You need JavaScript to view this

Generation of volatile hydrocarbons as a measure of radiation-induced lipid peroxidation in vitro

Journal Article:

Abstract

Using gas chromatography techniques, pentane production from microsomes could be detected at gamma radiation doses as low as 50 Gy, but definite increases were observed only with the addition of the peroxidation promoter ADP-Fe. There was a small but linear increase in pentane production, and presumably lipid peroxidation, when nonirradiated microsomes alone were incubated. The addition of ADP-Fe induced a further production of pentane which was linear with incubation time. Radiation alone (700 and 2000 Gy) also induced pentane production, but the highest levels were observed with the combination of ADP-Fe and radiation. In microsomes irradiated with 700 Gy, the rate of pentane production was greatest during the first 100 min post-irradiation. In comparing radiation-induced pentane generation to the enzymatic-induced system, it was seen that pentane production was much greater in the latter system.
Authors:
Dobbs, C R; Kumar, K S; Weiss, J F; Catravas, G N [1] 
  1. Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
Publication Date:
Apr 01, 1981
Product Type:
Journal Article
Reference Number:
AIX-12-615898; EDB-81-131975
Resource Relation:
Journal Name: Int. J. Radiat. Biol. Relat. Stud. Phys., Chem. Med.; (United Kingdom); Journal Volume: 39:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LIPIDS; BIOLOGICAL RADIATION EFFECTS; MICROSOMES; ADP; DOSE-RESPONSE RELATIONSHIPS; GAMMA RADIATION; IN VITRO; IRON CHLORIDES; OXIDATION; PENTANE; PEROXIDES; RESPONSE MODIFYING FACTORS; TIME DEPENDENCE; ALKANES; BIOLOGICAL EFFECTS; CELL CONSTITUENTS; CHEMICAL REACTIONS; CHLORIDES; CHLORINE COMPOUNDS; ELECTROMAGNETIC RADIATION; HALIDES; HALOGEN COMPOUNDS; HYDROCARBONS; IONIZING RADIATIONS; IRON COMPOUNDS; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANOIDS; OXYGEN COMPOUNDS; RADIATION EFFECTS; RADIATIONS; TRANSITION ELEMENT COMPOUNDS; 560121* - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
6114851
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: IJRBA
Submitting Site:
INIS
Size:
Pages: 445-449
Announcement Date:
Aug 01, 1981

Journal Article:

Citation Formats

Dobbs, C R, Kumar, K S, Weiss, J F, and Catravas, G N. Generation of volatile hydrocarbons as a measure of radiation-induced lipid peroxidation in vitro. United Kingdom: N. p., 1981. Web.
Dobbs, C R, Kumar, K S, Weiss, J F, & Catravas, G N. Generation of volatile hydrocarbons as a measure of radiation-induced lipid peroxidation in vitro. United Kingdom.
Dobbs, C R, Kumar, K S, Weiss, J F, and Catravas, G N. 1981. "Generation of volatile hydrocarbons as a measure of radiation-induced lipid peroxidation in vitro." United Kingdom.
@misc{etde_6114851,
title = {Generation of volatile hydrocarbons as a measure of radiation-induced lipid peroxidation in vitro}
author = {Dobbs, C R, Kumar, K S, Weiss, J F, and Catravas, G N}
abstractNote = {Using gas chromatography techniques, pentane production from microsomes could be detected at gamma radiation doses as low as 50 Gy, but definite increases were observed only with the addition of the peroxidation promoter ADP-Fe. There was a small but linear increase in pentane production, and presumably lipid peroxidation, when nonirradiated microsomes alone were incubated. The addition of ADP-Fe induced a further production of pentane which was linear with incubation time. Radiation alone (700 and 2000 Gy) also induced pentane production, but the highest levels were observed with the combination of ADP-Fe and radiation. In microsomes irradiated with 700 Gy, the rate of pentane production was greatest during the first 100 min post-irradiation. In comparing radiation-induced pentane generation to the enzymatic-induced system, it was seen that pentane production was much greater in the latter system.}
journal = {Int. J. Radiat. Biol. Relat. Stud. Phys., Chem. Med.; (United Kingdom)}
volume = {39:4}
journal type = {AC}
place = {United Kingdom}
year = {1981}
month = {Apr}
}