You need JavaScript to view this

Efferent connections and nigral afferents of the nucleus accumbens septi in the rat

Abstract

The results of this study by the methods of autoradiographic fiber-tracing and retrograde cell-labelling confirm earlier reports of accumbens projections to the globus pallidus and to dorsal strata of the medial half of the substantia nigra. Also in accord with previous autoradiographic evidence, sparser projections could be traced to a variety of subcortical structures implicated in the circuitry of the limbic system: bed nucleus of the stria terminalis, septum, preoptic region, hypothalamus, ventral tegmental area, nuclei paratenialis and mediodorsalis thalami, and lateral habenular nucleus. Contrary to earlier reports, striatopallidal fibers from the accumbens were found to be distributed largely to the subcommissural part of the external pallidal segment and to avoid almost entirely the internal pallidal segment. Mesencephalic projections from the accumbens largely coincide with those from the preoptic region and hypothalamus; like the latter they prominantly involve the region of the out-lying nigral cell groups A10 and A8 and extend caudally beyond the nigral complex to the cuneiform and parabrachial regions of the tegmentum as well as to caudoventral parts of the central grey substance. Horseradish peroxidase injected into the nucleus accumbens labels numerous neurons in the region of cell group A10 and in the supralemniscal 'retrorubral nucleus', but  More>>
Authors:
Nauta, W J.H.; Smith, G P; Faull, R L.M.; Domesick, V B [1] 
  1. Massachusetts Inst. of Tech., Cambridge (USA). Dept. of Psychology
Publication Date:
Jan 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-10-423441; EDB-79-101375
Resource Relation:
Journal Name: Neuroscience; (United Kingdom); Journal Volume: 3
Subject:
59 BASIC BIOLOGICAL SCIENCES; NERVE CELLS; BIOLOGICAL LOCALIZATION; NERVE TISSUE; AUTORADIOGRAPHY; AMINO ACIDS; BRAIN; DISTRIBUTION; FIBERS; INJECTION; LABELLED COMPOUNDS; PEROXIDASES; RATS; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ANIMAL CELLS; ANIMALS; BODY; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; ENZYMES; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; INTAKE; ISOTOPE APPLICATIONS; MAMMALS; NERVOUS SYSTEM; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; OXIDOREDUCTASES; PORPHYRINS; RODENTS; SOMATIC CELLS; TISSUES; VERTEBRATES; 550801* - Morphology- Tracer Techniques; 551001 - Physiological Systems- Tracer Techniques
OSTI ID:
6031122
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: NRSCD
Submitting Site:
INIS
Size:
Pages: 385-401
Announcement Date:

Citation Formats

Nauta, W J.H., Smith, G P, Faull, R L.M., and Domesick, V B. Efferent connections and nigral afferents of the nucleus accumbens septi in the rat. United Kingdom: N. p., 1978. Web. doi:10.1016/0306-4522(78)90041-6.
Nauta, W J.H., Smith, G P, Faull, R L.M., & Domesick, V B. Efferent connections and nigral afferents of the nucleus accumbens septi in the rat. United Kingdom. doi:10.1016/0306-4522(78)90041-6.
Nauta, W J.H., Smith, G P, Faull, R L.M., and Domesick, V B. 1978. "Efferent connections and nigral afferents of the nucleus accumbens septi in the rat." United Kingdom. doi:10.1016/0306-4522(78)90041-6. https://www.osti.gov/servlets/purl/10.1016/0306-4522(78)90041-6.
@misc{etde_6031122,
title = {Efferent connections and nigral afferents of the nucleus accumbens septi in the rat}
author = {Nauta, W J.H., Smith, G P, Faull, R L.M., and Domesick, V B}
abstractNote = {The results of this study by the methods of autoradiographic fiber-tracing and retrograde cell-labelling confirm earlier reports of accumbens projections to the globus pallidus and to dorsal strata of the medial half of the substantia nigra. Also in accord with previous autoradiographic evidence, sparser projections could be traced to a variety of subcortical structures implicated in the circuitry of the limbic system: bed nucleus of the stria terminalis, septum, preoptic region, hypothalamus, ventral tegmental area, nuclei paratenialis and mediodorsalis thalami, and lateral habenular nucleus. Contrary to earlier reports, striatopallidal fibers from the accumbens were found to be distributed largely to the subcommissural part of the external pallidal segment and to avoid almost entirely the internal pallidal segment. Mesencephalic projections from the accumbens largely coincide with those from the preoptic region and hypothalamus; like the latter they prominantly involve the region of the out-lying nigral cell groups A10 and A8 and extend caudally beyond the nigral complex to the cuneiform and parabrachial regions of the tegmentum as well as to caudoventral parts of the central grey substance. Horseradish peroxidase injected into the nucleus accumbens labels numerous neurons in the region of cell group A10 and in the supralemniscal 'retrorubral nucleus', but only sporadic cells in the pars compacta of the substantia nigra proper. It thus appears that the accumbens projects to a region of the nigral complex considerably larger than that from which it receives nigrostriatal fibers, and hence, that the nigro-striato-nigral circuit associated with the accumbens is not organized in a mode of simple point-for-point reciprocity. The problem of delimiting the accumbens from the rest of the striatum is examined by comparing cases of tracer injection into various discrete loci within the ventral zone of the striatum.}
doi = {10.1016/0306-4522(78)90041-6}
journal = {Neuroscience; (United Kingdom)}
volume = {3}
journal type = {AC}
place = {United Kingdom}
year = {1978}
month = {Jan}
}