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Inhibition of cellular oxidation by fluoride

Journal Article:

Abstract

An attempt has been made to investigate the inhibition by fluoride of the oxidative processes which occur in the cell by way of the cytochrome oxidase-cytochrome system. Some chemical and physical properties of the fluoride ion are discussed, together with certain quantitative methods for the determination of fluoride. An exhaustive review of the literature concerning the effect of fluoride on enzymic processes has been compiled. The experiments have shown that the point of the attack by fluoride is to be found among the cytochromes. The inhibitory mechanism appears to be such that the haemoprotein is prevented from taking part in the preceding and succeeding links in the reaction chain. The blocking action leaves the prosthetic group of the haemoprotein completely unchanged. The experimental results indicate the formation of a fluorophosphoprotein complex, analogous to that found in the case of enolase. Magnesium may possibly play a part in this process.
Authors:
Publication Date:
Jan 01, 1945
Product Type:
Journal Article
Reference Number:
EDB-85-049296
Resource Relation:
Journal Name: Ark. Kemi, Mineral. Geol.; (Sweden); Journal Volume: 20A:8
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CYTOCHROME OXIDASE; ENZYME ACTIVITY; INHIBITION; FLUORIDES; BIOLOGICAL EFFECTS; CHEMICAL PROPERTIES; CYTOCHROMES; ENZYME INHIBITORS; MAGNESIUM; MEASURING METHODS; METABOLISM; PHYSICAL PROPERTIES; PROTEINS; RESPIRATION; RESPONSE MODIFYING FACTORS; REVIEWS; ALKALINE EARTH METALS; DOCUMENT TYPES; ELEMENTS; ENZYMES; FLUORINE COMPOUNDS; HAEM DEHYDROGENASES; HALIDES; HALOGEN COMPOUNDS; METALS; ORGANIC COMPOUNDS; OXIDOREDUCTASES; PIGMENTS; 560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)
OSTI ID:
6054008
Research Organizations:
Univ. of Stockholm, Sweden
Country of Origin:
Sweden
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: AKMGA
Submitting Site:
HEDB
Size:
Pages: 1-215
Announcement Date:

Journal Article:

Citation Formats

Borei, H. Inhibition of cellular oxidation by fluoride. Sweden: N. p., 1945. Web.
Borei, H. Inhibition of cellular oxidation by fluoride. Sweden.
Borei, H. 1945. "Inhibition of cellular oxidation by fluoride." Sweden.
@misc{etde_6054008,
title = {Inhibition of cellular oxidation by fluoride}
author = {Borei, H}
abstractNote = {An attempt has been made to investigate the inhibition by fluoride of the oxidative processes which occur in the cell by way of the cytochrome oxidase-cytochrome system. Some chemical and physical properties of the fluoride ion are discussed, together with certain quantitative methods for the determination of fluoride. An exhaustive review of the literature concerning the effect of fluoride on enzymic processes has been compiled. The experiments have shown that the point of the attack by fluoride is to be found among the cytochromes. The inhibitory mechanism appears to be such that the haemoprotein is prevented from taking part in the preceding and succeeding links in the reaction chain. The blocking action leaves the prosthetic group of the haemoprotein completely unchanged. The experimental results indicate the formation of a fluorophosphoprotein complex, analogous to that found in the case of enolase. Magnesium may possibly play a part in this process.}
journal = {Ark. Kemi, Mineral. Geol.; (Sweden)}
volume = {20A:8}
journal type = {AC}
place = {Sweden}
year = {1945}
month = {Jan}
}