Abstract
Exposure of guinea pigs for 8 hr to H/sub 2/SO/sub 4/ mist (2.7 ..mu..m MMD) yielded an LC/sub 50/ of 6.8 ppM. Animals either became dyspneic within 3 hr and died within 8 hr or suffered little effect during exposure. Some animals were particularly resistant. LC/sub 50/ for mist of 0.8 ..mu..m MMD was 14.9 ppM at room temperature (20/sup 0/C) and 11.7 ppM at 0/sup 0/C. Decrease was significant at 2% level. That cold especially affects more resistant animals is suggested. No evidence for tolerance was observed. Ammonium carbonate (NH/sub 3/ to neutralize mist) negated mortal effect of mist sufficient to produce > 50% mortality. Fatal effect was laryngeal spasm and bronchoconstriction. Pathology included emphysematous lungs. No pathological findings were observed in animals surviving short LC/sub 50/, but prolonged exposure produced slowly-repairable pathological lesions including capillary engorgement (perhaps sequel to bronchospasm).
Citation Formats
Pattle, R E, Burgess, F, and Cullumbine, H.
Effects of a cold environment and of ammonia on the toxicity of sulfuric acid mist to guinea pigs.
United Kingdom: N. p.,
1956.
Web.
doi:10.1002/path.1700720128.
Pattle, R E, Burgess, F, & Cullumbine, H.
Effects of a cold environment and of ammonia on the toxicity of sulfuric acid mist to guinea pigs.
United Kingdom.
https://doi.org/10.1002/path.1700720128
Pattle, R E, Burgess, F, and Cullumbine, H.
1956.
"Effects of a cold environment and of ammonia on the toxicity of sulfuric acid mist to guinea pigs."
United Kingdom.
https://doi.org/10.1002/path.1700720128.
@misc{etde_6035915,
title = {Effects of a cold environment and of ammonia on the toxicity of sulfuric acid mist to guinea pigs}
author = {Pattle, R E, Burgess, F, and Cullumbine, H}
abstractNote = {Exposure of guinea pigs for 8 hr to H/sub 2/SO/sub 4/ mist (2.7 ..mu..m MMD) yielded an LC/sub 50/ of 6.8 ppM. Animals either became dyspneic within 3 hr and died within 8 hr or suffered little effect during exposure. Some animals were particularly resistant. LC/sub 50/ for mist of 0.8 ..mu..m MMD was 14.9 ppM at room temperature (20/sup 0/C) and 11.7 ppM at 0/sup 0/C. Decrease was significant at 2% level. That cold especially affects more resistant animals is suggested. No evidence for tolerance was observed. Ammonium carbonate (NH/sub 3/ to neutralize mist) negated mortal effect of mist sufficient to produce > 50% mortality. Fatal effect was laryngeal spasm and bronchoconstriction. Pathology included emphysematous lungs. No pathological findings were observed in animals surviving short LC/sub 50/, but prolonged exposure produced slowly-repairable pathological lesions including capillary engorgement (perhaps sequel to bronchospasm).}
doi = {10.1002/path.1700720128}
journal = []
volume = {72}
journal type = {AC}
place = {United Kingdom}
year = {1956}
month = {Jan}
}
title = {Effects of a cold environment and of ammonia on the toxicity of sulfuric acid mist to guinea pigs}
author = {Pattle, R E, Burgess, F, and Cullumbine, H}
abstractNote = {Exposure of guinea pigs for 8 hr to H/sub 2/SO/sub 4/ mist (2.7 ..mu..m MMD) yielded an LC/sub 50/ of 6.8 ppM. Animals either became dyspneic within 3 hr and died within 8 hr or suffered little effect during exposure. Some animals were particularly resistant. LC/sub 50/ for mist of 0.8 ..mu..m MMD was 14.9 ppM at room temperature (20/sup 0/C) and 11.7 ppM at 0/sup 0/C. Decrease was significant at 2% level. That cold especially affects more resistant animals is suggested. No evidence for tolerance was observed. Ammonium carbonate (NH/sub 3/ to neutralize mist) negated mortal effect of mist sufficient to produce > 50% mortality. Fatal effect was laryngeal spasm and bronchoconstriction. Pathology included emphysematous lungs. No pathological findings were observed in animals surviving short LC/sub 50/, but prolonged exposure produced slowly-repairable pathological lesions including capillary engorgement (perhaps sequel to bronchospasm).}
doi = {10.1002/path.1700720128}
journal = []
volume = {72}
journal type = {AC}
place = {United Kingdom}
year = {1956}
month = {Jan}
}