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Effect of cadmium exposure on lipids, lipid peroxidation and metal distribution in rat brain regions

Journal Article:

Abstract

Effect of cadmium treatment on brain lipids, lipid peroxidation and distribution of Zn, Cu and Fe in rat brain regions was investigated. Adult male rats were exposed to Cd (100 ppm Cd as cadmium acetate) in drinking water for 30 days. The Cd exposure resulted in a significant decrease in the phospholipid content and an increase in the lipid peroxidation in the cerebral cortex and cerebellum. The total lipid content was not affected in any of the regions but a significant decrease in cholesterol and cerebroside contents were observed only in the cerebral cortex. A positive correlation between the increase in lipid peroxidation and decrease in the phospholipid content in the cerebral cortex and cerebellum was observed. A maximum accumulation of Cd occurred in the cerebral cortex. The Cu and Fe contents were significantly increased but the Zn levels decreased in the Cd-treated rats in all but the midbrain region. Results suggest that the increased peroxidation decomposition of structural lipids and the altered distribution of the essential trace metals in brain may play a significant role in Cd-induced neurotoxicity. 27 references, 2 tables.
Publication Date:
Jan 01, 1985
Product Type:
Journal Article
Reference Number:
EDB-86-045108
Resource Relation:
Journal Name: Ind. Health (Kawasaki); (Japan); Journal Volume: 23:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CADMIUM; BIOLOGICAL ACCUMULATION; TOXICITY; COPPER; TISSUE DISTRIBUTION; IRON; LIPIDS; DECOMPOSITION; ZINC; BRAIN; CHOLESTEROL; EXPERIMENTAL DATA; METABOLISM; PHOSPHOLIPIDS; RATS; ANIMALS; BODY; CENTRAL NERVOUS SYSTEM; CHEMICAL REACTIONS; DATA; DISTRIBUTION; ELEMENTS; ESTERS; HYDROXY COMPOUNDS; INFORMATION; MAMMALS; METALS; NERVOUS SYSTEM; NUMERICAL DATA; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; ORGANS; RODENTS; STEROIDS; STEROLS; TRANSITION ELEMENTS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
6037317
Research Organizations:
Industrial Toxicology Research Centre, Lucknow, India
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: INHEA
Submitting Site:
HEDB
Size:
Pages: 199-205
Announcement Date:

Journal Article:

Citation Formats

Hussain, T, Ali, M M, and Chandra, S V. Effect of cadmium exposure on lipids, lipid peroxidation and metal distribution in rat brain regions. Japan: N. p., 1985. Web. doi:10.2486/indhealth.23.199.
Hussain, T, Ali, M M, & Chandra, S V. Effect of cadmium exposure on lipids, lipid peroxidation and metal distribution in rat brain regions. Japan. doi:10.2486/indhealth.23.199.
Hussain, T, Ali, M M, and Chandra, S V. 1985. "Effect of cadmium exposure on lipids, lipid peroxidation and metal distribution in rat brain regions." Japan. doi:10.2486/indhealth.23.199. https://www.osti.gov/servlets/purl/10.2486/indhealth.23.199.
@misc{etde_6037317,
title = {Effect of cadmium exposure on lipids, lipid peroxidation and metal distribution in rat brain regions}
author = {Hussain, T, Ali, M M, and Chandra, S V}
abstractNote = {Effect of cadmium treatment on brain lipids, lipid peroxidation and distribution of Zn, Cu and Fe in rat brain regions was investigated. Adult male rats were exposed to Cd (100 ppm Cd as cadmium acetate) in drinking water for 30 days. The Cd exposure resulted in a significant decrease in the phospholipid content and an increase in the lipid peroxidation in the cerebral cortex and cerebellum. The total lipid content was not affected in any of the regions but a significant decrease in cholesterol and cerebroside contents were observed only in the cerebral cortex. A positive correlation between the increase in lipid peroxidation and decrease in the phospholipid content in the cerebral cortex and cerebellum was observed. A maximum accumulation of Cd occurred in the cerebral cortex. The Cu and Fe contents were significantly increased but the Zn levels decreased in the Cd-treated rats in all but the midbrain region. Results suggest that the increased peroxidation decomposition of structural lipids and the altered distribution of the essential trace metals in brain may play a significant role in Cd-induced neurotoxicity. 27 references, 2 tables.}
doi = {10.2486/indhealth.23.199}
journal = {Ind. Health (Kawasaki); (Japan)}
volume = {23:3}
journal type = {AC}
place = {Japan}
year = {1985}
month = {Jan}
}