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Radiomodifying effect of hyperglycemia: correlation between a glucose dose and a tumor size. Radiomodifitsiruyushchij ehffekt giperglikemii: zavisimost' ot dozy glyukozy i ob''ema opukholi

Abstract

Experiments were made on rats with trasplantable sarcoma-45 and sarcoma M-1. Dose correlation was established during a study of hyperglycemic radiomodifying action. Glucose injection at a dose of 6-17.5 g/kg was shown to enhance irradiation action. Glucose injection below or above these doses might cause worse radiotherapy results or even the death of animals. The best effect was obtained with small-size tumors. Large tumors(over 2 cm{sup 3}) were less sensitive to hyperglycemia combined with irradiation. Skin radioprotective action of hyperglycemia before irradiation increased with an increase in a dose.
Authors:
Ul'yanenko, S E; Polityukova, N A [1] 
  1. Akademiya Meditsinskikh Nauk SSSR, Obninsk (USSR). Nauchno-Issledovatel'skij Inst. Meditsinskoj Radiologii
Publication Date:
Jan 01, 1991
Product Type:
Journal Article
Reference Number:
AIX-23-001305; EDB-92-007692
Resource Relation:
Journal Name: Meditsinskaya Radiologiya; (USSR); Journal Volume: 36:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HYPERGLYCEMIA; DOSE-RESPONSE RELATIONSHIPS; SARCOMAS; SIZE; BIOLOGICAL RADIATION EFFECTS; QUANTITY RATIO; RATS; RESPONSE MODIFYING FACTORS; ANIMALS; BIOLOGICAL EFFECTS; DISEASES; MAMMALS; NEOPLASMS; RADIATION EFFECTS; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
6139542
Country of Origin:
USSR
Language:
Russian
Other Identifying Numbers:
Journal ID: ISSN 0025-8334; CODEN: MERAA
Submitting Site:
INIS
Size:
Pages: 21-23
Announcement Date:
Jan 01, 1992

Citation Formats

Ul'yanenko, S E, and Polityukova, N A. Radiomodifying effect of hyperglycemia: correlation between a glucose dose and a tumor size. Radiomodifitsiruyushchij ehffekt giperglikemii: zavisimost' ot dozy glyukozy i ob''ema opukholi. USSR: N. p., 1991. Web.
Ul'yanenko, S E, & Polityukova, N A. Radiomodifying effect of hyperglycemia: correlation between a glucose dose and a tumor size. Radiomodifitsiruyushchij ehffekt giperglikemii: zavisimost' ot dozy glyukozy i ob''ema opukholi. USSR.
Ul'yanenko, S E, and Polityukova, N A. 1991. "Radiomodifying effect of hyperglycemia: correlation between a glucose dose and a tumor size. Radiomodifitsiruyushchij ehffekt giperglikemii: zavisimost' ot dozy glyukozy i ob''ema opukholi." USSR.
@misc{etde_6139542,
title = {Radiomodifying effect of hyperglycemia: correlation between a glucose dose and a tumor size. Radiomodifitsiruyushchij ehffekt giperglikemii: zavisimost' ot dozy glyukozy i ob''ema opukholi}
author = {Ul'yanenko, S E, and Polityukova, N A}
abstractNote = {Experiments were made on rats with trasplantable sarcoma-45 and sarcoma M-1. Dose correlation was established during a study of hyperglycemic radiomodifying action. Glucose injection at a dose of 6-17.5 g/kg was shown to enhance irradiation action. Glucose injection below or above these doses might cause worse radiotherapy results or even the death of animals. The best effect was obtained with small-size tumors. Large tumors(over 2 cm{sup 3}) were less sensitive to hyperglycemia combined with irradiation. Skin radioprotective action of hyperglycemia before irradiation increased with an increase in a dose.}
journal = []
volume = {36:1}
journal type = {AC}
place = {USSR}
year = {1991}
month = {Jan}
}