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Role of p-aminobenzoic acid in the repair of injuries induced by UV- and. gamma. -radiation

Journal Article:

Abstract

For the first time it was proved that low doses of p-aminobenzoic acid (PABA) were capable of sharply decreasing lethal mutational effects of UV light and less significantly-gamma effect on a bacterial cell. The experiments were carried out on E.Coli strains which differed in the activity of ferment system of DNA UV-induced injuries reparation. UV radiation dose equaled 10-1500 erd/mm/sup 2/. PABA capability to intensify the reparative process under mutagenic effects of 3 main types: chemical, UV as a representative of non-penetrating radiation, and penetrating radiation permitted to characterize this compound as ''reparagen''. It was emphasized that the application of reparagens capable of intensifying or weakening the reparative process permitted to observe different effects of reparation dependence on the concentration of a chemical agent being introduced from outside and localize the process of reparagen effect in time.
Authors:
Rapoport, I A; Vasil'eva, S V; Davnichenko, L S [1] 
  1. AN SSSR, Moscow. Inst. Khimicheskoj Fiziki
Publication Date:
Jul 01, 1979
Product Type:
Journal Article
Reference Number:
AIX-12-629345; EDB-82-023079
Resource Relation:
Journal Name: Dokl. Akad. Nauk SSSR; (USSR); Journal Volume: 247:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DNA; BIOLOGICAL REPAIR; PABA; RADIOSENSITIVITY EFFECTS; BIOLOGICAL EFFECTS; ESCHERICHIA COLI; GAMMA RADIATION; RADIATION DOSES; RADIATION INJURIES; ULTRAVIOLET RADIATION; AMINO ACIDS; BACTERIA; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; CARBOXYLIC ACIDS; DOSES; ELECTROMAGNETIC RADIATION; INJURIES; IONIZING RADIATIONS; MICROORGANISMS; NUCLEIC ACIDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RECOVERY; REPAIR; 560131* - Radiation Effects on Microorganisms- Basic Studies- (-1987)
OSTI ID:
5995840
Country of Origin:
USSR
Language:
Russian
Other Identifying Numbers:
Journal ID: CODEN: DANKA
Submitting Site:
INIS
Size:
Pages: 231-234
Announcement Date:

Journal Article:

Citation Formats

Rapoport, I A, Vasil'eva, S V, and Davnichenko, L S. Role of p-aminobenzoic acid in the repair of injuries induced by UV- and. gamma. -radiation. USSR: N. p., 1979. Web.
Rapoport, I A, Vasil'eva, S V, & Davnichenko, L S. Role of p-aminobenzoic acid in the repair of injuries induced by UV- and. gamma. -radiation. USSR.
Rapoport, I A, Vasil'eva, S V, and Davnichenko, L S. 1979. "Role of p-aminobenzoic acid in the repair of injuries induced by UV- and. gamma. -radiation." USSR.
@misc{etde_5995840,
title = {Role of p-aminobenzoic acid in the repair of injuries induced by UV- and. gamma. -radiation}
author = {Rapoport, I A, Vasil'eva, S V, and Davnichenko, L S}
abstractNote = {For the first time it was proved that low doses of p-aminobenzoic acid (PABA) were capable of sharply decreasing lethal mutational effects of UV light and less significantly-gamma effect on a bacterial cell. The experiments were carried out on E.Coli strains which differed in the activity of ferment system of DNA UV-induced injuries reparation. UV radiation dose equaled 10-1500 erd/mm/sup 2/. PABA capability to intensify the reparative process under mutagenic effects of 3 main types: chemical, UV as a representative of non-penetrating radiation, and penetrating radiation permitted to characterize this compound as ''reparagen''. It was emphasized that the application of reparagens capable of intensifying or weakening the reparative process permitted to observe different effects of reparation dependence on the concentration of a chemical agent being introduced from outside and localize the process of reparagen effect in time.}
journal = {Dokl. Akad. Nauk SSSR; (USSR)}
volume = {247:1}
journal type = {AC}
place = {USSR}
year = {1979}
month = {Jul}
}