Abstract
An in vitro method for detecting IgE insulin antibody using the principle of the radioallergosorbent test (RAST) is described. In six patients with insulin allergy, the RAST values were higher than in normal persons or insulin-treated diabetics without insulin allergy. No differences were observed between normal persons and insulin-treated diabetics without insulin allergy. Moreover, it was observed that in one patient treated with highly purified insulin, there was a gradual decrease of RAST value parallel to the radioinsulin binding activity and clinical allergic symptoms. The RAST value of insulin is slightly inhibited by non-IgE antibodies and is, therefore, a semiquantitative value. However, the RAST is simple to perform and reproducible; it is therefore very useful in the detection of IgE insulin antibodies.
Nakagawa, S;
Nakayama, H;
Sasaki, T;
Watanabe, T;
Aoki, S;
[1]
Saito, N
[2]
- Hokkaido Univ., Sapporo (Japan). 2. Dept. of Medicine
- Sapporo Railway Hospital (Japan). Dept. of Medicine
Citation Formats
Nakagawa, S, Nakayama, H, Sasaki, T, Watanabe, T, Aoki, S, and Saito, N.
Detection of IgE insulin antibody with radioallergosorbent test.
Germany: N. p.,
1978.
Web.
Nakagawa, S, Nakayama, H, Sasaki, T, Watanabe, T, Aoki, S, & Saito, N.
Detection of IgE insulin antibody with radioallergosorbent test.
Germany.
Nakagawa, S, Nakayama, H, Sasaki, T, Watanabe, T, Aoki, S, and Saito, N.
1978.
"Detection of IgE insulin antibody with radioallergosorbent test."
Germany.
@misc{etde_6100944,
title = {Detection of IgE insulin antibody with radioallergosorbent test}
author = {Nakagawa, S, Nakayama, H, Sasaki, T, Watanabe, T, Aoki, S, and Saito, N}
abstractNote = {An in vitro method for detecting IgE insulin antibody using the principle of the radioallergosorbent test (RAST) is described. In six patients with insulin allergy, the RAST values were higher than in normal persons or insulin-treated diabetics without insulin allergy. No differences were observed between normal persons and insulin-treated diabetics without insulin allergy. Moreover, it was observed that in one patient treated with highly purified insulin, there was a gradual decrease of RAST value parallel to the radioinsulin binding activity and clinical allergic symptoms. The RAST value of insulin is slightly inhibited by non-IgE antibodies and is, therefore, a semiquantitative value. However, the RAST is simple to perform and reproducible; it is therefore very useful in the detection of IgE insulin antibodies.}
journal = []
volume = {14:1}
journal type = {AC}
place = {Germany}
year = {1978}
month = {Jan}
}
title = {Detection of IgE insulin antibody with radioallergosorbent test}
author = {Nakagawa, S, Nakayama, H, Sasaki, T, Watanabe, T, Aoki, S, and Saito, N}
abstractNote = {An in vitro method for detecting IgE insulin antibody using the principle of the radioallergosorbent test (RAST) is described. In six patients with insulin allergy, the RAST values were higher than in normal persons or insulin-treated diabetics without insulin allergy. No differences were observed between normal persons and insulin-treated diabetics without insulin allergy. Moreover, it was observed that in one patient treated with highly purified insulin, there was a gradual decrease of RAST value parallel to the radioinsulin binding activity and clinical allergic symptoms. The RAST value of insulin is slightly inhibited by non-IgE antibodies and is, therefore, a semiquantitative value. However, the RAST is simple to perform and reproducible; it is therefore very useful in the detection of IgE insulin antibodies.}
journal = []
volume = {14:1}
journal type = {AC}
place = {Germany}
year = {1978}
month = {Jan}
}