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Randomised clinical trial of Levonantradol and Chlorpromazine in the prevention of radiotherapy-induced vomiting

Journal Article:

Abstract

Levonantradol is a cannabis derivative. Cannabinoid anti-emetics are being assessed in cancer chemotherapy but have been little used in radiotherapy to date. A pilot study and randomised trial compared the anti-emetic effect of a standard drug (Chlorpromazine 25 mg) with Levonantradol at two doses (0.5 and 0.75 mg) in patients receiving palliative single fraction radiotherapy to sites likely to cause nausea and vomiting. Most patients were out-patients. Both drugs were well tolerated. The frequency of vomiting was similar in all three groups in both the pilot study and randomised trial.
Authors:
Lucraft, H H; Palmer, M K [1] 
  1. Christie Hospital and Holt Radium Inst., Manchester (UK)
Publication Date:
Nov 01, 1982
Product Type:
Journal Article
Reference Number:
AIX-14-764230; EDB-83-125744
Resource Relation:
Journal Name: Clin. Radiol.; (United Kingdom); Journal Volume: 33:6
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; NAUSEA; CHEMOTHERAPY; RADIOTHERAPY; CHLORPROMAZINE; COMPARATIVE EVALUATIONS; RESPONSE MODIFYING FACTORS; AMINES; AZINES; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DRUGS; HETEROCYCLIC COMPOUNDS; HYPNOTICS AND SEDATIVES; MEDICINE; NUCLEAR MEDICINE; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PHENOTHIAZINES; PSYCHOTROPIC DRUGS; RADIOLOGY; SYMPTOMS; THERAPY; TRANQUILIZERS; 550603* - Medicine- External Radiation in Therapy- (1980-)
OSTI ID:
6146729
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CLRAA
Submitting Site:
HEDB
Size:
Pages: 621-622
Announcement Date:
Jun 01, 1983

Journal Article:

Citation Formats

Lucraft, H H, and Palmer, M K. Randomised clinical trial of Levonantradol and Chlorpromazine in the prevention of radiotherapy-induced vomiting. United Kingdom: N. p., 1982. Web.
Lucraft, H H, & Palmer, M K. Randomised clinical trial of Levonantradol and Chlorpromazine in the prevention of radiotherapy-induced vomiting. United Kingdom.
Lucraft, H H, and Palmer, M K. 1982. "Randomised clinical trial of Levonantradol and Chlorpromazine in the prevention of radiotherapy-induced vomiting." United Kingdom.
@misc{etde_6146729,
title = {Randomised clinical trial of Levonantradol and Chlorpromazine in the prevention of radiotherapy-induced vomiting}
author = {Lucraft, H H, and Palmer, M K}
abstractNote = {Levonantradol is a cannabis derivative. Cannabinoid anti-emetics are being assessed in cancer chemotherapy but have been little used in radiotherapy to date. A pilot study and randomised trial compared the anti-emetic effect of a standard drug (Chlorpromazine 25 mg) with Levonantradol at two doses (0.5 and 0.75 mg) in patients receiving palliative single fraction radiotherapy to sites likely to cause nausea and vomiting. Most patients were out-patients. Both drugs were well tolerated. The frequency of vomiting was similar in all three groups in both the pilot study and randomised trial.}
journal = {Clin. Radiol.; (United Kingdom)}
volume = {33:6}
journal type = {AC}
place = {United Kingdom}
year = {1982}
month = {Nov}
}