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Protein permeation through polymer membranes for hybrid-type artificial pancreas

Journal Article:

Abstract

Hydrogel membranes were prepared by radiation crosslinking of poly (vinyl alcohol) (PVA) in aqueous solutions. Effects of PVA concentration, PVA molecular weight, and radiation dose on the permeation of insulin and immunoglobulin through the membranes were investigated. Glucose permeation was also studied. The crosslinking density affected the size of macromolecular mesh of hydrogel network as well as the water content of membrane responsible for the diffusion of the solutes. The diffusion coefficient linearly increased for all the solutes with the increasing water content in PVA hydrogels, indicating that diffusion occurs primarily through the water hydrating the polymer network. The increase in crosslinking density of hydrogels by changing PVA molecular weight brought about the decrease in mesh size of the hydrogels, which, in turn, had an influence on the diffusion of immunoglobulin, but not of insulin and glucose. (author).
Authors:
Burczak, K; Fujisato, Toshiya; Ikada, Yoshito; [1]  Hatada, Motoyoshi
  1. Kyoto Univ. (Japan)
Publication Date:
May 01, 1991
Product Type:
Journal Article
Reference Number:
JPN-91-012004; EDB-92-028852
Resource Relation:
Journal Name: Proceedings of the Japan Academy, Series B (Physical and Biological Sciences); (Japan); Journal Volume: 67:5
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; 36 MATERIALS SCIENCE; ARTIFICIAL ORGANS; MEMBRANES; CHEMICAL RADIATION EFFECTS; PVA; CROSS-LINKING; DIFFUSION; ELECTRON BEAMS; INSULIN; PERMEABILITY; ALCOHOLS; BEAMS; CHEMICAL REACTIONS; HORMONES; HYDROXY COMPOUNDS; LEPTON BEAMS; ORGANIC COMPOUNDS; ORGANIC POLYMERS; PARTICLE BEAMS; PEPTIDE HORMONES; POLYMERIZATION; POLYMERS; POLYVINYLS; PROTEINS; RADIATION EFFECTS; 400600* - Radiation Chemistry; 360605 - Materials- Radiation Effects
OSTI ID:
5973277
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0386-2208; CODEN: PJABD
Submitting Site:
JPN
Size:
Pages: 83-88
Announcement Date:

Journal Article:

Citation Formats

Burczak, K, Fujisato, Toshiya, Ikada, Yoshito, and Hatada, Motoyoshi. Protein permeation through polymer membranes for hybrid-type artificial pancreas. Japan: N. p., 1991. Web.
Burczak, K, Fujisato, Toshiya, Ikada, Yoshito, & Hatada, Motoyoshi. Protein permeation through polymer membranes for hybrid-type artificial pancreas. Japan.
Burczak, K, Fujisato, Toshiya, Ikada, Yoshito, and Hatada, Motoyoshi. 1991. "Protein permeation through polymer membranes for hybrid-type artificial pancreas." Japan.
@misc{etde_5973277,
title = {Protein permeation through polymer membranes for hybrid-type artificial pancreas}
author = {Burczak, K, Fujisato, Toshiya, Ikada, Yoshito, and Hatada, Motoyoshi}
abstractNote = {Hydrogel membranes were prepared by radiation crosslinking of poly (vinyl alcohol) (PVA) in aqueous solutions. Effects of PVA concentration, PVA molecular weight, and radiation dose on the permeation of insulin and immunoglobulin through the membranes were investigated. Glucose permeation was also studied. The crosslinking density affected the size of macromolecular mesh of hydrogel network as well as the water content of membrane responsible for the diffusion of the solutes. The diffusion coefficient linearly increased for all the solutes with the increasing water content in PVA hydrogels, indicating that diffusion occurs primarily through the water hydrating the polymer network. The increase in crosslinking density of hydrogels by changing PVA molecular weight brought about the decrease in mesh size of the hydrogels, which, in turn, had an influence on the diffusion of immunoglobulin, but not of insulin and glucose. (author).}
journal = {Proceedings of the Japan Academy, Series B (Physical and Biological Sciences); (Japan)}
volume = {67:5}
journal type = {AC}
place = {Japan}
year = {1991}
month = {May}
}