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Effect of protein malnutrition on the metabolism of bone collagen in albino rats

Abstract

The effect of protein malnutrition on the metabolism of collagen in bone was studied in young female albino rats after a single injection of /sup 3/H-proline. Both specific and total radioactivities of hydroxyproline in the total collagen of the bone were found to decrease in the protein-deficient animals, indicating decreased rate of collagen synthesis. In the urine the amount of hydroxyproline excreted and total radioactivity of /sup 3/H-hydroxyproline were greatly decreased. The results of the present investigation therefore clearly indicate decreased synthesis and catabolism of collagen in bones of protein deficient animals compared to controls.
Authors:
Rao, J S; Rao, V H [1] 
  1. Central Leather Research Inst., Madras (India)
Publication Date:
Jan 01, 1981
Product Type:
Journal Article
Reference Number:
AIX-12-641366; EDB-82-032453
Resource Relation:
Journal Name: Leather Sci. (Madras); (India); Journal Volume: 28:1
Subject:
59 BASIC BIOLOGICAL SCIENCES; COLLAGEN; METABOLISM; BIOSYNTHESIS; LABELLED COMPOUNDS; NUTRITIONAL DEFICIENCY; PROLINE; RATS; SKELETON; TRACER TECHNIQUES; TRITIUM COMPOUNDS; AMINES; AMINO ACIDS; ANIMALS; AZOLES; BODY; CARBOXYLIC ACIDS; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; ISOTOPE APPLICATIONS; MAMMALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PROTEINS; PYRROLES; PYRROLIDINES; RODENTS; SCLEROPROTEINS; SYNTHESIS; VERTEBRATES; 550501* - Metabolism- Tracer Techniques
OSTI ID:
6029166
Country of Origin:
India
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: LESCA
Submitting Site:
INIS
Size:
Pages: 1-4
Announcement Date:
Dec 01, 1981

Citation Formats

Rao, J S, and Rao, V H. Effect of protein malnutrition on the metabolism of bone collagen in albino rats. India: N. p., 1981. Web.
Rao, J S, & Rao, V H. Effect of protein malnutrition on the metabolism of bone collagen in albino rats. India.
Rao, J S, and Rao, V H. 1981. "Effect of protein malnutrition on the metabolism of bone collagen in albino rats." India.
@misc{etde_6029166,
title = {Effect of protein malnutrition on the metabolism of bone collagen in albino rats}
author = {Rao, J S, and Rao, V H}
abstractNote = {The effect of protein malnutrition on the metabolism of collagen in bone was studied in young female albino rats after a single injection of /sup 3/H-proline. Both specific and total radioactivities of hydroxyproline in the total collagen of the bone were found to decrease in the protein-deficient animals, indicating decreased rate of collagen synthesis. In the urine the amount of hydroxyproline excreted and total radioactivity of /sup 3/H-hydroxyproline were greatly decreased. The results of the present investigation therefore clearly indicate decreased synthesis and catabolism of collagen in bones of protein deficient animals compared to controls.}
journal = {Leather Sci. (Madras); (India)}
volume = {28:1}
journal type = {AC}
place = {India}
year = {1981}
month = {Jan}
}