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Asymmetry of cerebral blood flow in patients with senile dementia of Alzheimer type by SPECT using I-123 IMP

Journal Article:

Abstract

Regional cerebral blood flow (rCBF) was determined by single photon emission CT (SPECT) with N-isopropyl-p-({sup 123}I)iodoamphetamine in 22 patients with clinically diagnosed senile dementia of Alzheimer type (SDAT) and in 18 age matched controls. We calculated asymmetry indices (AIs) of rCBF for matched right-left regions of interest. rCBF of parietal lobe in SDAT patients was significantly most laterally asymmetrycal, but the least in occipital lobe. Lateral asymmetry of rCBF in SDAT patients correlated with asymmetry of language and visuospatial functions; decreased rCBF in the left parietal lobe was associated with language dysfunction, and that in the right parietal lobe, with viduospatial dysfunction. Furthermore cerebellar AIs correlated negatively with those of the cerebral hemisphere and lower frontal region in SDAT patients. The results demonstrate that rCBF measurement by {sup 123}I-IMP SPECT is useful to detect lateral asymmetry in reduction of rCBF in SDAT. (author).
Authors:
Publication Date:
Dec 01, 1990
Product Type:
Journal Article
Reference Number:
JPN-91-002351; EDB-91-041431
Resource Relation:
Journal Name: Kaku Igaku (Japanese Journal of Nuclear Medicine); (Japan); Journal Volume: 27:12
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CEREBRUM; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; IODINE 123; BENZEDRINE; BLOOD FLOW; CEREBELLUM; ELDERLY PEOPLE; MENTAL DISORDERS; AGE GROUPS; AGED ADULTS; AMINES; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HOURS LIVING RADIOISOTOPES; HUMAN POPULATIONS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MINORITY GROUPS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; POPULATIONS; RADIOISOTOPES; SYMPATHOMIMETICS; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5987251
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: ISSN 0022-7854; CODEN: KAIGB
Submitting Site:
JPN
Size:
Pages: 1401-1410
Announcement Date:

Journal Article:

Citation Formats

Arai, Hisayuki, Hanyu, Haruo, Kobayashi, Yasutaka, Hatano, Nobuyoshi, Katsunuma, Hideyo, Suzuki, Takanari, and Amino, Saburo. Asymmetry of cerebral blood flow in patients with senile dementia of Alzheimer type by SPECT using I-123 IMP. Japan: N. p., 1990. Web.
Arai, Hisayuki, Hanyu, Haruo, Kobayashi, Yasutaka, Hatano, Nobuyoshi, Katsunuma, Hideyo, Suzuki, Takanari, & Amino, Saburo. Asymmetry of cerebral blood flow in patients with senile dementia of Alzheimer type by SPECT using I-123 IMP. Japan.
Arai, Hisayuki, Hanyu, Haruo, Kobayashi, Yasutaka, Hatano, Nobuyoshi, Katsunuma, Hideyo, Suzuki, Takanari, and Amino, Saburo. 1990. "Asymmetry of cerebral blood flow in patients with senile dementia of Alzheimer type by SPECT using I-123 IMP." Japan.
@misc{etde_5987251,
title = {Asymmetry of cerebral blood flow in patients with senile dementia of Alzheimer type by SPECT using I-123 IMP}
author = {Arai, Hisayuki, Hanyu, Haruo, Kobayashi, Yasutaka, Hatano, Nobuyoshi, Katsunuma, Hideyo, Suzuki, Takanari, and Amino, Saburo}
abstractNote = {Regional cerebral blood flow (rCBF) was determined by single photon emission CT (SPECT) with N-isopropyl-p-({sup 123}I)iodoamphetamine in 22 patients with clinically diagnosed senile dementia of Alzheimer type (SDAT) and in 18 age matched controls. We calculated asymmetry indices (AIs) of rCBF for matched right-left regions of interest. rCBF of parietal lobe in SDAT patients was significantly most laterally asymmetrycal, but the least in occipital lobe. Lateral asymmetry of rCBF in SDAT patients correlated with asymmetry of language and visuospatial functions; decreased rCBF in the left parietal lobe was associated with language dysfunction, and that in the right parietal lobe, with viduospatial dysfunction. Furthermore cerebellar AIs correlated negatively with those of the cerebral hemisphere and lower frontal region in SDAT patients. The results demonstrate that rCBF measurement by {sup 123}I-IMP SPECT is useful to detect lateral asymmetry in reduction of rCBF in SDAT. (author).}
journal = {Kaku Igaku (Japanese Journal of Nuclear Medicine); (Japan)}
volume = {27:12}
journal type = {AC}
place = {Japan}
year = {1990}
month = {Dec}
}