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Osteoporosis and hydronephrosis of young lambs following the ingestion of lead

Abstract

Lead poisoning is described in young lambs which were reared near lead mining areas in North Derbyshire, England. A brief history of the poisoning of stock which has occurred in the past near lead workings is given. The clinical results and post-mortem findings are reported together with descriptions of radiographical, histological and biochemical findings. A striking feature of all post-mortem examinations was an emaciated carcase with grossly abnormal kidneys. The bones were fragile and easily broken or cut. Kidney cortex and liver lead estimations were carried out in every case. The response of affected lambs to treatment with ascorbic acid is described and the similarities of the clinical signs and the skeletal lesions to scurvy in man and the guinea pig are discussed. 31 references, 6 figures, 2 tables.
Publication Date:
Jan 01, 1966
Product Type:
Journal Article
Reference Number:
ERA-10-021905; EDB-85-061095
Resource Relation:
Journal Name: J. Comp. Pathol.; (United Kingdom); Journal Volume: 76:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; KIDNEYS; CHEMICAL ANALYSIS; MALFORMATIONS; LEAD; TOXICITY; LIVER; SHEEP; NEPHRITIS; OSTEOPOROSIS; SKELETON; INJURIES; UNITED KINGDOM; LAND POLLUTION; ASCORBIC ACID; CONTAMINATION; ENVIRONMENTAL EFFECTS; INGESTION; LEAD ORES; MINING; ANIMALS; BODY; DIGESTIVE SYSTEM; DISEASES; DOMESTIC ANIMALS; ELEMENTS; EUROPE; GLANDS; INTAKE; MAMMALS; METALS; ORES; ORGANS; PATHOLOGICAL CHANGES; POLLUTION; RUMINANTS; SKELETAL DISEASES; UROGENITAL SYSTEM DISEASES; VERTEBRATES; VITAMINS; WESTERN EUROPE; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
5997812
Research Organizations:
Veterinary Investigation Centre, Sutton, England
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JCVPA
Submitting Site:
HEDB
Size:
Pages: 15-22
Announcement Date:
Mar 01, 1985

Citation Formats

Clegg, F G, and Rylands, J M. Osteoporosis and hydronephrosis of young lambs following the ingestion of lead. United Kingdom: N. p., 1966. Web. doi:10.1016/0021-9975(66)90043-0.
Clegg, F G, & Rylands, J M. Osteoporosis and hydronephrosis of young lambs following the ingestion of lead. United Kingdom. https://doi.org/10.1016/0021-9975(66)90043-0
Clegg, F G, and Rylands, J M. 1966. "Osteoporosis and hydronephrosis of young lambs following the ingestion of lead." United Kingdom. https://doi.org/10.1016/0021-9975(66)90043-0.
@misc{etde_5997812,
title = {Osteoporosis and hydronephrosis of young lambs following the ingestion of lead}
author = {Clegg, F G, and Rylands, J M}
abstractNote = {Lead poisoning is described in young lambs which were reared near lead mining areas in North Derbyshire, England. A brief history of the poisoning of stock which has occurred in the past near lead workings is given. The clinical results and post-mortem findings are reported together with descriptions of radiographical, histological and biochemical findings. A striking feature of all post-mortem examinations was an emaciated carcase with grossly abnormal kidneys. The bones were fragile and easily broken or cut. Kidney cortex and liver lead estimations were carried out in every case. The response of affected lambs to treatment with ascorbic acid is described and the similarities of the clinical signs and the skeletal lesions to scurvy in man and the guinea pig are discussed. 31 references, 6 figures, 2 tables.}
doi = {10.1016/0021-9975(66)90043-0}
journal = []
volume = {76:1}
journal type = {AC}
place = {United Kingdom}
year = {1966}
month = {Jan}
}