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DMSO does not protect against hydroxyl radical induced peroxidation in model membranes

Journal Article:

Abstract

Dimethylsulphoxide (DMSO) promoted peroxidation in both linolenate and linoleate micelles. The promotional effect was most evident at concentrations of DMSO above 0.3 M with 0.012 M fatty acid. This was well above the DMSO concentration at which all the OH was scavenged by DMSO on the basis of the relative rate constants recorded. It was also found that DMSO did not decrease the yield of lipid hydroperoxide in a concentration range (0.01 to 0.1 M) where DMSO scavenges OH in competition with the unsaturated fatty acids. The sustaining mechanism could be accounted for in terms of CHsup(.)/sub 3/ and CH/sub 3/OOsup(.) being as effective as OH in initiating lipid peroxidation. A possible alternative explanation for the absence of protection by DMSO is that OH scavenging by DMSO is equivalent to lowering the dose-rate. The promotion of peroxidation at high DMSO concentration (> 1.0 M) was more difficult to account for, but may be analogous to the promotional effect of caesium and rubidium counterions.
Authors:
Raleigh, J A; Kremers, W [1] 
  1. Atomic Energy of Canada Ltd., Pinawa, Manitoba. Whiteshell Nuclear Research Establishment
Publication Date:
Apr 01, 1981
Product Type:
Journal Article
Reference Number:
AIX-12-615900; EDB-81-131945
Resource Relation:
Journal Name: Int. J. Radiat. Biol. Relat. Stud. Phys., Chem. Med.; (United Kingdom); Journal Volume: 39:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DMSO; BIOLOGICAL EFFECTS; LINOLEIC ACID; OXIDATION; LINOLENIC ACID; LIPIDS; BIOLOGICAL RADIATION EFFECTS; DILUTION; HYDROXYL RADICALS; PEROXIDES; RADIOPROTECTIVE SUBSTANCES; SCAVENGING; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; DRUGS; MONOCARBOXYLIC ACIDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; OXYGEN COMPOUNDS; RADIATION EFFECTS; RADICALS; SULFOXIDES; 560111* - Radiation Effects on Biochemicals- In Vitro- (-1987)
OSTI ID:
6013304
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: IJRBA
Submitting Site:
INIS
Size:
Pages: 441-444
Announcement Date:
Aug 01, 1981

Journal Article:

Citation Formats

Raleigh, J A, and Kremers, W. DMSO does not protect against hydroxyl radical induced peroxidation in model membranes. United Kingdom: N. p., 1981. Web.
Raleigh, J A, & Kremers, W. DMSO does not protect against hydroxyl radical induced peroxidation in model membranes. United Kingdom.
Raleigh, J A, and Kremers, W. 1981. "DMSO does not protect against hydroxyl radical induced peroxidation in model membranes." United Kingdom.
@misc{etde_6013304,
title = {DMSO does not protect against hydroxyl radical induced peroxidation in model membranes}
author = {Raleigh, J A, and Kremers, W}
abstractNote = {Dimethylsulphoxide (DMSO) promoted peroxidation in both linolenate and linoleate micelles. The promotional effect was most evident at concentrations of DMSO above 0.3 M with 0.012 M fatty acid. This was well above the DMSO concentration at which all the OH was scavenged by DMSO on the basis of the relative rate constants recorded. It was also found that DMSO did not decrease the yield of lipid hydroperoxide in a concentration range (0.01 to 0.1 M) where DMSO scavenges OH in competition with the unsaturated fatty acids. The sustaining mechanism could be accounted for in terms of CHsup(.)/sub 3/ and CH/sub 3/OOsup(.) being as effective as OH in initiating lipid peroxidation. A possible alternative explanation for the absence of protection by DMSO is that OH scavenging by DMSO is equivalent to lowering the dose-rate. The promotion of peroxidation at high DMSO concentration (> 1.0 M) was more difficult to account for, but may be analogous to the promotional effect of caesium and rubidium counterions.}
journal = {Int. J. Radiat. Biol. Relat. Stud. Phys., Chem. Med.; (United Kingdom)}
volume = {39:4}
journal type = {AC}
place = {United Kingdom}
year = {1981}
month = {Apr}
}