Abstract
Tissue-type plasminogen activator (t-PA) effectively lyses activate thrombus by direct action. Recombinant t-PA (rt-PA) was labeled with technetium-99m ([sup 99m]Tc) to investigate the in vivo binding to fibrin clots in a feline cerebral embolism model created by insertion of an artificial fibrin clot within the carotid artery. [sup 99m]Tc-rt-PA administered intravenously provided clearer imaging of clots after priming with cold rt-PA, with uptake peaking 5-10 minutes after the injection. [sup 99m]Tc-labeled human serum albumin was not retained at clot sites. Systemically administered [sup 99m]Tc-rt-PA binds to fibrin clots within carotid arteries in our feline model. Our results suggest that the interaction of intrinsic plasminogen activator inhibitors with extrinsically administered rt-PA may regulate the demonstration of a clot, although the precise mechanism is unclear. (author).
Takahashi, Akihiro;
Itoh, Kazuo;
Tsukamoto, Eriko;
Furudate, Masayori;
Kamiyama, Hiroyasu;
Abe, Hiroshi
[1]
- Hokkaido Univ., Sapporo (Japan). School of Medicine
Citation Formats
Takahashi, Akihiro, Itoh, Kazuo, Tsukamoto, Eriko, Furudate, Masayori, Kamiyama, Hiroyasu, and Abe, Hiroshi.
Technetium-99m-labeled recombinant tissue plasminogen activator for the imaging of emboli in vivo.
Japan: N. p.,
1993.
Web.
Takahashi, Akihiro, Itoh, Kazuo, Tsukamoto, Eriko, Furudate, Masayori, Kamiyama, Hiroyasu, & Abe, Hiroshi.
Technetium-99m-labeled recombinant tissue plasminogen activator for the imaging of emboli in vivo.
Japan.
Takahashi, Akihiro, Itoh, Kazuo, Tsukamoto, Eriko, Furudate, Masayori, Kamiyama, Hiroyasu, and Abe, Hiroshi.
1993.
"Technetium-99m-labeled recombinant tissue plasminogen activator for the imaging of emboli in vivo."
Japan.
@misc{etde_6117904,
title = {Technetium-99m-labeled recombinant tissue plasminogen activator for the imaging of emboli in vivo}
author = {Takahashi, Akihiro, Itoh, Kazuo, Tsukamoto, Eriko, Furudate, Masayori, Kamiyama, Hiroyasu, and Abe, Hiroshi}
abstractNote = {Tissue-type plasminogen activator (t-PA) effectively lyses activate thrombus by direct action. Recombinant t-PA (rt-PA) was labeled with technetium-99m ([sup 99m]Tc) to investigate the in vivo binding to fibrin clots in a feline cerebral embolism model created by insertion of an artificial fibrin clot within the carotid artery. [sup 99m]Tc-rt-PA administered intravenously provided clearer imaging of clots after priming with cold rt-PA, with uptake peaking 5-10 minutes after the injection. [sup 99m]Tc-labeled human serum albumin was not retained at clot sites. Systemically administered [sup 99m]Tc-rt-PA binds to fibrin clots within carotid arteries in our feline model. Our results suggest that the interaction of intrinsic plasminogen activator inhibitors with extrinsically administered rt-PA may regulate the demonstration of a clot, although the precise mechanism is unclear. (author).}
journal = []
volume = {33:7}
journal type = {AC}
place = {Japan}
year = {1993}
month = {Jul}
}
title = {Technetium-99m-labeled recombinant tissue plasminogen activator for the imaging of emboli in vivo}
author = {Takahashi, Akihiro, Itoh, Kazuo, Tsukamoto, Eriko, Furudate, Masayori, Kamiyama, Hiroyasu, and Abe, Hiroshi}
abstractNote = {Tissue-type plasminogen activator (t-PA) effectively lyses activate thrombus by direct action. Recombinant t-PA (rt-PA) was labeled with technetium-99m ([sup 99m]Tc) to investigate the in vivo binding to fibrin clots in a feline cerebral embolism model created by insertion of an artificial fibrin clot within the carotid artery. [sup 99m]Tc-rt-PA administered intravenously provided clearer imaging of clots after priming with cold rt-PA, with uptake peaking 5-10 minutes after the injection. [sup 99m]Tc-labeled human serum albumin was not retained at clot sites. Systemically administered [sup 99m]Tc-rt-PA binds to fibrin clots within carotid arteries in our feline model. Our results suggest that the interaction of intrinsic plasminogen activator inhibitors with extrinsically administered rt-PA may regulate the demonstration of a clot, although the precise mechanism is unclear. (author).}
journal = []
volume = {33:7}
journal type = {AC}
place = {Japan}
year = {1993}
month = {Jul}
}