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Development of chronic myelocytic leukemia in atomic bomb survivors

Journal Article:

Abstract

On the basis of the evaluation of laboratory findings in 102 cases including 20 cases which were diagnosed as very early stage chronic myelogenic leukemia (CML), chronological orders of the histopathological pictures of CML were shown as follows; myeloid occupation with Ph/sup 1/-positive cells (leucocyte count 10/sup 10//L)--basophilic leucocytosis thrombocytosis and low activity of neutrocyte-AP (1 - 2 x 10/sup 10//L)--appearance of immature granulocytes more than 5% in the peripheral blood (2 x 10/sup 10//L)--increase of serum Vit. B/sub 12/ (2.5 x 10/sup 10//L)--splenomegaly (5 x 10/sup 10//L)--appearance of subjective symptoms (7 x 10/sup 10//L or more). The relation between an actual number of Ph/sup 1/-positive cells and time of their appearance (months) can be expressed as log Y = 0.053 + 10.023. It was estimated that it takes about 8 years since one Ph/sup 1/-positive cell appears in the body until the leucocyte count becomes 10/sup 11//L and the patient consult a doctor. The idea that Ph/sup 1/-positive cells can be transformed to more malignant clones is helpful to understand the pathological feature of acute transformation of CML.
Authors:
Kamada, N; Oguma, N; Tanaka, R; Kuramoto, A; Ohkita, T [1] 
  1. Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology
Publication Date:
Apr 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-10-426296; EDB-79-107407
Resource Relation:
Journal Name: Hiroshima Igaku; (Japan); Journal Volume: 31:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; A-BOMB SURVIVORS; DELAYED RADIATION EFFECTS; EPIDEMIOLOGY; EOSINOPHILS; HIROSHIMA; MYELOID LEUKEMIA; NEUTROPHILS; PATHOLOGY; PHILADELPHIA CHROMOSOME; SPLEEN; ASIA; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CHROMOSOMES; DISEASES; HEMIC DISEASES; JAPAN; LEUKEMIA; LEUKOCYTES; NEOPLASMS; ORGANS; RADIATION EFFECTS; 560151* - Radiation Effects on Animals- Man
OSTI ID:
6095998
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: HIRGA
Submitting Site:
INIS
Size:
Pages: 506-511
Announcement Date:
Apr 01, 1979

Journal Article:

Citation Formats

Kamada, N, Oguma, N, Tanaka, R, Kuramoto, A, and Ohkita, T. Development of chronic myelocytic leukemia in atomic bomb survivors. Japan: N. p., 1978. Web.
Kamada, N, Oguma, N, Tanaka, R, Kuramoto, A, & Ohkita, T. Development of chronic myelocytic leukemia in atomic bomb survivors. Japan.
Kamada, N, Oguma, N, Tanaka, R, Kuramoto, A, and Ohkita, T. 1978. "Development of chronic myelocytic leukemia in atomic bomb survivors." Japan.
@misc{etde_6095998,
title = {Development of chronic myelocytic leukemia in atomic bomb survivors}
author = {Kamada, N, Oguma, N, Tanaka, R, Kuramoto, A, and Ohkita, T}
abstractNote = {On the basis of the evaluation of laboratory findings in 102 cases including 20 cases which were diagnosed as very early stage chronic myelogenic leukemia (CML), chronological orders of the histopathological pictures of CML were shown as follows; myeloid occupation with Ph/sup 1/-positive cells (leucocyte count 10/sup 10//L)--basophilic leucocytosis thrombocytosis and low activity of neutrocyte-AP (1 - 2 x 10/sup 10//L)--appearance of immature granulocytes more than 5% in the peripheral blood (2 x 10/sup 10//L)--increase of serum Vit. B/sub 12/ (2.5 x 10/sup 10//L)--splenomegaly (5 x 10/sup 10//L)--appearance of subjective symptoms (7 x 10/sup 10//L or more). The relation between an actual number of Ph/sup 1/-positive cells and time of their appearance (months) can be expressed as log Y = 0.053 + 10.023. It was estimated that it takes about 8 years since one Ph/sup 1/-positive cell appears in the body until the leucocyte count becomes 10/sup 11//L and the patient consult a doctor. The idea that Ph/sup 1/-positive cells can be transformed to more malignant clones is helpful to understand the pathological feature of acute transformation of CML.}
journal = {Hiroshima Igaku; (Japan)}
volume = {31:4}
journal type = {AC}
place = {Japan}
year = {1978}
month = {Apr}
}