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Depression of hyperglycemic response to glucagon by parenteral lead administration in sheep

Journal Article:

Abstract

The insulin and glucose responses to glucagon infusions (27 ..mu..g/hr) were determined in sheep before and after parenteral lead treatment (6 mg/kg intravenously). Glucose production was measured by primed continuous infusion of (6-/sup 3/H)glucose. Glucagon and insulin concentrations before and during glucagon infusions were not significantly different between lead treatment and control experiments. Lead administration did not affect the concentration or production of glucose in the preinfusion period. However, depressed hyperglycemia during glucagon infusion in lead treated experiments tended to be associated with decreased glucose production. The reduced glucogenic response to glucagon may be the result of reduced function of pyruvate carboxylase, a key hepatic gluconeogenic enzyme in sheep, from lead induced impairment of mitochondrial function. 21 references, 1 figure.
Authors:
Publication Date:
Jan 01, 1978
Product Type:
Journal Article
Reference Number:
EDB-85-056397
Resource Relation:
Journal Name: Can. J. Comp. Med.; (Canada); Journal Volume: 42:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ENZYME ACTIVITY; INHIBITION; LEAD; BIOLOGICAL EFFECTS; BIOLOGICAL FUNCTIONS; CARBOXYLASE; COMPARATIVE EVALUATIONS; EXPERIMENTAL DATA; MITOCHONDRIA; SHEEP; ANIMALS; CELL CONSTITUENTS; DATA; DOMESTIC ANIMALS; ELEMENTS; ENZYMES; FUNCTIONS; INFORMATION; LIGASES; MAMMALS; METALS; NUMERICAL DATA; ORGANOIDS; RUMINANTS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
5994457
Research Organizations:
Univ. of Saskatchewan, Saskatoon
Country of Origin:
Canada
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CJCMA
Submitting Site:
HEDB
Size:
Pages: 43-45
Announcement Date:

Journal Article:

Citation Formats

Brockman, R P. Depression of hyperglycemic response to glucagon by parenteral lead administration in sheep. Canada: N. p., 1978. Web.
Brockman, R P. Depression of hyperglycemic response to glucagon by parenteral lead administration in sheep. Canada.
Brockman, R P. 1978. "Depression of hyperglycemic response to glucagon by parenteral lead administration in sheep." Canada.
@misc{etde_5994457,
title = {Depression of hyperglycemic response to glucagon by parenteral lead administration in sheep}
author = {Brockman, R P}
abstractNote = {The insulin and glucose responses to glucagon infusions (27 ..mu..g/hr) were determined in sheep before and after parenteral lead treatment (6 mg/kg intravenously). Glucose production was measured by primed continuous infusion of (6-/sup 3/H)glucose. Glucagon and insulin concentrations before and during glucagon infusions were not significantly different between lead treatment and control experiments. Lead administration did not affect the concentration or production of glucose in the preinfusion period. However, depressed hyperglycemia during glucagon infusion in lead treated experiments tended to be associated with decreased glucose production. The reduced glucogenic response to glucagon may be the result of reduced function of pyruvate carboxylase, a key hepatic gluconeogenic enzyme in sheep, from lead induced impairment of mitochondrial function. 21 references, 1 figure.}
journal = {Can. J. Comp. Med.; (Canada)}
volume = {42:1}
journal type = {AC}
place = {Canada}
year = {1978}
month = {Jan}
}