You need JavaScript to view this

Regional cerebral blood flow and brain atrophy in senile dementia of Alzheimer type (SDAT). Comparing with multi-infarct dementia (MID), and aged control

Journal Article:

Abstract

To investigate the relationship between the reduction of cerebal blood flow and brain atrophy in SDAT, these were measured in 13 cases of senile dementia of Alzheimer type, and compared to 15 cases of multi-infarct Dementia, 39 cases of lacunar infarction without dementia (non-demented CVD group) and 69 cases of aged normal control. Brain atrophy was evaluated by two-dimensional method on CT film by digitizer and regional cerebral blood flow (rCBF) was measured by /sup 133/Xe inhalation method. The degree of brain atrophy in SDAT was almost similar of that of MID. But it was more severe than that of non-demented group. MID showed the lowest rCBF among these groups. SDAT showed significantly lower rCBF than that of aged control, but rCBF in SDAT was equal to that of lacunar stroke without dementia. Focal reduction of cerebral blood flow in bilateral fronto-parietal and left occipital regions were observed in SDAT. Verbal intelligence score (Hasegawa's score) correlated with rCBF and brain atrophy index in MID, and a tendency of correlation between rCBF and brain atrophy in MID was also observed. However, there was no correlation among those indices in SDAT. These findings suggest that the loss of brain substance dose not  More>>
Publication Date:
May 01, 1987
Product Type:
Journal Article
Reference Number:
JPN-87-060145; EDB-87-164968
Resource Relation:
Journal Name: Rinsho Shinkeigaku; (Japan); Journal Volume: 27:5
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CEREBRUM; BLOOD FLOW; CAT SCANNING; MENTAL DISORDERS; DIAGNOSIS; XENON 133; DIAGNOSTIC USES; AGED ADULTS; ATROPHY; INHALATION; PATIENTS; VASCULAR DISEASES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; EVEN-ODD NUCLEI; INTAKE; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NERVOUS SYSTEM; NUCLEI; ORGANS; PATHOLOGICAL CHANGES; RADIOISOTOPES; TOMOGRAPHY; USES; XENON ISOTOPES; 550602* - Medicine- External Radiation in Diagnostics- (1980-); 550601 - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5975988
Research Organizations:
Shimane Medical Univ., Izumo, Japan
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: RISHB
Submitting Site:
JPN
Size:
Pages: 545-551
Announcement Date:

Journal Article:

Citation Formats

Okada, K, Kobayashi, S, Yamaguchi, S, Kitani, M, and Tsunematsu, T. Regional cerebral blood flow and brain atrophy in senile dementia of Alzheimer type (SDAT). Comparing with multi-infarct dementia (MID), and aged control. Japan: N. p., 1987. Web.
Okada, K, Kobayashi, S, Yamaguchi, S, Kitani, M, & Tsunematsu, T. Regional cerebral blood flow and brain atrophy in senile dementia of Alzheimer type (SDAT). Comparing with multi-infarct dementia (MID), and aged control. Japan.
Okada, K, Kobayashi, S, Yamaguchi, S, Kitani, M, and Tsunematsu, T. 1987. "Regional cerebral blood flow and brain atrophy in senile dementia of Alzheimer type (SDAT). Comparing with multi-infarct dementia (MID), and aged control." Japan.
@misc{etde_5975988,
title = {Regional cerebral blood flow and brain atrophy in senile dementia of Alzheimer type (SDAT). Comparing with multi-infarct dementia (MID), and aged control}
author = {Okada, K, Kobayashi, S, Yamaguchi, S, Kitani, M, and Tsunematsu, T}
abstractNote = {To investigate the relationship between the reduction of cerebal blood flow and brain atrophy in SDAT, these were measured in 13 cases of senile dementia of Alzheimer type, and compared to 15 cases of multi-infarct Dementia, 39 cases of lacunar infarction without dementia (non-demented CVD group) and 69 cases of aged normal control. Brain atrophy was evaluated by two-dimensional method on CT film by digitizer and regional cerebral blood flow (rCBF) was measured by /sup 133/Xe inhalation method. The degree of brain atrophy in SDAT was almost similar of that of MID. But it was more severe than that of non-demented group. MID showed the lowest rCBF among these groups. SDAT showed significantly lower rCBF than that of aged control, but rCBF in SDAT was equal to that of lacunar stroke without dementia. Focal reduction of cerebral blood flow in bilateral fronto-parietal and left occipital regions were observed in SDAT. Verbal intelligence score (Hasegawa's score) correlated with rCBF and brain atrophy index in MID, and a tendency of correlation between rCBF and brain atrophy in MID was also observed. However, there was no correlation among those indices in SDAT. These findings suggest that the loss of brain substance dose not correspond to the reduction of rCBF in SDAT and simultaneous measurement of rCBF and brain atrophy was useful to differ SDAT from MID.}
journal = {Rinsho Shinkeigaku; (Japan)}
volume = {27:5}
journal type = {AC}
place = {Japan}
year = {1987}
month = {May}
}