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Measurement of intestinal progression of a meal and its residues in normal subjects and patients with functional diarrhoea by a dual isotope technique

Abstract

A new double isotopic method was used to measure the gastrointestinal progression of a meal in nine healthy subjects and seven patients with functional diarrhoea. 51 Chromium chloride (colonic marker) was ingested eight hours before the beginning of the scintigraphic study so that it was by then located in the colon at that time. A second marker, 99m Technetium sulphur colloid labelled the meal. Scintigraphic images were taken before and after the meal for two hours, detecting simultaneously the two isotopes. In the 51Cr window right colon was localised and intracolonic propulsion was studied; and in the 99m Tc window gastric emptying and colon filling of the meal marker was quantified. A propulsive gastrocolic reflex was evidenced in five of the seven patients with functional diarrhoea but in none of the normal subjects. Unabsorbed residues of the meal are propelled rapidly in the ileocaecal region. Small intestinal transit of the meal marker was twice as rapid in patients with functional diarrhoea as in normal subjects.
Authors:
Jian, R; Najean, Y; Bernier, J J; [1]  Hopital Saint-Louis, 75 - Paris (France))
  1. Hopital Saint-Lazare, 75 - Paris (France). Service de Medecine
Publication Date:
Jul 01, 1984
Product Type:
Journal Article
Reference Number:
AIX-16-002388; EDB-85-049014
Resource Relation:
Journal Name: Gut; (United Kingdom); Journal Volume: 25:7
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; GASTROINTESTINAL TRACT; DYNAMIC FUNCTION STUDIES; CHROMIUM 51; DUAL-ISOTOPE SUBTRACTION TECHNIQUE; SCINTISCANNING; TECHNETIUM 99; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHROMIUM ISOTOPES; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM ISOTOPES; TRACER TECHNIQUES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6056997
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: GUTTA
Submitting Site:
HEDB
Size:
Pages: 728-731
Announcement Date:
Dec 01, 1984

Citation Formats

Jian, R, Najean, Y, Bernier, J J, and Hopital Saint-Louis, 75 - Paris (France)). Measurement of intestinal progression of a meal and its residues in normal subjects and patients with functional diarrhoea by a dual isotope technique. United Kingdom: N. p., 1984. Web.
Jian, R, Najean, Y, Bernier, J J, & Hopital Saint-Louis, 75 - Paris (France)). Measurement of intestinal progression of a meal and its residues in normal subjects and patients with functional diarrhoea by a dual isotope technique. United Kingdom.
Jian, R, Najean, Y, Bernier, J J, and Hopital Saint-Louis, 75 - Paris (France)). 1984. "Measurement of intestinal progression of a meal and its residues in normal subjects and patients with functional diarrhoea by a dual isotope technique." United Kingdom.
@misc{etde_6056997,
title = {Measurement of intestinal progression of a meal and its residues in normal subjects and patients with functional diarrhoea by a dual isotope technique}
author = {Jian, R, Najean, Y, Bernier, J J, and Hopital Saint-Louis, 75 - Paris (France))}
abstractNote = {A new double isotopic method was used to measure the gastrointestinal progression of a meal in nine healthy subjects and seven patients with functional diarrhoea. 51 Chromium chloride (colonic marker) was ingested eight hours before the beginning of the scintigraphic study so that it was by then located in the colon at that time. A second marker, 99m Technetium sulphur colloid labelled the meal. Scintigraphic images were taken before and after the meal for two hours, detecting simultaneously the two isotopes. In the 51Cr window right colon was localised and intracolonic propulsion was studied; and in the 99m Tc window gastric emptying and colon filling of the meal marker was quantified. A propulsive gastrocolic reflex was evidenced in five of the seven patients with functional diarrhoea but in none of the normal subjects. Unabsorbed residues of the meal are propelled rapidly in the ileocaecal region. Small intestinal transit of the meal marker was twice as rapid in patients with functional diarrhoea as in normal subjects.}
journal = []
volume = {25:7}
journal type = {AC}
place = {United Kingdom}
year = {1984}
month = {Jul}
}