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A first order approximation of the tumor absorbed dose prior to treatment with Sr-89

Abstract

A new technique developed for the estimation of the absorbed dose prior to treatment with Sr-89 is presented. This technique implies that patient undergoes bone scanning with Tc-99m-MDP, two days before the administration of Sr-89. A number of sequential quantitative images are to be obtained over the first 8 hours after the Tc-99m-MDP injection and data are used to derive St-89 time retention curve. For the development of this technique a simplified model for the kinetics of both Sr-89 and Tc-99m-MDP was assumed. Data on the time retention of the two radiopharmaceuticals for a compartment including bone surface and bone space of trabecular and cortical bone for normal adults were combined together. A linear relationship was derived between the time required for the same percentage uptake of the two radiopharmaceuticals after single injection. The absorbed dose in the principal metastases and normal bone, of the same type and volume with the metastases, for two patients who were treated with Sr-89 for metastasized prostatic carcinoma are reported. (authors). 23 refs,3 figs, 2 tabs.
Authors:
Manetou, A; [1]  Toubanakis, N; Lyra, M; Lymouris, G [2] 
  1. NIMITS Hospital, Medical Physics Unit, Athens (Greece)
  2. Areteion University Hospital, Radiology Department, Athens (Greece)
Publication Date:
Dec 31, 1994
Product Type:
Conference
Report Number:
INIS-CY-0002; CONF-940530-
Reference Number:
SCA: 550604; PA: AIX-29:030538; EDB-98:063187; SN: 98001967878
Resource Relation:
Conference: MPBE `94: 1. international conference on medical physics and biomedical engineering, Nicosia (Cyprus), 3-7 May 1994; Other Information: DN: 23 refs,3 figs, 2 tabs.; PBD: 1994; Related Information: Is Part Of Proceedings of the international conference on medical physics and biomedical engineering (MPBE `94). Vol. 2; Spyrou, S.; Christofides, S.; Pattichis, C.S.; Keravnou, E.; Schizas, C.N.; Christodoulides, G. [eds.]; PB: 311 p.
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; RADIATION DOSES; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; RADIOTHERAPY; SCINTISCANNING; STRONTIUM 89
OSTI ID:
612714
Research Organizations:
Cyprus Association of Medical Physics and Biomedical Engineering (CAMPBE), Nicosia (Cyprus); Cyprus Univ., Nicosia (Cyprus). Dept. of Computer Science.
Country of Origin:
Cyprus
Language:
English
Other Identifying Numbers:
Other: ON: DE98625476; ISBN 9963-607-05-5; TRN: CY9800012030538
Availability:
INIS; OSTI as DE98625476
Submitting Site:
INIS
Size:
pp. 566-574
Announcement Date:

Citation Formats

Manetou, A, Toubanakis, N, Lyra, M, and Lymouris, G. A first order approximation of the tumor absorbed dose prior to treatment with Sr-89. Cyprus: N. p., 1994. Web.
Manetou, A, Toubanakis, N, Lyra, M, & Lymouris, G. A first order approximation of the tumor absorbed dose prior to treatment with Sr-89. Cyprus.
Manetou, A, Toubanakis, N, Lyra, M, and Lymouris, G. 1994. "A first order approximation of the tumor absorbed dose prior to treatment with Sr-89." Cyprus.
@misc{etde_612714,
title = {A first order approximation of the tumor absorbed dose prior to treatment with Sr-89}
author = {Manetou, A, Toubanakis, N, Lyra, M, and Lymouris, G}
abstractNote = {A new technique developed for the estimation of the absorbed dose prior to treatment with Sr-89 is presented. This technique implies that patient undergoes bone scanning with Tc-99m-MDP, two days before the administration of Sr-89. A number of sequential quantitative images are to be obtained over the first 8 hours after the Tc-99m-MDP injection and data are used to derive St-89 time retention curve. For the development of this technique a simplified model for the kinetics of both Sr-89 and Tc-99m-MDP was assumed. Data on the time retention of the two radiopharmaceuticals for a compartment including bone surface and bone space of trabecular and cortical bone for normal adults were combined together. A linear relationship was derived between the time required for the same percentage uptake of the two radiopharmaceuticals after single injection. The absorbed dose in the principal metastases and normal bone, of the same type and volume with the metastases, for two patients who were treated with Sr-89 for metastasized prostatic carcinoma are reported. (authors). 23 refs,3 figs, 2 tabs.}
place = {Cyprus}
year = {1994}
month = {Dec}
}