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Adverse influence of ozone on pulmonary bactericidal activity of the murine lung

Abstract

Mice infected with /sup 32/P-labeled Staphylococcus aureus and subsequently (30 to 45 min) exposed to 0.62 to 4.25 ppM O/sub 3/ for 4 hr showed less bactericidal activity (negative at higher concentrations) than controls not exposed to O/sub 3/. Counts of /sup 32/P showed 5 to 20% loss (ciliary clearance) from 0 to 5 hr with no O/sub 3/ effect. Histologically, capillaries and small vessels were dilated with occasional edema at higher concentrations. Inhibition of macrophage function was thought to account for these results.
Publication Date:
Jan 01, 1971
Product Type:
Journal Article
Reference Number:
EDB-79-096512
Resource Relation:
Journal Name: Nature (London); (United Kingdom); Journal Volume: 229
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; MACROPHAGES; INHIBITION; OZONE; BIOLOGICAL EFFECTS; DOSE-RESPONSE RELATIONSHIPS; AIR POLLUTION; CAPILLARIES; EDEMA; LUNGS; MICE; RETICULOENDOTHELIAL SYSTEM; STAPHYLOCOCCUS; ANIMAL CELLS; ANIMALS; BACTERIA; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; CONNECTIVE TISSUE CELLS; DISEASES; MAMMALS; MICROORGANISMS; ORGANS; PATHOLOGICAL CHANGES; PHAGOCYTES; POLLUTION; RESPIRATORY SYSTEM; RODENTS; SOMATIC CELLS; SYMPTOMS; TISSUES; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 550700 - Microbiology; 551000 - Physiological Systems
OSTI ID:
5992466
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: NATUA
Submitting Site:
TIC
Size:
Pages: 262-263
Announcement Date:
Aug 01, 1979

Citation Formats

Goldstein, E, Tyler, W S, Hoeprich, P D, and Eagle, C. Adverse influence of ozone on pulmonary bactericidal activity of the murine lung. United Kingdom: N. p., 1971. Web. doi:10.1038/229262a0.
Goldstein, E, Tyler, W S, Hoeprich, P D, & Eagle, C. Adverse influence of ozone on pulmonary bactericidal activity of the murine lung. United Kingdom. https://doi.org/10.1038/229262a0
Goldstein, E, Tyler, W S, Hoeprich, P D, and Eagle, C. 1971. "Adverse influence of ozone on pulmonary bactericidal activity of the murine lung." United Kingdom. https://doi.org/10.1038/229262a0.
@misc{etde_5992466,
title = {Adverse influence of ozone on pulmonary bactericidal activity of the murine lung}
author = {Goldstein, E, Tyler, W S, Hoeprich, P D, and Eagle, C}
abstractNote = {Mice infected with /sup 32/P-labeled Staphylococcus aureus and subsequently (30 to 45 min) exposed to 0.62 to 4.25 ppM O/sub 3/ for 4 hr showed less bactericidal activity (negative at higher concentrations) than controls not exposed to O/sub 3/. Counts of /sup 32/P showed 5 to 20% loss (ciliary clearance) from 0 to 5 hr with no O/sub 3/ effect. Histologically, capillaries and small vessels were dilated with occasional edema at higher concentrations. Inhibition of macrophage function was thought to account for these results.}
doi = {10.1038/229262a0}
journal = []
volume = {229}
journal type = {AC}
place = {United Kingdom}
year = {1971}
month = {Jan}
}