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Carrier-added and no-carrier-added syntheses of (/sup 18/F)spiroperidol and (/sup 18/F)haloperidol

Abstract

Syntheses of (/sup 18/F)haloperidol and (/sup 18/F)spiroperidol in both no-carrier-added and carrier-added forms have been accomplished. The no-carrier-added (/sup 18/F)butyrophenone neuroleptics were prepared in low (<2%) yield by acid decomposition of aryl piperidine triazenes. Carrier-added /sup 18/F-neuroleptics were prepared in better (5-17%) yields by /sup 18/F-for-/sup 19/F nucleophilic aromatic substitution. The preparation of all synthetic precursors, and procedures for radiolabeling are fully described.
Authors:
Kilbourn, M R; Welch, M J; Dence, C S; Tewson, T J; Saji, H; Maeda, M [1] 
  1. Washington Univ., St. Louis, MO (USA). Edward Mallinckrodt Inst. of Radiology
Publication Date:
Jul 01, 1984
Product Type:
Journal Article
Reference Number:
AIX-15-069440; EDB-85-055098
Resource Relation:
Journal Name: Int. J. Appl. Radiat. Isot.; (United Kingdom); Journal Volume: 35:7
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; ORGANIC FLUORINE COMPOUNDS; LABELLING; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; AROMATICS; CARRIER-FREE ISOTOPES; CHEMICAL REACTION YIELD; DECOMPOSITION; DOPAMINE; FLUORINE 18; KETONES; LIQUID COLUMN CHROMATOGRAPHY; PH VALUE; PIPERIDINES; SYMPATHOMIMETICS; TRIAZINES; AMINES; AUTONOMIC NERVOUS SYSTEM AGENTS; AZINES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARDIOTONICS; CARDIOVASCULAR AGENTS; CHEMICAL REACTIONS; CHROMATOGRAPHY; DRUGS; FLUORINE ISOTOPES; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; NEUROREGULATORS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PHENOLS; POLYPHENOLS; PYRIDINES; RADIOISOTOPES; SEPARATION PROCESSES; SYNTHESIS; YIELDS; 400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
OSTI ID:
6008645
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: IJARA
Submitting Site:
HEDB
Size:
Pages: 591-598
Announcement Date:

Citation Formats

Kilbourn, M R, Welch, M J, Dence, C S, Tewson, T J, Saji, H, and Maeda, M. Carrier-added and no-carrier-added syntheses of (/sup 18/F)spiroperidol and (/sup 18/F)haloperidol. United Kingdom: N. p., 1984. Web. doi:10.1016/0020-708X(84)90101-7.
Kilbourn, M R, Welch, M J, Dence, C S, Tewson, T J, Saji, H, & Maeda, M. Carrier-added and no-carrier-added syntheses of (/sup 18/F)spiroperidol and (/sup 18/F)haloperidol. United Kingdom. doi:10.1016/0020-708X(84)90101-7.
Kilbourn, M R, Welch, M J, Dence, C S, Tewson, T J, Saji, H, and Maeda, M. 1984. "Carrier-added and no-carrier-added syntheses of (/sup 18/F)spiroperidol and (/sup 18/F)haloperidol." United Kingdom. doi:10.1016/0020-708X(84)90101-7. https://www.osti.gov/servlets/purl/10.1016/0020-708X(84)90101-7.
@misc{etde_6008645,
title = {Carrier-added and no-carrier-added syntheses of (/sup 18/F)spiroperidol and (/sup 18/F)haloperidol}
author = {Kilbourn, M R, Welch, M J, Dence, C S, Tewson, T J, Saji, H, and Maeda, M}
abstractNote = {Syntheses of (/sup 18/F)haloperidol and (/sup 18/F)spiroperidol in both no-carrier-added and carrier-added forms have been accomplished. The no-carrier-added (/sup 18/F)butyrophenone neuroleptics were prepared in low (<2%) yield by acid decomposition of aryl piperidine triazenes. Carrier-added /sup 18/F-neuroleptics were prepared in better (5-17%) yields by /sup 18/F-for-/sup 19/F nucleophilic aromatic substitution. The preparation of all synthetic precursors, and procedures for radiolabeling are fully described.}
doi = {10.1016/0020-708X(84)90101-7}
journal = {Int. J. Appl. Radiat. Isot.; (United Kingdom)}
volume = {35:7}
journal type = {AC}
place = {United Kingdom}
year = {1984}
month = {Jul}
}