Abstract
We examined the magnetic resonance (MR) image of midbrain and striatum in 30 patients with Parkinson's disease (PD), 10 patients with vascular Parkinsonism (VP) and 10 age-matched control subjects. Studies were performed on a high field strength (1.5 tesla) MRI unit. T2-weighted spin echo pulse sequence (TR 2500 ms/TE 40 ms) was used. Intensity profiles of a straight line perpendicular to the pars compacta through the center of the red nucleus were made on an image of the midbrain. We measured the width of the valley at half-height between the peaks of intensity representing the red nucleus and the crus cerebri-pars reticulata complex and used this as an index of the width of the pars compacta signal. The mean width of the pars compacta signal was 2.7 mm in the PD group and 4.3 mm in controls. The difference between the means was highly significant (p<0.01). While not significant statistically, there was a trend toward narrowing of the width of pars compacta signal of substantia nigra in the PD group as the Yahr's grade or disease duration progressed. In hemiparkinsonism, MRI revealed significant narrowing of the pars compacta signal on the contra-lateral side to the clinical predominant side. The mean
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Aotsuka, Akiyo;
Shinotoh, Hitoshi;
Hirayama, Keizo;
[1]
Ikehira, Hiroo;
Fukuda, Hiroshi
- Chiba Univ. (Japan). School of Medicine
Citation Formats
Aotsuka, Akiyo, Shinotoh, Hitoshi, Hirayama, Keizo, Ikehira, Hiroo, and Fukuda, Hiroshi.
MRI in Parkinson's disease and vascular Parkinsonism; Study on the lesion of substantia nigra.
Japan: N. p.,
1991.
Web.
Aotsuka, Akiyo, Shinotoh, Hitoshi, Hirayama, Keizo, Ikehira, Hiroo, & Fukuda, Hiroshi.
MRI in Parkinson's disease and vascular Parkinsonism; Study on the lesion of substantia nigra.
Japan.
Aotsuka, Akiyo, Shinotoh, Hitoshi, Hirayama, Keizo, Ikehira, Hiroo, and Fukuda, Hiroshi.
1991.
"MRI in Parkinson's disease and vascular Parkinsonism; Study on the lesion of substantia nigra."
Japan.
@misc{etde_6099029,
title = {MRI in Parkinson's disease and vascular Parkinsonism; Study on the lesion of substantia nigra}
author = {Aotsuka, Akiyo, Shinotoh, Hitoshi, Hirayama, Keizo, Ikehira, Hiroo, and Fukuda, Hiroshi}
abstractNote = {We examined the magnetic resonance (MR) image of midbrain and striatum in 30 patients with Parkinson's disease (PD), 10 patients with vascular Parkinsonism (VP) and 10 age-matched control subjects. Studies were performed on a high field strength (1.5 tesla) MRI unit. T2-weighted spin echo pulse sequence (TR 2500 ms/TE 40 ms) was used. Intensity profiles of a straight line perpendicular to the pars compacta through the center of the red nucleus were made on an image of the midbrain. We measured the width of the valley at half-height between the peaks of intensity representing the red nucleus and the crus cerebri-pars reticulata complex and used this as an index of the width of the pars compacta signal. The mean width of the pars compacta signal was 2.7 mm in the PD group and 4.3 mm in controls. The difference between the means was highly significant (p<0.01). While not significant statistically, there was a trend toward narrowing of the width of pars compacta signal of substantia nigra in the PD group as the Yahr's grade or disease duration progressed. In hemiparkinsonism, MRI revealed significant narrowing of the pars compacta signal on the contra-lateral side to the clinical predominant side. The mean width of the pars compacta signal was 3.9 mm in the VP group, but the decrease was not significant. MRI in VP group showed multiple high intensity area in the basal ganglia and the white matter, and periventricular hyperintensity area (PVHIA). There was no statistically significant difference in the frequency of restoration of the signal intensity in the lateral portion of the substantia nigra among PD, VP and control groups. The low signal intensity in the posterolateral putamen was not found in the 3 groups. The narrowing of the pars compacta signal has been attributed either to atrophy of the pars compacta or to increased deposition of iron in this region. The narrowing of the pars compacta signal reflected pathophysiology of PD. (J.P.N.).}
journal = []
volume = {31:6}
journal type = {AC}
place = {Japan}
year = {1991}
month = {Jun}
}
title = {MRI in Parkinson's disease and vascular Parkinsonism; Study on the lesion of substantia nigra}
author = {Aotsuka, Akiyo, Shinotoh, Hitoshi, Hirayama, Keizo, Ikehira, Hiroo, and Fukuda, Hiroshi}
abstractNote = {We examined the magnetic resonance (MR) image of midbrain and striatum in 30 patients with Parkinson's disease (PD), 10 patients with vascular Parkinsonism (VP) and 10 age-matched control subjects. Studies were performed on a high field strength (1.5 tesla) MRI unit. T2-weighted spin echo pulse sequence (TR 2500 ms/TE 40 ms) was used. Intensity profiles of a straight line perpendicular to the pars compacta through the center of the red nucleus were made on an image of the midbrain. We measured the width of the valley at half-height between the peaks of intensity representing the red nucleus and the crus cerebri-pars reticulata complex and used this as an index of the width of the pars compacta signal. The mean width of the pars compacta signal was 2.7 mm in the PD group and 4.3 mm in controls. The difference between the means was highly significant (p<0.01). While not significant statistically, there was a trend toward narrowing of the width of pars compacta signal of substantia nigra in the PD group as the Yahr's grade or disease duration progressed. In hemiparkinsonism, MRI revealed significant narrowing of the pars compacta signal on the contra-lateral side to the clinical predominant side. The mean width of the pars compacta signal was 3.9 mm in the VP group, but the decrease was not significant. MRI in VP group showed multiple high intensity area in the basal ganglia and the white matter, and periventricular hyperintensity area (PVHIA). There was no statistically significant difference in the frequency of restoration of the signal intensity in the lateral portion of the substantia nigra among PD, VP and control groups. The low signal intensity in the posterolateral putamen was not found in the 3 groups. The narrowing of the pars compacta signal has been attributed either to atrophy of the pars compacta or to increased deposition of iron in this region. The narrowing of the pars compacta signal reflected pathophysiology of PD. (J.P.N.).}
journal = []
volume = {31:6}
journal type = {AC}
place = {Japan}
year = {1991}
month = {Jun}
}