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Studies of the activity of cytosol on the mixed disulfide bond formed by proteins and radioprotector mercaptoethylguanidine

Abstract

The cytoplasm of normal and tumorous rat liver cells contains a heat-resistant compound with reducing ability to break the mixed disulfide bond of albumin-/sup 14/C-mercaptoethylguanidine. The reducing activity of cytosol is destoryed by 1000 krd /sup 60/Co-gamma-ray doses in diluted solution. In vivo supralethal of rats does not affect the activity of cytosol prepared from liver cells.
Authors:
Horvath, M; [1]  Holland, J [2] 
  1. National Inst. of Oncology, Budapest (Hungary)
  2. Orszagos Onkologiai Intezet, Budapest (Hungary)
Publication Date:
Jan 01, 1979
Product Type:
Journal Article
Reference Number:
AIX-10-452127; EDB-79-096194
Resource Relation:
Journal Name: Strahlentherapie; (Germany, Federal Republic of); Journal Volume: 155:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANIMAL CELLS; RADIOSENSITIVITY; CHEMICAL BONDS; REDUCTION; MEG; BIOCHEMICAL REACTION KINETICS; BIOLOGICAL RADIATION EFFECTS; CELL CONSTITUENTS; CYTOPLASM; GAMMA RADIATION; INHIBITION; LIVER; PROTEINS; RATS; SUPRALETHAL IRRADIATION; TUMOR CELLS; ANIMALS; BIOLOGICAL EFFECTS; BODY; CARBONIC ACID DERIVATIVES; CHEMICAL REACTIONS; DIGESTIVE SYSTEM; DRUGS; ELECTROMAGNETIC RADIATION; GLANDS; IONIZING RADIATIONS; IRRADIATION; KINETICS; MAMMALS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOPROTECTIVE SUBSTANCES; REACTION KINETICS; RESPONSE MODIFYING FACTORS; RODENTS; THIOLS; VERTEBRATES; 550603* - Medicine- External Radiation in Therapy- (1980-); 560152 - Radiation Effects on Animals- Animals; 560121 - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
5994685
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: STRAA
Submitting Site:
INIS
Size:
Pages: 63-66
Announcement Date:
May 01, 1979

Citation Formats

Horvath, M, and Holland, J. Studies of the activity of cytosol on the mixed disulfide bond formed by proteins and radioprotector mercaptoethylguanidine. Germany: N. p., 1979. Web.
Horvath, M, & Holland, J. Studies of the activity of cytosol on the mixed disulfide bond formed by proteins and radioprotector mercaptoethylguanidine. Germany.
Horvath, M, and Holland, J. 1979. "Studies of the activity of cytosol on the mixed disulfide bond formed by proteins and radioprotector mercaptoethylguanidine." Germany.
@misc{etde_5994685,
title = {Studies of the activity of cytosol on the mixed disulfide bond formed by proteins and radioprotector mercaptoethylguanidine}
author = {Horvath, M, and Holland, J}
abstractNote = {The cytoplasm of normal and tumorous rat liver cells contains a heat-resistant compound with reducing ability to break the mixed disulfide bond of albumin-/sup 14/C-mercaptoethylguanidine. The reducing activity of cytosol is destoryed by 1000 krd /sup 60/Co-gamma-ray doses in diluted solution. In vivo supralethal of rats does not affect the activity of cytosol prepared from liver cells.}
journal = []
volume = {155:1}
journal type = {AC}
place = {Germany}
year = {1979}
month = {Jan}
}