susceptibility to acute radiation lethality in young lambs." United Kingdom.
@misc{etde_6150471,
title = {Evidence for a decreased susceptibility to acute radiation lethality in young lambs}
author = {Roberts, P B, and Pfeffer, A T}
abstractNote = {The survival of 2- to 4-day old Romney-lambs was studied following bilateral /sup 60/Co irradiation at about 3.5 R/min (the exposure rate in air at the mid-line of the animal). Probit analysis of the data yielded an LDsub(50/60) of 900 R with 95% confidence limits of 700-1150 R. Mature sheep irradiated under similar conditions are known to have an LDsub(50/60) in the region of 250-350 R. These data indicate that very young lambs were less susceptible to radiation-induced hemopoietic failure than adults. Dorset Horn lambs and Romneys born by caesarian section also exhibited low susceptibility when irradiated at 2-4 days of age. There are few data available on LD/sub 50/ values for very young, large mammals (as opposed to rodents). Consideration must be given to the possibility that large mammals may be less sensitive to radiation-induced lethality shortly after birth than they are at maturity. Further work on the radiation response as a function of age after birth seems warranted and suggestions for some of the parameters which require investigation are made.}
journal = {Health Phys.; (United Kingdom)}
volume = {39:2}
journal type = {AC}
place = {United Kingdom}
year = {1980}
month = {Aug}
}