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Urea utilization in protein deficient rats

Journal Article:

Abstract

Three experiments were performed to investigate the mechanism of urea utilization and the nutritional roles of intestinal flora on the utilization of urea by rats fed with a protein deficient diet. Ammonia content in the small intestine in LPD(low protein diet) group fed with a low protein diet for 2 or 5 weeks was about three of five times higher than that of control group fed with SPD(standard protein diet) after administration of urea (0.2gN/100gB.W.). The /sup 15/N incorporation into plasma protein of LPD group was significantly higher than that of the control group two hours after the administration of /sup 15/N-urea (10 mg/100gB.W.) and higher level of /sup 15/N concentration in plasma protein in LPD group was maintained thereafter. The /sup 15/N incorporation into the amino acids of plasma protein was higher in LPD group than in control group. The /sup 15/N incorporation into the amino acids in portal plasma seemed to be higher in LPD group than in control group one hour after the administration of /sup 15/N-urea (10mg/100gB.W.). However, the /sup 15/N incorporation into each free amino acids was suppressed considerably by the administration of antibiotic mixture. it follows that amino acids may be synthesized from urea  More>>
Authors:
Tanaka, N [1] 
  1. Hyogo College of Medicine, Nishinomiya, Hyogo (Japan)
Publication Date:
Jun 01, 1982
Product Type:
Journal Article
Reference Number:
AIX-14-771796; EDB-83-162522
Resource Relation:
Journal Name: Eiyo To Shokuryo; (Japan); Journal Volume: 35:3
Subject:
59 BASIC BIOLOGICAL SCIENCES; NUTRITIONAL DEFICIENCY; TRACER TECHNIQUES; PROTEINS; METABOLISM; UREA; AMMONIA; ANIMAL FEEDS; BIOSYNTHESIS; LYSINE; NITROGEN 15; RATS; SMALL INTESTINE; TIME DEPENDENCE; AMIDES; AMINO ACIDS; ANIMALS; BODY; CARBONIC ACID DERIVATIVES; CARBOXYLIC ACIDS; DIGESTIVE SYSTEM; FOOD; GASTROINTESTINAL TRACT; HYDRIDES; HYDROGEN COMPOUNDS; INTESTINES; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; MAMMALS; NITROGEN COMPOUNDS; NITROGEN HYDRIDES; NITROGEN ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RODENTS; STABLE ISOTOPES; SYNTHESIS; VERTEBRATES; 550501* - Metabolism- Tracer Techniques
OSTI ID:
5980853
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: EISOA
Submitting Site:
HEDB
Size:
Pages: 175-180
Announcement Date:

Journal Article:

Citation Formats

Tanaka, N. Urea utilization in protein deficient rats. Japan: N. p., 1982. Web.
Tanaka, N. Urea utilization in protein deficient rats. Japan.
Tanaka, N. 1982. "Urea utilization in protein deficient rats." Japan.
@misc{etde_5980853,
title = {Urea utilization in protein deficient rats}
author = {Tanaka, N}
abstractNote = {Three experiments were performed to investigate the mechanism of urea utilization and the nutritional roles of intestinal flora on the utilization of urea by rats fed with a protein deficient diet. Ammonia content in the small intestine in LPD(low protein diet) group fed with a low protein diet for 2 or 5 weeks was about three of five times higher than that of control group fed with SPD(standard protein diet) after administration of urea (0.2gN/100gB.W.). The /sup 15/N incorporation into plasma protein of LPD group was significantly higher than that of the control group two hours after the administration of /sup 15/N-urea (10 mg/100gB.W.) and higher level of /sup 15/N concentration in plasma protein in LPD group was maintained thereafter. The /sup 15/N incorporation into the amino acids of plasma protein was higher in LPD group than in control group. The /sup 15/N incorporation into the amino acids in portal plasma seemed to be higher in LPD group than in control group one hour after the administration of /sup 15/N-urea (10mg/100gB.W.). However, the /sup 15/N incorporation into each free amino acids was suppressed considerably by the administration of antibiotic mixture. it follows that amino acids may be synthesized from urea in the intestine by intestinal-bacterial action and absorbed from portal vein. From these results, it may be concluded that the ammonia nitrogen converted from urea by the action of intestinal-bacterial urease in the intestine is utilized for the synthesis of essential and nonessential amino acids in protein deficient rats and transfered to the liver through portal vein and utilized for protein synthesis.}
journal = {Eiyo To Shokuryo; (Japan)}
volume = {35:3}
journal type = {AC}
place = {Japan}
year = {1982}
month = {Jun}
}