You need JavaScript to view this

Early x-irradiation of rats. Part 2. Effect of granule cells and their dendrodendritic synapses in the olfactory bulb

Abstract

Low, repeated doses of X-rays from a Co/sup 60/ source were used to impair the development of the granule cells and their dendritic terminals in the olfactory bulb, and the resulting effect was studied under light and electron microscopes at 9 days of age. Irradiation of rats from embryonic day 18 (in utero) to postnatal day 5 resulted, among others, in maldevelopment of the (internal) granule cell and external plexiform layers. This was accompanied by a decrease in the number and the density of the granule cells, and the remaining granule cells contained less ribosomes, regardless of their position within the layer. This implies that both supposed subtypes of granule cells were effected. In the external plexiform layer, a reduced number of mature dendrodendritic synapses and signs of harmed granule gemmules were observed. The results suggest that intrauterinal plus postnatal irradiation with low, repeated doses of X-rays may be an effective tool impairing the development of prenatally forming neurons.
Authors:
Publication Date:
Jan 01, 1987
Product Type:
Journal Article
Reference Number:
EDB-87-159510
Resource Relation:
Journal Name: Neuroscience; (United Kingdom); Journal Volume: 20:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; NERVE CELLS; BIOLOGICAL RADIATION EFFECTS; OLFACTORY BULBS; CHRONIC IRRADIATION; COBALT 60; EXTERNAL IRRADIATION; LOW DOSE IRRADIATION; PERINATAL IRRADIATION; RATS; ULTRASTRUCTURAL CHANGES; X RADIATION; ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; CHRONIC EXPOSURE; COBALT ISOTOPES; ELECTROMAGNETIC RADIATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; MORPHOLOGICAL CHANGES; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RODENTS; SOMATIC CELLS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
6121175
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: NRSCD
Submitting Site:
GBN
Size:
Pages: 709-716
Announcement Date:

Citation Formats

Halasz, N. Early x-irradiation of rats. Part 2. Effect of granule cells and their dendrodendritic synapses in the olfactory bulb. United Kingdom: N. p., 1987. Web. doi:10.1016/0306-4522(87)90121-7.
Halasz, N. Early x-irradiation of rats. Part 2. Effect of granule cells and their dendrodendritic synapses in the olfactory bulb. United Kingdom. doi:10.1016/0306-4522(87)90121-7.
Halasz, N. 1987. "Early x-irradiation of rats. Part 2. Effect of granule cells and their dendrodendritic synapses in the olfactory bulb." United Kingdom. doi:10.1016/0306-4522(87)90121-7. https://www.osti.gov/servlets/purl/10.1016/0306-4522(87)90121-7.
@misc{etde_6121175,
title = {Early x-irradiation of rats. Part 2. Effect of granule cells and their dendrodendritic synapses in the olfactory bulb}
author = {Halasz, N}
abstractNote = {Low, repeated doses of X-rays from a Co/sup 60/ source were used to impair the development of the granule cells and their dendritic terminals in the olfactory bulb, and the resulting effect was studied under light and electron microscopes at 9 days of age. Irradiation of rats from embryonic day 18 (in utero) to postnatal day 5 resulted, among others, in maldevelopment of the (internal) granule cell and external plexiform layers. This was accompanied by a decrease in the number and the density of the granule cells, and the remaining granule cells contained less ribosomes, regardless of their position within the layer. This implies that both supposed subtypes of granule cells were effected. In the external plexiform layer, a reduced number of mature dendrodendritic synapses and signs of harmed granule gemmules were observed. The results suggest that intrauterinal plus postnatal irradiation with low, repeated doses of X-rays may be an effective tool impairing the development of prenatally forming neurons.}
doi = {10.1016/0306-4522(87)90121-7}
journal = {Neuroscience; (United Kingdom)}
volume = {20:2}
journal type = {AC}
place = {United Kingdom}
year = {1987}
month = {Jan}
}