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Organolead compounds shown to be genetically active

Journal Article:

Abstract

The purpose of the present investigation was to determine whether alkyllead compounds would cause a genetic effect similar to that caused by alkyl mercury compounds. Experiments were conducted on Allium cepa (onion) in order to determine the effect of lead compounds on the spindle fiber mechanism. Results indicate that disturbances of the spindle fiber mechanism occur even at very low concentrations. The lowest concentration at which such effects are observed seems to be between 10/sup -6/ and 10/sup -7/ M for the organic compounds. Although no effect can be observed on the spindle fibers at lower dosages, the mitotic index is changed even at a dose of 10/sup -7/ M with dimethyllead. A preliminary experiment was made on Drosophila with triethyllead in order to investigate whether the effects which were observed on mitoses in Allium would also be observed in a meiotic cell system in an animal.
Publication Date:
Jan 01, 1972
Product Type:
Journal Article
Reference Number:
EDB-85-049444
Resource Relation:
Journal Name: Ambio; (Norway); Journal Volume: 1:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ALLIUM CEPA; ULTRASTRUCTURAL CHANGES; DROSOPHILA; LEAD; GENETIC EFFECTS; CELL CONSTITUENTS; CYTOLOGY; DOSE-RESPONSE RELATIONSHIPS; GENETICS; MITOSIS; ANIMALS; ARTHROPODS; BIOLOGICAL EFFECTS; BIOLOGY; CELL DIVISION; DIPTERA; ELEMENTS; FLIES; FRUIT FLIES; INSECTS; INVERTEBRATES; METALS; MORPHOLOGICAL CHANGES; PLANTS; 560303* - Chemicals Metabolism & Toxicology- Plants- (-1987); 560304 - Chemicals Metabolism & Toxicology- Invertebrates- (-1987)
OSTI ID:
6097561
Research Organizations:
Univ. of Stockholm, Sweden
Country of Origin:
Norway
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: AMBOC
Submitting Site:
HEDB
Size:
Pages: 29-31
Announcement Date:

Journal Article:

Citation Formats

Ahlberg, J, Ramel, C, and Wachtmeister, C A. Organolead compounds shown to be genetically active. Norway: N. p., 1972. Web.
Ahlberg, J, Ramel, C, & Wachtmeister, C A. Organolead compounds shown to be genetically active. Norway.
Ahlberg, J, Ramel, C, and Wachtmeister, C A. 1972. "Organolead compounds shown to be genetically active." Norway.
@misc{etde_6097561,
title = {Organolead compounds shown to be genetically active}
author = {Ahlberg, J, Ramel, C, and Wachtmeister, C A}
abstractNote = {The purpose of the present investigation was to determine whether alkyllead compounds would cause a genetic effect similar to that caused by alkyl mercury compounds. Experiments were conducted on Allium cepa (onion) in order to determine the effect of lead compounds on the spindle fiber mechanism. Results indicate that disturbances of the spindle fiber mechanism occur even at very low concentrations. The lowest concentration at which such effects are observed seems to be between 10/sup -6/ and 10/sup -7/ M for the organic compounds. Although no effect can be observed on the spindle fibers at lower dosages, the mitotic index is changed even at a dose of 10/sup -7/ M with dimethyllead. A preliminary experiment was made on Drosophila with triethyllead in order to investigate whether the effects which were observed on mitoses in Allium would also be observed in a meiotic cell system in an animal.}
journal = {Ambio; (Norway)}
volume = {1:1}
journal type = {AC}
place = {Norway}
year = {1972}
month = {Jan}
}