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Hematologic long-term modifications after radio-iodine therapy in carcinoma of the thyroid gland. Pt. 2. Modifications of the bone marrow including leukemia

Journal Article:

Abstract

59 posttherapeutic examinations of the bone marrow have been performed in 35 patients out of a group of 296 patients treated from 1969 through 1976 by postoperative iodine-131 irradiations for carcinoma of the thyroid gland. Seven patients had normal findings, twelve patients showed panmyelopathy as principal finding, and fourteen patients presented modifications of the three marrow systems in differents degrees and combinations. Acute myeloid leukemia was demonstrated in two patients by examination of the bone marrow, in another case the same disease was diagnosed by an analysis of the peripheral blood count. Taking into account the dosimetric considerations of the authors and the three cases of leukemia observed within the total group of patients, a risk factor for leukemia of 7.0x10/sup -5/xrd/sup -1/ is calculated which is slightly higher than he leukemia induction rate communicated in literature (22/2646 patients; 1-2/100 000/rd/year).
Publication Date:
Jul 01, 1987
Product Type:
Journal Article
Reference Number:
DEN-87-013075; EDB-87-151084
Resource Relation:
Journal Name: Strahlenther. Onkol.; (Germany, Federal Republic of); Journal Volume: 163:7
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; RADIOTHERAPY; DELAYED RADIATION EFFECTS; LEUKEMOGENESIS; BONE MARROW; BONE MARROW CELLS; CARCINOMAS; HEMATOLOGY; IODINE 131; LEUKEMIA; PATIENTS; THYROID; ANIMAL CELLS; ANIMAL TISSUES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CARCINOGENESIS; CONNECTIVE TISSUE CELLS; DAYS LIVING RADIOISOTOPES; DISEASES; ENDOCRINE GLANDS; GLANDS; HEMATOPOIETIC SYSTEM; HEMIC DISEASES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PATHOGENESIS; RADIATION EFFECTS; RADIOISOTOPES; RADIOLOGY; SOMATIC CELLS; THERAPY; TISSUES; 560161* - Radionuclide Effects, Kinetics, & Toxicology- Man; 550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)
OSTI ID:
6020950
Research Organizations:
Medizinische Hochschule Hannover, Germany, F.R.. Abt. Nuklearmedizin und Spezielle Biophysik
Country of Origin:
Germany
Language:
German
Other Identifying Numbers:
Journal ID: CODEN: STONE
Submitting Site:
DEN
Size:
Pages: 475-485
Announcement Date:

Journal Article:

Citation Formats

Guenter, H H, Schober, O, Schwarzrock, R, and Hundeshagen, H. Hematologic long-term modifications after radio-iodine therapy in carcinoma of the thyroid gland. Pt. 2. Modifications of the bone marrow including leukemia. Germany: N. p., 1987. Web.
Guenter, H H, Schober, O, Schwarzrock, R, & Hundeshagen, H. Hematologic long-term modifications after radio-iodine therapy in carcinoma of the thyroid gland. Pt. 2. Modifications of the bone marrow including leukemia. Germany.
Guenter, H H, Schober, O, Schwarzrock, R, and Hundeshagen, H. 1987. "Hematologic long-term modifications after radio-iodine therapy in carcinoma of the thyroid gland. Pt. 2. Modifications of the bone marrow including leukemia." Germany.
@misc{etde_6020950,
title = {Hematologic long-term modifications after radio-iodine therapy in carcinoma of the thyroid gland. Pt. 2. Modifications of the bone marrow including leukemia}
author = {Guenter, H H, Schober, O, Schwarzrock, R, and Hundeshagen, H}
abstractNote = {59 posttherapeutic examinations of the bone marrow have been performed in 35 patients out of a group of 296 patients treated from 1969 through 1976 by postoperative iodine-131 irradiations for carcinoma of the thyroid gland. Seven patients had normal findings, twelve patients showed panmyelopathy as principal finding, and fourteen patients presented modifications of the three marrow systems in differents degrees and combinations. Acute myeloid leukemia was demonstrated in two patients by examination of the bone marrow, in another case the same disease was diagnosed by an analysis of the peripheral blood count. Taking into account the dosimetric considerations of the authors and the three cases of leukemia observed within the total group of patients, a risk factor for leukemia of 7.0x10/sup -5/xrd/sup -1/ is calculated which is slightly higher than he leukemia induction rate communicated in literature (22/2646 patients; 1-2/100 000/rd/year).}
journal = {Strahlenther. Onkol.; (Germany, Federal Republic of)}
volume = {163:7}
journal type = {AC}
place = {Germany}
year = {1987}
month = {Jul}
}