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Determination of congenital hypothyroidism in neonatal by immunoradiometric assays of thyrotropin; Determinacion de hipotiroidismo congenito en neonatos por analisis inmunoradiometrico de tirotrofina

Abstract

The congenital hypothyroidism is the endocrine illness more frequent of the childhood, it is the one that produce the devastating effects on the growth and the development. It represent one of the few causes of mental delay that it could be prevented if it is diagnosed and treaty on time. The infants affected with congenital hypothyroidism, could be detected for the apparent presence of some physical abnormalities, which comes the first days of the birth. Unfortunately, in the moment in which the classical manifestations are made present, it is very probable that cerebral damage already exists, for what the affected children should be tried before the three months of life administering them thyroid hormones. In Mexico the incidence of the congenital hypothyroidism is of one for each 1612 births for that is very important in the area of Public Health diagnose in early form and with certainty the congenital hypothyroidism. The TSH hormone or thyrotropin is formed in the hypophysis and intervenes in the synthesis of the thyroid hormones (T3, T4) when the concentration of these is adapted, the formation of TSH is inhibited, for that upon lacking the thyroid hormones the concentration of TSH in the blood is high.  More>>
Authors:
Publication Date:
Jun 01, 1998
Product Type:
Thesis/Dissertation
Report Number:
INIS-MX-068
Reference Number:
SCA: 400703; PA: AIX-29:032346; EDB-98:068453; SN: 98001970755
Resource Relation:
Other Information: TH: Thesis (Pharmaceutical Biologist Chemist).; PBD: 1998
Subject:
40 CHEMISTRY; CHEMICAL PREPARATION; ENDOCRINE DISEASES; IODINE 125; LABELLING; LABORATORY EQUIPMENT; MONOCLONAL ANTIBODIES; RADIOIMMUNOASSAY; REAGENTS; THYROID HORMONES; TSH
OSTI ID:
614627
Research Organizations:
Universidad Michoacana de San Nicolas de Hidalgo. Escuela de Quimicofarmacobiologia. Morelia (Mexico).
Country of Origin:
Mexico
Language:
Spanish
Other Identifying Numbers:
Other: ON: DE98626441; TRN: MX9800064032346
Availability:
INIS; OSTI as DE98626441
Submitting Site:
INIS
Size:
81 p.
Announcement Date:
Jun 26, 1998

Citation Formats

Contreras P, E. Determination of congenital hypothyroidism in neonatal by immunoradiometric assays of thyrotropin; Determinacion de hipotiroidismo congenito en neonatos por analisis inmunoradiometrico de tirotrofina. Mexico: N. p., 1998. Web.
Contreras P, E. Determination of congenital hypothyroidism in neonatal by immunoradiometric assays of thyrotropin; Determinacion de hipotiroidismo congenito en neonatos por analisis inmunoradiometrico de tirotrofina. Mexico.
Contreras P, E. 1998. "Determination of congenital hypothyroidism in neonatal by immunoradiometric assays of thyrotropin; Determinacion de hipotiroidismo congenito en neonatos por analisis inmunoradiometrico de tirotrofina." Mexico.
@misc{etde_614627,
title = {Determination of congenital hypothyroidism in neonatal by immunoradiometric assays of thyrotropin; Determinacion de hipotiroidismo congenito en neonatos por analisis inmunoradiometrico de tirotrofina}
author = {Contreras P, E}
abstractNote = {The congenital hypothyroidism is the endocrine illness more frequent of the childhood, it is the one that produce the devastating effects on the growth and the development. It represent one of the few causes of mental delay that it could be prevented if it is diagnosed and treaty on time. The infants affected with congenital hypothyroidism, could be detected for the apparent presence of some physical abnormalities, which comes the first days of the birth. Unfortunately, in the moment in which the classical manifestations are made present, it is very probable that cerebral damage already exists, for what the affected children should be tried before the three months of life administering them thyroid hormones. In Mexico the incidence of the congenital hypothyroidism is of one for each 1612 births for that is very important in the area of Public Health diagnose in early form and with certainty the congenital hypothyroidism. The TSH hormone or thyrotropin is formed in the hypophysis and intervenes in the synthesis of the thyroid hormones (T3, T4) when the concentration of these is adapted, the formation of TSH is inhibited, for that upon lacking the thyroid hormones the concentration of TSH in the blood is high. For these reasons the shot metabolic state of a newborn could be determined, quantifying the TSH in blood obtained by heel stab of the neonatal, or in coming blood from the umbilical cord, after 48 hours of being born. However because the TSH is similar to other hormones and is in extremely low concentrations, it is made necessary appeal analytic techniques of very sensitive and specific laboratory like the Immunoradiometric assays (Irma) in order to could determine the levels of this hormone in the blood. (Author).}
place = {Mexico}
year = {1998}
month = {Jun}
}