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Autoradiographic studies on nucleic acid synthesis of human gastric cancer cells, 2. Effects of 5-Fluorouracil on nucleic acid synthesis of cancer cells

Journal Article:

Abstract

Changes in nucleic acid synthesis of gastric cancer cells by oral administration of 5-fluorouracil (5-FU) were evaluated autoradiographically. 1) Average /sup 3/H-thymidine labeling index (TLI) in the administered group (31.8%, n = 13) was a significantly high value compared with that of the control group (22.4%, n = 21). This result is considered to show that the pharmacological effects of 5-FU appeared on the cancer cells by the clinical administration of 5-FU. 2) Increase in TLI of the administered group was also found in the advanced stages. However, the degree of its increase seemed to be higher in the early stages. 3) Average /sup 3/H-uridine labeling index (89.9%) was not different from that (92.7%) of control group.
Authors:
Inoue, K [1] 
  1. Kobe Univ. (Japan). School of Medicine
Publication Date:
Mar 01, 1982
Product Type:
Journal Article
Reference Number:
AIX-14-771806; EDB-83-162486
Resource Relation:
Journal Name: Nippon Geka Hokan; (Japan); Journal Volume: 51:2
Subject:
59 BASIC BIOLOGICAL SCIENCES; NUCLEIC ACIDS; BIOSYNTHESIS; TUMOR CELLS; AUTORADIOGRAPHY; CARCINOMAS; FLUOROURACILS; LABELLING; MITOTIC INDEX; PATIENTS; STOMACH; THYMIDINE; TRITIUM COMPOUNDS; URIDINE; ANIMAL CELLS; ANTIMETABOLITES; AZINES; BODY; DIGESTIVE SYSTEM; DISEASES; DRUGS; GASTROINTESTINAL TRACT; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; LABELLED COMPOUNDS; NEOPLASMS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC FLUORINE COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIMIDINES; RIBOSIDES; SYNTHESIS; URACILS; 550201* - Biochemistry- Tracer Techniques
OSTI ID:
5981314
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: NIGHA
Submitting Site:
HEDB
Size:
Pages: 327-335
Announcement Date:

Journal Article:

Citation Formats

Inoue, K. Autoradiographic studies on nucleic acid synthesis of human gastric cancer cells, 2. Effects of 5-Fluorouracil on nucleic acid synthesis of cancer cells. Japan: N. p., 1982. Web.
Inoue, K. Autoradiographic studies on nucleic acid synthesis of human gastric cancer cells, 2. Effects of 5-Fluorouracil on nucleic acid synthesis of cancer cells. Japan.
Inoue, K. 1982. "Autoradiographic studies on nucleic acid synthesis of human gastric cancer cells, 2. Effects of 5-Fluorouracil on nucleic acid synthesis of cancer cells." Japan.
@misc{etde_5981314,
title = {Autoradiographic studies on nucleic acid synthesis of human gastric cancer cells, 2. Effects of 5-Fluorouracil on nucleic acid synthesis of cancer cells}
author = {Inoue, K}
abstractNote = {Changes in nucleic acid synthesis of gastric cancer cells by oral administration of 5-fluorouracil (5-FU) were evaluated autoradiographically. 1) Average /sup 3/H-thymidine labeling index (TLI) in the administered group (31.8%, n = 13) was a significantly high value compared with that of the control group (22.4%, n = 21). This result is considered to show that the pharmacological effects of 5-FU appeared on the cancer cells by the clinical administration of 5-FU. 2) Increase in TLI of the administered group was also found in the advanced stages. However, the degree of its increase seemed to be higher in the early stages. 3) Average /sup 3/H-uridine labeling index (89.9%) was not different from that (92.7%) of control group.}
journal = {Nippon Geka Hokan; (Japan)}
volume = {51:2}
journal type = {AC}
place = {Japan}
year = {1982}
month = {Mar}
}